Porphyrinic MOF Film for Multifaceted Electrochemical Sensing

Abstract

Electrochemical sensors are indispensable in clinical diagnosis, biochemical detection and environmental monitoring, thanks to their ability to detect analytes in real‐time with direct electronic readout. However, electrochemical sensors are challenged by sensitivity—the need to detect low concentrations, and selectivity—to detect specific analytes in multicomponent systems. Herein, a porphyrinic metal‐organic framework (PP‐MOF), Mn‐PCN‐222 is deposited on a conductive indium tin oxide (ITO) surface. It affords Mn‐PCN‐222/ITO, a versatile voltammetric sensor able to detect redox‐active analytes such as inorganic ions, organic hazardous substances and pollutants, including nitroaromatics, phenolic and quinone‐hydroquinone toxins, heavy metal ions, biological species, as well as azo dyes. As a working electrode, the high surface area of Mn‐PCN‐222/ITO enables high currents, and therefore leverages highly sensitive analysis. The metalloporphyrin centre facilitates analyte‐specific redox catalysis to simultaneously detect more than one analyte in binary and ternary systems allowing for detection of a wide array of trace pollutants under real‐world conditions, most with high sensitivity.

Sensor Array Chip for Real‐Time Field Detection and Discrimination of Organophosphorus Neurotoxins

“…The obtained LOD for MPOx (41.4 mg/mL) is significantly higher than the AEGL‐2 for 10‐min exposure to MPOx (0.38 μg/L) [47] . Future research will thus focus on improving the detection limits of the UiO‐66/ p ‐NP sensor by improving the catalytic activity of the UiO‐66‐based catalytic reagent layer, [48,49] and by enhancing the sensitivity of the voltametric p ‐NP transducer [52] …”

“…[47] Future research will thus focus on improving the detection limits of the UiO-66/p-NP sensor by improving the catalytic activity of the UiO-66based catalytic reagent layer, [48,49] and by enhancing the sensitivity of the voltametric p-NP transducer. [52] Finally, the AChE/ChOx/H 2 O 2 amperometric inhibition biosensor performance was investigated towards the detection of three distinct OP threats, DFP (i), DCP (ii), and MPOx (iii), each at the concentration of 2.5 mM, followed by 30.33 μM of the non-OP chemical threat, As 3 + (iv) (Figure 1D). First, the AChE/ChOx/ H 2 O 2 biosensor performance was investigated towards detection of the AChCl substrate over the 2.5-25 mM range by measuring the CA oxidation current response of the enzyme cascade reaction byproduct, H 2 O 2 (Supporting Figure S8).…”

Functionalized MOF PCN-222-loaded quantum dots as an electrochemiluminescence sensing platform for the sensitive detection of p-nitrophenol

“…PCN-222 has a stable three-dimensional space structure and a one-dimensional channel. 34 The topological space structure has two stable pore sizes, including a large pore diameter of about 3.7 nm, which is one of the largest MOF apertures known. PCN-222 has high specific surface area and multi-functional groups, which can effectively disperse and anchor the loaded material.…”

Coordination networks constructed from a flexible ligand: single-crystal-to-single-crystal transformations and thermoresponsive and electrochemical performances

“…7 Among the efficient electrical energy storage (EES) devices including fuel cells, rechargeable batteries and supercapacitors (SCs), SCs have aroused extensive attention due to their high power density, quick charge-discharge capability, high safety and long recyclability, [8][9][10] leading to various utilizations such as artificial electronic skins 11 and implantable/wearable medical devices. [12][13][14] However, their lower output energy densities still severely restrict the actual application of SCs, and many efforts have been devoted to designing new electrode materials with desired structures for achieving high energy density SCs. 15,16 In contrast, to store electrical energy in electrochemical double layers (EDLs), SCs faradaically store electrical energy by redox reactions involving interfacial electron transfer between the solution and the electrode, giving rise to pseudocapacitance with higher specific/areal capacitance.…”