Porous titanium scaffold surfaces modified with silver loaded gelatin microspheres and their antibacterial behavior

Li, Mengting; Wang, Yi; Gao, Lili; Sun, Yuhua; Wang, Jianxin; Qu, Shuxin; Duan, Ke; Weng, Jie; Feng, Bo

doi:10.1016/j.surfcoat.2015.12.006

Cited by 20 publications

(11 citation statements)

References 37 publications

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“…mutans [66], S. aureus [67] and A. acti nomycetemcomitans. [45,46,68] Bacterial counts on ion-implanted surfaces were reduced by 55-80% compared to pure titanium. [53] However, it is unclear how anodic oxidation without ionimplantation influences bacterial adhesion to titanium [68][69][70].…”

Section: Ion-implanted Surfacesmentioning

confidence: 97%

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Review of titanium surface modification techniques and coatings for antibacterial applications

et al. 2019

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Implanted biomaterials play a key role in the current success of orthopedic and dental procedures. Pure titanium and its alloys are the most commonly used materials for permanent implants in contact with bone. However, implant-related infections remain among the leading reasons for failure. The most critical pathogenic event in the development of infection on biomaterials is biofilm formation, which starts immediately after bacterial adhesion. In the last decade, numerous studies reported the ability of titanium surface modifications and coatings to minimize bacterial adhesion, inhibit biofilm formation and provide effective bacterial killing to protect implanted biomaterials. In the present review, the different strategies to prevent infection onto titanium surfaces are reported: surface modification and coatings by antibiotics, antimicrobial peptides, inorganic antibacterial metal elements and antibacterial

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Section: Ion-implanted Surfacesmentioning

confidence: 97%

“…Li et al [45] elaborated silver loaded gelatin microspheres and incorporated them into porous titanium to produce antibacterial implants. The silver loaded samples were able to inhibit bacterial growth (S. aureus and E. coli).…”

Section: Silvermentioning

confidence: 99%

Review of titanium surface modification techniques and coatings for antibacterial applications

et al. 2019

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“…In order to replace antibiotics, antibacterial strategies such as the addition of silver to titanium, the exposure of TiO 2 surfaces to UV light [9,10], the addition to antibacterial nanoparticles [11], novel surface design [12], and even thin film coatings [13] have all been investigated. With respect to bulk alloying and oxides, Ag has been found to be undesirable as a result of its efficacy being limited to environments of higher pH and elevated temperature levels [14], while, despite TiO 2 forming naturally on all titanium surfaces when in contact with oxygen, the antibacterial effect can only be achieved after these surfaces are exposed to UV light [15].…”

Section: Introductionmentioning

confidence: 99%

Effect of Copper Ion Concentration on Bacteria and Cells

2019

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In the oral cavity, dental implants—most often made of commercially pure titanium—come in contact with bacteria, and antibacterial management has been researched extensively to improve patient care. With antibiotic resistance becoming increasingly prevalent, this has resulted in copper being investigated as an antibacterial element in alloys. In this study, the objective was to investigate the copper ion concentrations at which cyto-toxicity is avoided while bacterial inhibition is ensured, by comparing Cu ion effects on selected eukaryotes and prokaryotes. To determine relevant copper ion concentrations, ion release rates from copper and a 10 wt. % Cu Ti-alloy were investigated. Survival studies were performed on MC3T3 cells and Staphylococcus epidermidis bacteria, after exposure to Cu ions concentrations ranging from 9 × 10−3 to 9 × 10−12 g/mL. Cell survival increased from <10% to >90% after 24 h of exposure, by reducing Cu concentrations from 9 × 10−5 to 9 × 10−6 g/mL. Survival of bacteria also increased in the same range of Cu concentrations. The maximum bacteria growth was found at 9 × 10−7 g/mL, probably due to stress response. In conclusion, the minimum inhibitory concentrations of Cu ions for these prokaryotes and eukaryotes were found in the range from 9 × 10−5 to 9 × 10−6 g/mL. Interestingly, the Cu ion concentration correlating to the release rate of the 10 wt. % Cu alloy (9 × 10−8 g/mL) did not kill the bacteria, although this alloy has previously been found to be antibacterial. Further studies should investigate in depth the bacteria-killing mechanism of copper.

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“…The AgNPs at a concentration of approximately 0.02 mg/cm 2 hindered bacterial growth. Finally, in [244], silver loaded gelatin microspheres were incorporated into porous titanium. The high antibacterial ability against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), was demonstrated.…”

Section: Antibacterial Effectsmentioning

confidence: 99%

Structural and Material Determinants Influencing the Behavior of Porous Ti and Its Alloys Made by Additive Manufacturing Techniques for Biomedical Applications

Dziaduszewska

Zieliński

2021

Materials

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One of the biggest challenges in tissue engineering is the manufacturing of porous structures that are customized in size and shape and that mimic natural bone structure. Additive manufacturing is known as a sufficient method to produce 3D porous structures used as bone substitutes in large segmental bone defects. The literature indicates that the mechanical and biological properties of scaffolds highly depend on geometrical features of structure (pore size, pore shape, porosity), surface morphology, and chemistry. The objective of this review is to present the latest advances and trends in the development of titanium scaffolds concerning the relationships between applied materials, manufacturing methods, and interior architecture determined by porosity, pore shape, and size, and the mechanical, biological, chemical, and physical properties. Such a review is assumed to show the real achievements and, on the other side, shortages in so far research.

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Porous titanium scaffold surfaces modified with silver loaded gelatin microspheres and their antibacterial behavior

Cited by 20 publications

References 37 publications

Review of titanium surface modification techniques and coatings for antibacterial applications

Review of titanium surface modification techniques and coatings for antibacterial applications

Effect of Copper Ion Concentration on Bacteria and Cells

Structural and Material Determinants Influencing the Behavior of Porous Ti and Its Alloys Made by Additive Manufacturing Techniques for Biomedical Applications

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