Porous silicon nanoparticles for cancer photothermotherapy

Chen, Hong; Lee, Jung-Keun; Zheng, Hongmei; Hong, Soon‐Sun; Lee, Chongmu

doi:10.1186/1556-276x-6-321

Cited by 82 publications

(47 citation statements)

References 45 publications

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“…A solid-state NIR laser (Ocean Optics), which emits light, (785 nm, 500 mW) was guided through an optical fiber the end of which was placed at 2 cm over the liquid/air interface. The temperature was measured using a TES 1326S/1327K infrared thermometer after irradiation pulses (Hong et al 2011;Fu et al 2012).…”

Section: Synthesis and Characterization Of Pani-npsmentioning

confidence: 99%

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

et al. 2015

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Polyaniline nanoparticles (PANI-Nps) have been used in several applications; however, there are few publications related to the use in the photothermal therapy. PANI-Nps have high optical absorbance in the near-infrared region and in this wavelength range, biological systems are relatively transparent. For this reason, these materials can be used to absorb energy and to generate heat that destroys cancer cells selectively. PANI-Nps with average size of ca. 200 nm and neutral zeta potential were synthesized and characterized by DLS, SEM, and zeta potential. The kinetics of incorporation of PANINps into LM2 cell line was monitored using UV-Vis spectrophotometry. The analysis of cell viability after PANI-Nps exposure shows that these nanoparticles are not cytotoxic even at high concentration and show no change in cell morphology and metabolic activity. Furthermore, we found that nanoparticle cell uptake reaches the maximum value c.a. 3 h after incubation. Cells were targeted by Pani-Nps and irradiated, resulting in significant elevation of intracellular ROS and heat production. One of the mechanisms of PANINps-mediated photothermal killing of cancer cells apparently involved oxidative stress resulting in apoptotic cell death.

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Section: Synthesis and Characterization Of Pani-npsmentioning

confidence: 99%

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

et al. 2015

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“…Nanomedicines offer unprecedented advantages in targeted drug delivery into tumours, such as enhanced cellular uptake, controlled release of drugs, and protection of the agents from premature degradation 16 . A range of nanoparticles (NP) have been developed to deliver small molecular drugs to inhibit cancer cell migration [17][18][19] . Interestingly, a few studies reported that NP treatments alone are inhibitory to cancer cell invasion of liver 20 , cervical 21 , and breast 22 origins.…”

mentioning

confidence: 99%

Transferrin-targeted porous silicon nanoparticles reduce glioblastoma cell migration across tight extracellular space

Sheykhzadeh

Luo

Peng

et al. 2020

Sci Rep

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Mortality of glioblastoma multiforme (GBM) has not improved over the last two decades despite medical breakthroughs in the treatment of other types of cancers. Nanoparticles hold tremendous promise to overcome the pharmacokinetic challenges and off-target adverse effects. However, an inhibitory effect of nanoparticles by themselves on metastasis has not been explored. In this study, we developed transferrin-conjugated porous silicon nanoparticles (Tf@pSiNP) and studied their effect on inhibiting GBM migration by means of a microfluidic-based migration chip. This platform, designed to mimic the tight extracellular migration tracts in brain parenchyma, allowed high-content time-resolved imaging of cell migration. Tf@pSiNP were colloidally stable, biocompatible, and their uptake into GBM cells was enhanced by receptor-mediated internalisation. The migration of Tf@ pSiNP-exposed cells across the confined microchannels was suppressed, but unconfined migration was unaffected. The pSiNP-induced destabilisation of focal adhesions at the leading front may partially explain the migration inhibition. More corroborating evidence suggests that pSiNP uptake reduced the plasticity of GBM cells in reducing cell volume, an effect that proved crucial in facilitating migration across the tight confined tracts. We believe that the inhibitory effect of Tf@pSiNP on cell migration, together with the drug-delivery capability of pSiNP, could potentially offer a disruptive strategy to treat GBM.Glioblastoma multiforme (GBM) is the most prevalent and biologically aggressive type of primary brain tumour in adults 1 . Standard treatment is maximal surgical resection of a tumour followed by radiotherapy and temozolomide as an adjuvant chemotherapy 2 . Despite these advanced treatments, the survival rate of GBM patients is still less than 5% over five years, with a median overall survival of merely 15-23 months 3 . The factors that contribute to the high mortality are multifactorial. First and foremost, the diffuse invasion of GBM into brain parenchyma precludes complete surgical resection which leads to high recurrence 4 . Recurring GBM are usually multi-drug resistant, rendering chemotherapy ineffective 5 . On rare occasions, the high invasion and migration potential even leads to extracranial metastases 6 .The mechanisms of GBM invasion and migration are complex and encompasses the regulation of tumour microenvironment and of the molecular arrangement within the migrating GBM cells 7 . To enable migration across the small perivascular space, GBM cells have been shown to reduce their volume by releasing cytoplasmic fluid 8 . The reduction in cell size is particularly instrumental to GBM invasion into healthy brain tissue, since www.nature.com/scientificreports www.nature.com/scientificreports/ recombinant human Fibroblast Growth Factor basic (Gibco, PHG0024), and StemPro Neural Supplement (Gibco, A10508-01). The culture media also contained GlutaMAX (Gibco, 35050-061) and penicillin/streptomycin (Gibco, 15140-122). Cells were only used betwe...

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“…Using a near-infrared light source, pSi has been shown to have heat generation abilities, attributed to high absorbance and large surface-to-volume ratio. [49] Future applications include the use of pSi particles to enhance radiofrequency-induced thermal ablation of cancer cells, expanding the versatility of pSi.…”

Section: Future Perspectivesmentioning

confidence: 99%

Porous silicon advances in drug delivery and immunotherapy

Savage

Liu

Curley

et al. 2013

Current Opinion in Pharmacology

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Biomedical applications of porous silicon include drug delivery, imaging, diagnostics and immunotherapy. This review summarizes new silicon particle fabrication techniques, dynamics of cellular transport, advances in the multistage vector approach to drug delivery, and the use of porous silicon as immune adjuvants. Recent findings support superior therapeutic efficacy of the multistage vector approach over single particle drug delivery systems in mouse models of ovarian and breast cancer. With respect to vaccine development, multivalent presentation of pathogen-associated molecular patterns on the particle surface creates powerful platforms for immunotherapy, with the porous matrix able to carry both antigens and immune modulators.

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Porous silicon nanoparticles for cancer photothermotherapy

Cited by 82 publications

References 45 publications

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

Transferrin-targeted porous silicon nanoparticles reduce glioblastoma cell migration across tight extracellular space

Porous silicon advances in drug delivery and immunotherapy

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