Porphyrin derivatives as inhibitors for acetylcholinesterase from Drosophila melanogaster

Hai, Abdul; Kizilbash, Nadeem; Zaidi, SyedaHuma H; Alruwaili, Jamal

doi:10.6026/97320630009645

Cited by 7 publications

(1 citation statement)

References 18 publications

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“…We have previously evaluated Porphyrins in the context of photodynamic therapy (PDT) since they strongly absorb visible light in the blue region 14. In addition, we have also shown that these compounds serve as inhibitors for Acetylcholinesterase enzyme in erythrocytes and nerve tissue 15,16. This study was conducted to investigate the three Porphyrin derivatives: Tetraphenylporphinesulfonate (TPPS), 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) Chloride (FeTPPS) and 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) nitrosyl Chloride (FeNOTPPS), as candidate compounds for increasing the Na + , K + -ATPase activity in erythrocytes.…”

Section: Introductionmentioning

confidence: 99%

Increase in activity of Na+, K+-ATPase by Porphyrin compounds as treatment for Dysnatremias caused by Diabetes Mellitus

Hai

Kizilbash

2016

Pak J Med Sci

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Objective:The aim of this study was to test the action of Porphyrin compounds, Tetraphenylporphine sulfonate (TPPS), 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) Chloride (FeTPPS) and 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) nitrosyl Chloride (FeNOTPPS), on Na+, K+ -ATPase of cell membrane of erythrocytes.Methods:Enzymatic assays, measuring the amount of inorganic phosphate produced, were used to estimate the activity of Na+, K+-ATPase.Results:The results show that Porphyrin compounds exert an insulin-like effect on Na+, K+-ATPase. They act by increasing the activity of the membrane-bound enzyme.Conclusion:All the three Porphyrin compounds increased the activity of erythrocyte Na+, K+-ATPase. The exact mechanism of action of these compounds is not clear.

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Section: Introductionmentioning

confidence: 99%

Increase in activity of Na+, K+-ATPase by Porphyrin compounds as treatment for Dysnatremias caused by Diabetes Mellitus

Hai

Kizilbash

2016

Pak J Med Sci

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Pharmacogenomics of Alzheimer’s Disease: Novel Therapeutic Strategies for Drug Development

Cacabelos

Torrellas

et al. 2014

Methods in Molecular Biology

165

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Alzheimer's disease (AD) is a major problem of health and disability, with a relevant economic impact on our society. Despite important advances in pathogenesis, diagnosis, and treatment, its primary causes still remain elusive, accurate biomarkers are not well characterized, and the available pharmacological treatments are not cost-effective. As a complex disorder, AD is a polygenic and multifactorial clinical entity in which hundreds of defective genes distributed across the human genome may contribute to its pathogenesis. Diverse environmental factors, cerebrovascular dysfunction, and epigenetic phenomena, together with structural and functional genomic dysfunctions, lead to amyloid deposition, neurofibrillary tangle formation, and premature neuronal death, the major neuropathological hallmarks of AD. Future perspectives for the global management of AD predict that genomics and proteomics may help in the search for reliable biomarkers. In practical terms, the therapeutic response to conventional drugs (cholinesterase inhibitors, multifactorial strategies) is genotype-specific. Genomic factors potentially involved in AD pharmacogenomics include at least five categories of gene clusters: (1) genes associated with disease pathogenesis; (2) genes associated with the mechanism of action of drugs; (3) genes associated with drug metabolism (phase I and II reactions); (4) genes associated with drug transporters; and (5) pleiotropic genes involved in multifaceted cascades and metabolic reactions. The implementation of pharmacogenomic strategies will contribute to optimize drug development and therapeutics in AD and related disorders.

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Curcumin-supplemented diets improve antioxidant enzymes and alter acetylcholinesterase genes expression level in Drosophila melanogaster model

et al. 2017

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Curcumin, a bioactive polyphenolic compound in turmeric (Curcuma longa) rhizomes has been shown to exert anti-aging properties with limited scientific basis. Hence, this study sought to examine the antioxidant and anti-cholinesterase activities of curcumin-supplemented diets as well as their molecular effect on superoxide dismutase (SOD) and acetylcholinesterase (AChE) genes expression level associated with lifespan extension in Drosophila melanogaster model. In this experiment, D. melanogaster (both genders) of 1 to 3 days old were fed diets either containing no curcumin (control) or supplemented with curcumin at 0.2 and 1.0 mg/g of diet for 7 days. Subsequently, the survival and locomotor activities were determined. In addition, we evaluated RT-PCR expressions of SOD and AChE mRNA genes. Furthermore, catalase, SOD and AChE activities were determined. Curcumin-supplemented diet improves survival ability but did not affect locomotor activity when compared with the control. In addition, there was a significant increase in SOD and catalase with a concomitant decrease of AChE activities when compared with the control. Furthermore, curcumin-supplemented diets suppress AChE mRNA expression but no alteration on SOD gene expression level was observed when compared with control. In conclusion, our present results suggest that a down-regulation of AChE gene expression with a concomitant decrease of AChE activity as well as improving antioxidant status could be some possible mechanism in which curcumin exert anti-aging potential and increases lifespan of D. melanogaster.

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Porphyrin derivatives as inhibitors for acetylcholinesterase from Drosophila melanogaster

Cited by 7 publications

References 18 publications

Increase in activity of Na+, K+-ATPase by Porphyrin compounds as treatment for Dysnatremias caused by Diabetes Mellitus

Increase in activity of Na+, K+-ATPase by Porphyrin compounds as treatment for Dysnatremias caused by Diabetes Mellitus

Pharmacogenomics of Alzheimer’s Disease: Novel Therapeutic Strategies for Drug Development

Curcumin-supplemented diets improve antioxidant enzymes and alter acetylcholinesterase genes expression level in Drosophila melanogaster model

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