Porphyria cutanea tarda and hepatocellular carcinoma

Topi, G. C.; Gandolfo, L. D'Alessandro; Griso, D.; Morini, Sergio

doi:10.1016/0020-711x(80)90179-2

Cited by 15 publications

(6 citation statements)

References 3 publications

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“…An underlying liver disease is usually associated with PCT (3,5,6), but its association with primary liver cancer has been only rarely reported (7)(8)(9)(10)(11)(12)(13)(14)(15)(16), and the reports have been contradictory. While Kordac (17) found a very high frequency (47.2 %) in 36 necropsy studies, Topi et al (18) did not find any case of this tumor among the 96 PCT patients studied.…”

mentioning

confidence: 83%

Association of Porphyria Cutanea Tarda and Primary Liver Cancer: Report of Ten Cases

Solis

Betancor

Campos

et al. 1982

The Journal of Dermatology

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Studies of the association between porphyria cutanea tarda (PCT) and primary liver cancer have produced conflicting reports. The incidence of this liver tumor was studied in 138 PCT patients (7.2%) and in 358 non‐porphyric cirrhotic patients (5.6%), and no statistically significant differences were found between them (p>0.5). Nevertheless the incidence of such association was significantly higher (chi square=10.91, p<0.001) in the PCT group (24.3%) than in the non‐porphyric cirrhotic group (6.7%) when only males with underlying liver cirrhosis were considered. These results suggest that the high incidence of liver tumor in PCT is not merely related to hepatic cirrhosis. The cause of such as association remains unclear. Primary liver cancer may reveal a prior deficiency in uroporphyrinogen‐decarboxylase, but the possibility that the enzyme abnormalities were caused by the liver carcinoma also exists.

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mentioning

confidence: 83%

Association of Porphyria Cutanea Tarda and Primary Liver Cancer: Report of Ten Cases

Solis

Betancor

Campos

et al. 1982

The Journal of Dermatology

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“…We cannot exclude the selection bias of seeing patients referred from Dermatology Services, rather than seeing all the patients evaluated in that service, which may, if anything, increase the measured incidence of HCC. The relatively low incidence of HCC in PCT has been confirmed by others [11][12][13]. In fact, the incidence of this type of tumour in patients with PCT has been 0% in one study, even after more than 500 patient-years of follow-up [11].…”

Section: Discussionmentioning

confidence: 57%

“…The relatively low incidence of HCC in PCT has been confirmed by others [11][12][13]. In fact, the incidence of this type of tumour in patients with PCT has been 0% in one study, even after more than 500 patient-years of follow-up [11]. Nevertheless, some authors have tried to identify the variables associated with the risk of HCC in patients with PCT.…”

Section: Discussionmentioning

confidence: 72%

“…Liver disease is seen in almost all cases of PCT, the cause of which is not completely known [1,2]. Several reports have suggested that patients with PCT are at high risk of developing hepatocellular carcinoma (HCC) [3][4][5][6][7][8][9][10]; however, this has not been confirmed by other workers [11][12][13]. Nevertheless, it has not been established whether the disorder of porphyrin metabolism per se increases the risk of HCC, or tumour development may merely be due to the underlying cirrhosis itself; or, perhaps, other extrinsic factors such as alcohol consumption or hepatitis viruses are the main factors responsible for HCC [3].…”

Section: Introductionmentioning

confidence: 99%

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Hepatocellular carcinoma risk in patients with porphyria cutanea tarda

Gisbert¹,

Garcı́a-Buey²,

Alonso

et al. 2004

European Journal of Gastroenterology & Hepatology

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The risk of developing HCC in patients with PCT in our area is relatively low (a yearly incidence of less than 1% per patient-year of follow-up), and perhaps attributable, at least in part, to concomitant HCV infection. Patients presenting with PCT should undergo both HCV infection determination and liver biopsy, and those with concomitant HCV infection or advanced fibrosis/cirrhosis should probably be included in a standard surveillance programme in order to achieve early diagnosis of HCC.

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“…On the basis of the foregoing, Topic t al. [14] screened 96 patients with PCT for hepatocellular car cinoma. Alpha-fetoprotein blood levels and liver iso tope scans were performed in all patients but no cases of hepatoma were identified.…”

Section: Discussionmentioning

confidence: 99%