2005
DOI: 10.1002/pssa.200461134
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Porous silicon‐based scaffolds for tissue engineering and other biomedical applications

Abstract: This work describes the formation of porous composite materials based on a combination of bioactive mesoporous silicon and bioerodible polymers such as poly-caprolactone (PCL). The fabrication of a range of composites prepared by both salt leaching and microemulsion techniques are discussed. Particular attention to the influence of Si content in the composite on in vitro calcification assays are assessed. For each system, cytotoxicity and cellular proliferation are explicitly evaluated through fibroblast cell … Show more

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Cited by 141 publications
(87 citation statements)
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“…In Vitro SBF experiments are currently the most convenient and accurate method to test for the possible bioactivity and the bone bonding ability of a material [4,25]. It is not always as accurate as…”
Section: Tem Analysis After Sbfmentioning
confidence: 99%
“…In Vitro SBF experiments are currently the most convenient and accurate method to test for the possible bioactivity and the bone bonding ability of a material [4,25]. It is not always as accurate as…”
Section: Tem Analysis After Sbfmentioning
confidence: 99%
“…Porous silicon (pSi) shows potential as a biocompatible scaffold for applications in orthopaedics (Li et al, 1998;Coffer et al, 2005;Whitehead et al, 2008;Anderson et al, 2010), oncology (Zhang et al, 2005;Mann et al, 2011;Park et al, 2011) and ophthalmology (Low et al, 2006;Cheng et al, 2008;Low et al, 2009;Kashanian et al, 2010). For use in ophthalmic implants designed to deliver drugs or cells to the eye, the advantages of pSi include its large surface area for drug-loading and cell attachment, and good ocular biocompatibility (Low et al, 2009;Kashanian et al, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…Its high surface area has been exploited in drug delivery 16 and biosensor applications 17,18 , where high levels of drug loading were reported. The effectiveness of pSi as a scaffold for bone regeneration also paves the way for tissue engineering applications 19 . pSi can be easily tailored to produce various pore sizes, depths and porosities through judicious choice of the etching conditions.…”
Section: Introductionmentioning
confidence: 99%