Porphyran-capped gold nanoparticles modified carbon paste electrode: a simple and efficient electrochemical sensor for the sensitive determination of 5-fluorouracil

Lima, Dhésmon; Calaça, Giselle Nathaly; Viana, Adriano Gonçalves; Pessôa, Christiana Andrade

doi:10.1016/j.apsusc.2017.08.228

Cited by 59 publications

(20 citation statements)

References 52 publications

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“…This is due to the increased surface area and fast response rate owing to the enhanced electron-transfer kinetics and reduced resistance [15][16][17]. One class of nanomaterials is metallic nanoparticles, which have attracted great attention due to their variety of applications in fields of biomedical optical and electrical sensing, resulting in the fabrication of many sensors for the detection of various analytes [18,19]. An example of the metallic nanoparticles is silver nanoparticles (AgNp).…”

Section: Introductionmentioning

confidence: 99%

Influence of Nitrogen-Doped Carbon Dot and Silver Nanoparticle Modified Carbon Paste Electrodes on the Potentiometric Determination of Tobramycin Sulfate: A Comparative Study

et al. 2021

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Two inexpensive and simple methods for synthesis of carbon nanodots were applied and compared to each other, namely a hydrothermal and microwave-assisted method. The synthesized carbon nanodots were characterized using transmission electron microscopy (TEM), ultraviolet-visible (UV-Vis), photoluminescence (PL), Fourier transform-infrared spectroscopy (FTIR), and X-ray diffraction (XRD). The synthesized microwave carbon nanodots had smaller particle size and were thus chosen for better electrochemical performance. Therefore, they were used for our modification process. The proposed electrodes performance characteristics were evaluated according to the IUPAC guidelines, showing linear response in the concentration range 10−6–10−2, 10−7–10−2, and 10−8–10−2 M of tobramycin with a Nernstian slope of 52.60, 58.34, and 57.32 mV/decade for the bare, silver nanoparticle and carbon nanodots modified carbon paste electrodes, respectively. This developed potentiometric method was used for quantification of tobramycin in its co-formulated dosage form and spiked human plasma with good recovery percentages and without interference of the co-formulated drug loteprednol etabonate and excipients.

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Section: Introductionmentioning

confidence: 99%

Influence of Nitrogen-Doped Carbon Dot and Silver Nanoparticle Modified Carbon Paste Electrodes on the Potentiometric Determination of Tobramycin Sulfate: A Comparative Study

et al. 2021

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“…The linear detection range is 10 –7 –10 –3 M with a correlation coefficient of R 2 = 0.961, and the calculated LOD of the EB-TFP:Eu(BTA) 4 probe for 5FU in aqueous solution is 5.13 × 10 –8 M. Compared with other works, EB-TFP:Eu(BTA) 4 shows comparable efficacy for detecting 5FU in aqueous solution (Table S2). − …”

Section: Results and Discussionmentioning

confidence: 99%

Fabricating Nanosheets and Ratiometric Detection of 5-Fluorouracil by Covalent Organic Framework Hybrid Material

Wang

Zhao

et al. 2021

Anal. Chem.

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Covalent organic framework (COF) nanosheets (NSs) are a new member in the family of two-dimensional (2D) nanomaterials that received increasing attention. The ability to prepare COF NSs with rapid acquisition is of great importance to explore their distinctive properties and potential applications. Herein, we elaborate design a new COF hybrid material EB-TFP:Eu(BTA)4 as a sensing platform. In the process of ratiometric fluorescence detection of 5-fluorouracil (5FU), an anticancer drug, we realize the preparation of COF NSs. Interaction occurs between 5FU and COF hybrid material, where the interlayer π–π stacking of COF was weakened, benefiting the exfoliation of bulk COF to acquire 2D COF NSs. This strategy provides not only a sensitive and selective 5FU sensor but also a significant inspiration for engineering 2D COF NSs.

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“…28,29 Carbon paste electrodes modified with porphyrancapped Au-NPs (CPE/Au-NPs-PFR) were used by Lima et al to detect 5-FU as an anticancer drug. 30 They synthesized Au-NPs by using PFR that acts as a stabilizing and reducing agent. At 70°C, 128.7 nm was the smallest particle size that was obtained.…”

Section: -Fu Release From Au-npsmentioning

confidence: 99%

“…Numerous research studies using PEG, poly(amidoamine) dendrimers, PLGA, poly-l-lysine (PLL), and poly(d,llactic-co-glycolic acid) and their block copolymers have been reported to be in development to design a biodegradable hydrophilic folate-NP conjugate for cancer targeting systems. [26][27][28][29][30] These targeting systems show good efficiency in their internalization and biocompatibility; however, the large size of these macromolecule-based systems does not facilitate intravenous delivery. 31 In order to effectively pass a NPs-folate-conjugated system from the blood stream and reach the target cell of interest, their size and colloidal stability in the physiological environment should be considered as important factors.…”

Section: Fa Release From Au-npsmentioning

confidence: 99%

<p>A review of small molecules and drug delivery applications using gold and iron nanoparticles</p>

Jahangirian¹,

Kalantari²,

Izadiyan³

et al. 2019

IJN

177

106

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Conventional cancer treatment techniques show several limitations including low or no specificity and consequently a low efficacy in discriminating between cancer cells and healthy cells. Recent nanotechnology developments have introduced smart and novel therapeutic nanomaterials that take advantage of various targeting approaches. The use of nanotechnology in medicine and, more specifically, drug delivery is set to spread even more rapidly than it has over the past two decades. Currently, many nanoparticles (NPs) are under investigation for drug delivery including those for cancer therapy. Targeted nanomaterials bind selectively to cancer cells and greatly affect them with only a minor effect on healthy cells. Gold nanoparticles (Au-NPs), specifically, have been identified as significant candidates for new cancer therapeutic modalities because of their biocompatibility, easy functionalization and fabrication, optical tunable characteristics, and chemophysical stability. In the last decade, there has been significant research on Au-NPs and their biomedical applications. Functionalized Au-NPs represent highly attractive and promising candidates for drug delivery, owing to their unique dimensions, tunable surface functionalities, and controllable drug release. Further, iron oxide NPs due to their "superparamagnetic" properties have been studied and have demonstrated successful employment in numerous applications. In targeted drug delivery systems, drug-loaded iron oxide NPs can accumulate at the tumor site with the aid of an external magnetic field. This can lead to incremental effectiveness in drug release to the tumor site and vanquish cancer cells without harming healthy cells. In order for the application of iron oxide NPs in the human body to be realized, they should be biodegradable and biocompatible to minimize toxicity. This review illustrates recent advances in the field drug and small molecule delivery such as fluorouracil, folic acid, doxorubicin, paclitaxel, and daunorubicin, specifically when using gold and iron oxide NPs as carriers of anticancer therapeutic agents.

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Porphyran-capped gold nanoparticles modified carbon paste electrode: a simple and efficient electrochemical sensor for the sensitive determination of 5-fluorouracil

Cited by 59 publications

References 52 publications

Influence of Nitrogen-Doped Carbon Dot and Silver Nanoparticle Modified Carbon Paste Electrodes on the Potentiometric Determination of Tobramycin Sulfate: A Comparative Study

Influence of Nitrogen-Doped Carbon Dot and Silver Nanoparticle Modified Carbon Paste Electrodes on the Potentiometric Determination of Tobramycin Sulfate: A Comparative Study

Fabricating Nanosheets and Ratiometric Detection of 5-Fluorouracil by Covalent Organic Framework Hybrid Material

<p>A review of small molecules and drug delivery applications using gold and iron nanoparticles</p>

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