Porównanie skuteczności elastografii w diagnostyce zmian pęcherzykowych tarczycy i ognisk z jednoznacznym wynikiem BAC

Wojtaszek-Nowicka, Martyna; Słowińska-Klencka, Dorota; Sporny, Stanisław; Popowicz, Bożena; Kuzdak, Krzysztof; Pomorski, Lech; Kaczka, Krzysztof; Sopiński, Jan; Klencki, Mariusz

doi:10.5603/ep.a2017.0050

Cited by 7 publications

(2 citation statements)

References 47 publications

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“…SoR: G1; QoE: + / PolCon 62/62 5.6. Elastography may be helpful in the selection of a lesion for FNAB; however, it is not obligatory [10][11][12][13][14] SoR: G1; QoE: PolCon 62/62 6. Indications for FNAB after diagnosis of thyroid lesion by other imaging modalities.…”

Section: Quality Of Evidences (Qoe)mentioning

confidence: 99%

Rekomendacje Polskich Towarzystw Naukowych „Diagnostyka i leczenie raka tarczycy”. Aktualizacja na rok 2018

Jarząb¹,

Dedecjus²,

Słowińska-Klencka³

et al. 2018

Endokrynologia Polska

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Section: Quality Of Evidences (Qoe)mentioning

confidence: 99%

Rekomendacje Polskich Towarzystw Naukowych „Diagnostyka i leczenie raka tarczycy”. Aktualizacja na rok 2018

Jarząb¹,

Dedecjus²,

Słowińska-Klencka³

et al. 2018

Endokrynologia Polska

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“…Although elastography can be performed in various ways and by means of various techniques [ 25 ], there is no consensus as to which approach is most able to rule out malignancy. In many cases, indeed, the semi-quantitative and operator-dependent real-time elastosonography (ELX 2/1) technique has shown a better performance than the more recent shear-wave technique [ 24 , 26 , 35 ]. Our data confirm this notion, since the ELX 2/1 score was the only parameter that correlated significantly with histological outcomes.…”

Section: Discussionmentioning

confidence: 99%

Role of Strain Elastography and Shear-Wave Elastography in a Multiparametric Clinical Approach to Indeterminate Cytology Thyroid Nodules

et al. 2018

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BackgroundIn thyroid nodules with indeterminate cytology, further clinical assessment aimed at ruling out malignancy is often mandatory. Ancillary imaging techniques and genetic mutation analysis can improve the risk stratification of such lesions, thereby facilitating the clinician’s decision to undertaken surgery or simple follow-up. The aim of this study was to evaluate the diagnostic performance of shear-wave elastography (SW), strain elastography (ELX 2/1), conventional ultrasound (US), contrast-enhanced ultrasound (CEUS), and BRAF V600E mutation analysis in the aforementioned lesions.Material/MethodsWe enrolled 81 patients, each with 1 indeterminate-cytology thyroid nodule. Thyroid function, thyroperoxidase antibodies and calcitonin were known in each case. SW, ELX 2/1, US, CEUS, and BRAF mutation analysis were subsequently performed, followed by a second FNAB. If the lesion was not downgraded to benign, surgery was recommended and histological reports collected.ResultsThere were 28 nodules (34%) that proved benign on the second FNAB; 38 nodules (47%) underwent surgery (17 benign, 21 malignant), and 15 nodules (19%) refused surgery. The only techniques related to histological outcome were US (AUC=0,766), ELX 2/1 (AUC=0.701), and BRAF analysis (AUC=0.762). ELX 2/1 and SW reports were not correlated with each other (P=0.45). A scoring system taking into account all the variables considered performed better than the single variables alone (AUC=0.831).ConclusionsIn indeterminate-cytology thyroid lesions, repeating FNAB can avoid unnecessary surgery. ELX 2/1 seems to perform better than SW in distinguishing malignancy; these techniques could, however, be complementary in describing such lesions. A multiparametric approach appears the most accurate in predicting nodule histology.

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TIRADS, SRE and SWE in INDETERMINATE thyroid nodule characterization: Which has better diagnostic performance?

et al. 2021

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Purpose To assess Strain Ratio (SRE) and Shear Wave Elastography (SWE) accuracy alone and with TIRADS classification, for the risk stratification of indeterminate thyroid nodules. Materials and methods 128 Patients with 128 indeterminate nodules candidates for thyroidectomy underwent preoperative staging neck ultrasound and were classified according to K-TIRADS score. After TIRADS evaluation, semi-quantitative (SRE) and quantitative (SWE expressed in kPa) elastosonography were performed and relative diagnostic performances, alone and in combination, were compared through ROC curves analysis. In order to maximize the SRE and SWE sensitivity and specificity, their cut-off values were calculated using the Liu test. Bonferroni test was used to evaluate statistically significant differences with a p value < 0.05. Results Sensitivity, specificity, PPV and NPV were, respectively, 71.4%, 82.4%, 62.5%, 87.5% for K-TIRADS baseline US, 85.7%, 94.1%, 85.7%, 94.1% for SRE and 57.1%, 79.4%, 53.3%, 81.8% for SWE (kPa expressed). SRE evaluation showed the best diagnostic accuracy compared to the SWE (kPa expressed) (p < 0.05) and to the K-TIRADS (p > 0.05). The association of SRE with conventional ultrasound with K-TIRADS score increased sensitivity (92.9% vs 71.4%) but decreased the specificity than conventional US alone (76.5% vs 82.4%). Conclusion Strain Elastosonography can be associated with K-TIRADS US examination in the thyroid nodule characterization with indeterminate cytology; in fact, adding the SRE to K-TIRADS assessment significantly increases its sensitivity and negative predictive value. However, further multicenter studies on larger population are warranted.

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Porównanie skuteczności elastografii w diagnostyce zmian pęcherzykowych tarczycy i ognisk z jednoznacznym wynikiem BAC

Cited by 7 publications

References 47 publications

Rekomendacje Polskich Towarzystw Naukowych „Diagnostyka i leczenie raka tarczycy”. Aktualizacja na rok 2018

Rekomendacje Polskich Towarzystw Naukowych „Diagnostyka i leczenie raka tarczycy”. Aktualizacja na rok 2018

Role of Strain Elastography and Shear-Wave Elastography in a Multiparametric Clinical Approach to Indeterminate Cytology Thyroid Nodules

TIRADS, SRE and SWE in INDETERMINATE thyroid nodule characterization: Which has better diagnostic performance?

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