Porphyromonas gingivalis lipopolysaccharide regulates interleukin (IL)-17 and IL-23 expression via SIRT1 modulation in human periodontal ligament cells

Park, Yong-Duk; Kim, Young-Suk; Jung, Yu-Mi; Lee, Sang‐im; Lee, Young-Man; Bang, Jae-Beum; Kim, Eun-Cheol

doi:10.1016/j.cyto.2012.05.021

Cited by 68 publications

(75 citation statements)

References 56 publications

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“…Lipopolysaccharide from the periodontopathogen Porphyromonas gingivalis induces the expression of IL-23 in human periodontal ligament cells (Park YD, et al, 2012). Furthermore, a number of IL-23 positive cells can be found already at 7 days after dental pulp exposure in Wistar rats (Hu et al, 2013).…”

Section: Interleukin-23mentioning

confidence: 99%

The role of cytokines in inflammatory bone loss

Souza

Lerner

2013

Immunological Investigations

224

231

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Chronic inflammatory processes close to bone often lead to loss of bone in diseases such as rheumatoid arthritis, periodontitis, loosened joint prosthesis and tooth implants. This is mainly due to local formation of bone resorbing osteoclasts which degrade bone without any subsequent coupling to new bone formation. Crucial for osteoclastogenesis is stimulation of mononuclear osteoclast progenitors by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL) which induces their differentiation along the osteoclastic lineage and the fusion to mature, multinucleated osteoclasts. M-CSF and RANKL are produced by osteoblasts/osteocytes and by synovial and periodontal fibroblasts and the expression is regulated by pro- and anti-inflammatory cytokines. These cytokines also regulate osteoclastic differentiation by direct effects on the progenitor cells. In the present overview, we introduce the basic concepts of osteoclast progenitor cell differentiation and summarize the current knowledge on cytokines stimulating and inhibiting osteoclastogenesis by direct and indirect mechanisms.

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Section: Interleukin-23mentioning

confidence: 99%

The role of cytokines in inflammatory bone loss

Souza

Lerner

2013

Immunological Investigations

224

231

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“…Many characteristics of these cytokines are of interest in orthodontics, since cytokines in the GCF reflect the microenvironment of periodontal tissues, in which orthodontic forces are applied [2,4,15]. Several studies also revealed that cytokines are fundamental in cell signaling in bone [14,18,19] and in mediating mechanically induced bone remodeling (e.g. by orthodontic forces) [1,2,20].…”

Section: Introductionmentioning

confidence: 99%

Cytokines in crevicular fluid and orthodontic force: a systematic review

Allgayer

Menezes

Rinaldi

2017

Rev. Odonto Ciênc. (Online)

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OBJECTIVE: This paper aimed to analyze studies in the literature addressing the role of cytokines in the gingival crevicular fluid (GCF) in the orthodontic treatment. METHODS: Several databases were surveyed using both MESH terms and free terms. Additional studies were obtained by reference tracking. This review was registered in PROSPERO, and the procedures foreseen by its statement were followed. Data were obtained from the included studies addressing the orthodontic mechanics, GCF sampling/handling methods, and cytokine measurements. Clinical studies written in English were browsed. Papers were selected by one reviewer and checked by a second investigator. RESULTS: A total of 115 articles were identified, among which 25 were selected for detailed analysis. Common drawbacks consisted mainly of inadequacies in the study design (e.g. short duration and small number of study subjects). The most consistent result was a peak of cytokine levels at 1 d. Associations were observed between prostaglandin E2 (PGE2) and interleukin-1β (IL-1β) and pain, velocity of tooth movement, and treatment mechanics. Interleukin-1b and PGE2 showed different patterns of up-regulation, with IL-1β being more responsive to mechanical stress and PGE2 more responsive to synergistic regulation of IL-1β and mechanical force. The results support the use of light continuous forces for orthodontic treatment. CONCLUSION: There was a tendency of maintenance of relatively high IL-1β levels for longer periods with the use of light continuous forces, which might decrease the frequency of activation. These outcomes provide evidence at the cellular level for the utilization of light continuous forces.Key words: Systematic review; Orthodontics, corrective; Gingival Crevicular Fluid (GCF); Interleukin; T Cells.Papel das citocinas presentes no fluido crevicular durante o tratamento ortodôntico: uma revisão sistemática REsUMO OBJETIVO: Este artigo teve como objetivo analisar estudos na literatura abordando o papel das citocinas no Líquido do Sulco Gengival no tratamento ortodôntico. MéTODOS: Várias bases de dados foram pesquisadas usando termos MESH e termos livres. Estudos adicionais foram obtidos por rastreamento de referência. Esta revisão foi registrada no PROSPERO, e os procedimentos previstos por sua declaração foram seguidos. Os dados foram obtidos dos estudos incluídos sobre a mecânica ortodôntica, métodos de amostragem / manuseio de Líquido do Sulco Gengival e medições de citoquinas. Estudos clínicos escritos em inglês foram pesquisados. Os trabalhos foram selecionados por um revisor e verificados por um segundo investigador. RESULTADOS: Foram identificados 115 artigos, dentre os quais 25 foram selecionados para análise detalhada. As desvantagens comuns consistiram principalmente em insuficiências no design do estudo (por exemplo, curta duração e pequeno número de sujeitos do estudo). O resultado mais consistente foi um pico de níveis de citocinas a 1 d. Foram observadas associações entre prostaglandina E2 (PGE2) e interleucina-1β (IL-1β) ...

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“…P. gingivalis activates the PI3K/Akt signaling pathway, which is linked to cell survival (30,31) and immune responses (32). Among several known virulence factors of P. gingivalis, both LPS and fimbriae regulate immune responses through PI3K/Akt activation in monocytes/macrophages (5,(33)(34)(35) and human gingival fibroblasts (36). Gingipains have the potential to control both cell survival and apoptosis via the PI3K/Akt pathway (37).…”

mentioning

confidence: 99%

Attenuation of the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway by Porphyromonas gingivalis Gingipains RgpA, RgpB, and Kgp

Nakayama

Inoue

Naito

et al. 2015

Journal of Biological Chemistry

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Background:The significance of gingipains on the PI3K/Akt signaling pathway is poorly understood. Results: The inactivation of PI3K and Akt was induced by P. gingivalis, which was associated with gingipains. Conclusion: Gingipains are critical for suppressing the PI3K/Akt signaling pathway via extracellular proteolysis independent of P. gingivalis invasion. Significance: This study shows the first evidence that the gingipains negatively regulate the PI3K/Akt signaling pathway.

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Porphyromonas gingivalis lipopolysaccharide regulates interleukin (IL)-17 and IL-23 expression via SIRT1 modulation in human periodontal ligament cells

Cited by 68 publications

References 56 publications

The role of cytokines in inflammatory bone loss

The role of cytokines in inflammatory bone loss

Cytokines in crevicular fluid and orthodontic force: a systematic review

Attenuation of the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway by Porphyromonas gingivalis Gingipains RgpA, RgpB, and Kgp

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