The development of nanoscience has allowed to propose new ways of clinical treatment and diagnosis. Specifically, there has been a development of nano-optical devices based on plasmonic effects in metal nanoparticles. Plasmons in nanostructures are highly environmentally sensitive due to localized electric field enhancements, which have been employed, among other devices, in chemical sensors and biosensors. Nanostructured metals have overpassed the sensitivity performance of traditional surface plasmon resonance systems (surface plasmon polaritons travelling on continuous metallic films) (Haes & Van Duyne, 2004; Mauriz, Garcia-Fernandez, & Lechuga, 2016). The sensitivity of the localized surface plasmon approach was emergently exploited with triangular silver nanoparticles in a generic biotin-streptavidin immobilization system (Haes & Van Duyne, 2002). The principle was then transferred to technological substrates (such as optical fibres; Chau, Lin, Cheng, & Lin, 2006) using different metals (mainly gold; Hiep et al., 2007) and nanoscale geometries (such as disks; Hanarp, Kall, & Sutherland, 2003) to solid substrates incorporating more complex immobilization strategies (such as the peptide nucleic acid-DNA binding; Endo, Kerman, Nagatani, Takamura, & Tamiya, 2005). Among the diversity of metallic nanoparticles, gallium nanoparticles (GaNPs) have the advantage that they can be deposited in a fast, simple and cheap way on a wide variety of substrates, that is by applying Joule-effect thermal evaporation. As result of their