Porphyrins as Chelating Agents for Molecular Imaging in Nuclear Medicine

Pyrzyńska, Krystyna; Kilian, Krzysztof; Pęgier, Mateusz

doi:10.3390/molecules27103311

Cited by 10 publications

(6 citation statements)

References 92 publications

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“…In this study, 68 Ga-F127-TAPP/TCPP(Mn) NPs were obtained based on the chelation of TAPP with 68 Ga in F127-TAPP/TCPP(Mn) NPs (Figure A). The choice of the labeling conditions of the 68 Ga–porphyrin is mainly based on literature reports. , As shown in Figure B, the labeling efficiency of 68 Ga in F127-TAPP/TCPP(Mn) NPs can improved by increasing reaction temperature and time. Considering the short half-time (1.13 h) of 68 Ga, 100 °C for 15 min was selected as the optimal labeling condition (with labeling efficiency >95%).…”

Section: Resultsmentioning

confidence: 99%

Porphyrin-Based Self-Assembled Nanoparticles for PET/MR Imaging of Sentinel Lymph Node Metastasis

Fu,

Cai,

et al. 2024

ACS Appl. Mater. Interfaces

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Diagnosing of lymph node metastasis is challenging sometimes, and multimodal imaging offers a promising method to improve the accuracy. This work developed porphyrin-based nanoparticles ( 68 Ga−F127-TAPP/TCPP(Mn) NPs) as PET/ MR dual-modal probes for lymph node metastasis imaging by a simple self-assembly method. Compared with F127-TCPP(Mn) NPs, F127-TAPP/TCPP(Mn) NPs synthesized by amino-porphyrins (TAPP) doping can not only construct PET/MR bimodal probes but also improve the T 1 relaxivity (up to 456%). Moreover, T 1 relaxivity can be adjusted by altering the molar ratio of TAPP/TCPP(Mn) and the concentration of F127. However, a similar increase in T 1 relaxivity was not observed in the F127-TCPP/ TCPP(Mn) NPs, which were synthesized using carboxy-porphyrins (TCPP) doping. In a breast cancer lymph node metastasis mice model, subcutaneous injection of 68 Ga-F127-TAPP/TCPP(Mn) NPs through the hind foot pad, the normal lymph nodes and metastatic lymph nodes were successfully distinguished based on the difference of PET standard uptake values and MR signal intensities. Furthermore, the dark brown F127-TAPP/TCPP(Mn) NPs demonstrated the potential for staining and mapping lymph nodes. This study provides valuable insights into developing and applying PET/MR probes for lymph node metastasis imaging.

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Section: Resultsmentioning

confidence: 99%

Porphyrin-Based Self-Assembled Nanoparticles for PET/MR Imaging of Sentinel Lymph Node Metastasis

Fu,

Cai,

et al. 2024

ACS Appl. Mater. Interfaces

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“…However, another possibility is that TMPyP3 led to a decreased H 2 O 2 level due to the interaction of porphyrin with the cellular iron. Porphyrins are known to chelate metal ions, especially those with ionic radii of ~70 pm such as Cu(II), Fe(II), Ni(II) and Zn(II) ions [ 49 ]. The insertion of a metal ion is a very slow process, but the porphyrin complexes formed with the mentioned transition metal ions are stable [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Systemic Effects of Photoactivated 5,10,15,20-tetrakis(N-methylpyridinium-3-yl) Porphyrin on Healthy Drosophila melanogaster

Filošević Vujnović,

Čabrijan,

Mušković

et al. 2024

BioTech

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Porphyrins are frequently employed in photodynamic therapy (PDT), a non-invasive technique primarily utilized to treat subcutaneous cancers, as photosensitizing agents (PAs). The development of a new PA with improved tissue selectivity and efficacy is crucial for expanding the application of PDT for the management of diverse cancers. We investigated the systemic effects of 5,10,15,20-tetrakis(N-methylpyridinium-3-yl)-porphyrin (TMPyP3) using Drosophila melanogaster adult males. We established the oral administration schedule and demonstrated that TMPyP3 was absorbed and stored higher in neuronal than in non-neuronal extracts. Twenty-four hours after oral TMPyP3 photoactivation, the quantity of hydrogen peroxide (H2O2) increased, but exclusively in the head extracts. Regardless of photoactivation, TMPyP3 resulted in a reduced concentration of H2O2 after 7 days, and this was linked with a decreased capacity to climb, as indicated by negative geotaxis. The findings imply that systemic TMPyP3 therapy may disrupt redox regulation, impairing cellular signaling and behavioral outcomes in the process. To determine the disruptive effect of porphyrins on redox homeostasis, its duration, and the mechanistic variations in retention across various tissues, more research is required.

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“…Porphyrins are considered to be a subgroup of metalloenzymes since porphyrins also bind metal ions as part of their active sites. Well-defined porphyrin structures with controllable size and morphology exhibit great potential as electrochemical sensors [ 231 ], mediators of photocatalytic reactions [ 232 ], or chelating agents for molecular imaging [ 233 ]. Porphyrins treasure the property to create spontaneous metal–organic frameworks (MOFs) when a metal ion is present in the media [ 234 ].…”

Section: Biological Systems Affected By Magnetismmentioning

confidence: 99%

A Review of the Current State of Magnetic Force Microscopy to Unravel the Magnetic Properties of Nanomaterials Applied in Biological Systems and Future Directions for Quantum Technologies

Winkler,

Ciria,

Ahmad

et al. 2023

Nanomaterials

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Magnetism plays a pivotal role in many biological systems. However, the intensity of the magnetic forces exerted between magnetic bodies is usually low, which demands the development of ultra-sensitivity tools for proper sensing. In this framework, magnetic force microscopy (MFM) offers excellent lateral resolution and the possibility of conducting single-molecule studies like other single-probe microscopy (SPM) techniques. This comprehensive review attempts to describe the paramount importance of magnetic forces for biological applications by highlighting MFM’s main advantages but also intrinsic limitations. While the working principles are described in depth, the article also focuses on novel micro- and nanofabrication procedures for MFM tips, which enhance the magnetic response signal of tested biomaterials compared to commercial nanoprobes. This work also depicts some relevant examples where MFM can quantitatively assess the magnetic performance of nanomaterials involved in biological systems, including magnetotactic bacteria, cryptochrome flavoproteins, and magnetic nanoparticles that can interact with animal tissues. Additionally, the most promising perspectives in this field are highlighted to make the reader aware of upcoming challenges when aiming toward quantum technologies.

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Porphyrins as Chelating Agents for Molecular Imaging in Nuclear Medicine

Cited by 10 publications

References 92 publications

Porphyrin-Based Self-Assembled Nanoparticles for PET/MR Imaging of Sentinel Lymph Node Metastasis

Porphyrin-Based Self-Assembled Nanoparticles for PET/MR Imaging of Sentinel Lymph Node Metastasis

Systemic Effects of Photoactivated 5,10,15,20-tetrakis(N-methylpyridinium-3-yl) Porphyrin on Healthy Drosophila melanogaster

A Review of the Current State of Magnetic Force Microscopy to Unravel the Magnetic Properties of Nanomaterials Applied in Biological Systems and Future Directions for Quantum Technologies

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