Porphyran capped gold nanoparticles as a novel carrier for delivery of anticancer drug: In vitro cytotoxicity study

Venkatpurwar, Vinod; Shiras, Anjali; Pokharkar, Varsha

doi:10.1016/j.ijpharm.2011.02.054

Cited by 109 publications

(46 citation statements)

References 41 publications

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“…All the characteristic peaks of GCV were also found in GCV loaded AuNPs-GSH. Venkatpurwar et al [16] also reported possibility of hydrogen bonding in addition to electrostatic interaction between protonated amine group and anionic gold nanoparticles. GCV-loaded AuNPs-GSH were also kept at room temperature in closed glass vial to study stability of nanoparticles for 24 h. No colour change was observed visually for GCVloaded AuNPs-GSH.…”

Section: Resultsmentioning

confidence: 99%

“…Also electrostatic or hydrogen bond attachment of drug with AuNPs may be a better strategy than covalent linkage [15] . Venkatpurwar et al [16] reported attachment of doxorubicin with porphyran reduced AuNPs by electrostatic interaction. Mirza et al [17] also reported direct conjugation of doxorubicin by electrostatic binding of protonated amine group of doxorubicin with negatively charged citrate-reduced AuNPs.…”

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confidence: 99%

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Preparation and Characterization of Ganciclovir Loaded Glutathione Modified Gold Nanoparticles

Kiroula¹,

Negi²

2016

pharmaceutical-sciences

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Kiroula, et al.: Glutathione-modified Gold Nanoparticles of GanciclovirThis article reports that ganciclovir-loaded gold nanoparticles were developed via glutathione surface modification. Citrate-reduced gold nanoparticles were prepared first from chloroauric acid. Further the surface of gold nanoparticles was modified with glutathione. Then ganciclovir was loaded onto the glutathione-modified gold nanoparticles through the reaction between carboxyl group of glutathione and amino group of ganciclovir. Gold nanoparticles were characterized by photon correlation spectroscopy, transmission electron microscopy and infrared spectroscopy. Drug loading of 87.27±2.52% was observed for ganciclovir-loaded gold nanoparticles. The particle size distribution of gold nanoparticles ranged from 26.3 to 31 nm. Thus ganciclovir-loaded gold nanoparticles were successfully prepared, which might further improve the oral bioavailability of ganciclovir.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

Preparation and Characterization of Ganciclovir Loaded Glutathione Modified Gold Nanoparticles

Kiroula¹,

Negi²

2016

pharmaceutical-sciences

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“…Venkatpurwar et al prepared AuNPs capped with porphyran, and these particles exhibited enhanced cytotoxicity in human glioma cells (LN-229), as compared with native porphyran. 20 They also reported on AuNPs utilized as carriers for the delivery of the anticancer drug doxorubicin hydrochloride, and the doxorubicin-loaded AuNPs demonstrated higher cytotoxicity towards LN-229 cells, as compared with an equal dose of native doxorubicin solution. 20 Functionalized AuNPs capped with 3-mercaptopropionic acid have also been fabricated, and the effects of these AuNPs on two leukemia cell lines, adriamycin-sensitive K562 cells and adriamycin-resistant K562/A02 cells, have been assayed.…”

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confidence: 99%

“…20 They also reported on AuNPs utilized as carriers for the delivery of the anticancer drug doxorubicin hydrochloride, and the doxorubicin-loaded AuNPs demonstrated higher cytotoxicity towards LN-229 cells, as compared with an equal dose of native doxorubicin solution. 20 Functionalized AuNPs capped with 3-mercaptopropionic acid have also been fabricated, and the effects of these AuNPs on two leukemia cell lines, adriamycin-sensitive K562 cells and adriamycin-resistant K562/A02 cells, have been assayed. 21 Guo et al demonstrated that these functionalized AuNPs could increase the hydrophobicity of both cell suspensions, greatly decrease the peak potential of both cell lines, and facilitate the cellular uptake of the anticancer drug As 2 O 3 into K562 leukemia cells.…”

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confidence: 99%

The preparation and characterization of gold-conjugated polyphenol nanoparticles as a novel delivery system

Hsieh

Lu²,

Chen³

et al. 2012

IJN

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Nanogold particles are commonly used in nanomedicine. We generated physical nanogold (pNG) conjugated with different ratios of epigallocatechin-3-gallate (EGCG) and evaluated its physicochemical properties, antioxidant activity, and cytotoxicity in vitro as well as anticancer activity in vivo. Results showed that the EGCG-pNG conjugates were successfully prepared at ratios between 23:1 and 23:5, with the percentage of EGCG content increasing with the EGCG:pNG ratio from 23:1 (2.0% ± 0.02%) to 23:5 (28% ± 0.3%). EGCG-pNG particles at ratios of 23:1 and 23:5 demonstrated significantly decreased size from 500 to 20 nm and decreasing zeta potentials of 21 mV to -22 mV, respectively. At a ratio of 23:2.5, the EGCGpNG particles (27% EGCG, 50 nm in size, zeta potential of -8 mV) showed longer EGCG activity half-life (110 days vs 5 hours), controlled release (2 hours vs 30 minutes), and higher antioxidant activity (four times), as well as inhibition of tumor cell growth, than controls. The present study indicated that EGCG-pNG possesses promising therapeutic potential, based on its strong free-radical scavenging and anticancer activities.

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“…In one such study, a sulfated polysaccharide, porphyran derived from marine red algae was utilized for synthesis of doxorubicin conjugated AuNPs. The system itself demonstrated higher cytotoxicity on human glioma cells than pure doxorubicin at a similar dose of 1 μg/ml due to the targeted action of porphyran [85].…”

Section: Drug Deliverymentioning

confidence: 99%

Green Synthesis of Therapeutic Nanoparticles: an Expanding Horizon

Kumar¹,

Lather²,

Pandita³

2015

Nanomedicine (Lond.)

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Nanotechnology continues to achieve tremendous awards in therapeutics, but the economical and ecofriendly production of nanoparticles (NPs) is still in infancy, simply due to the nanotoxicity, unprecedented health hazards and scale up issues. Green nanotechnology was introduced in the quest to mitigate such risks by utilizing natural resources as biological tool for NP synthesis. The key advantages offered by green approach include lower capital and operating expenses, reduced environmental impacts, superior biocompatibility and higher stability. In this review, we shed light on the biosynthesis of therapeutic NPs along with their numerous biomedical applications. Toxicity aspects of NPs and the impact of green approach on it, is also discussed briefly.

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Porphyran capped gold nanoparticles as a novel carrier for delivery of anticancer drug: In vitro cytotoxicity study

Cited by 109 publications

References 41 publications

Preparation and Characterization of Ganciclovir Loaded Glutathione Modified Gold Nanoparticles

Preparation and Characterization of Ganciclovir Loaded Glutathione Modified Gold Nanoparticles

The preparation and characterization of gold-conjugated polyphenol nanoparticles as a novel delivery system

Green Synthesis of Therapeutic Nanoparticles: an Expanding Horizon

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