Portal and mesenteric thrombosis revealing constitutional protein C deficiency.

Thromboelastographic evaluation of coagulation in patients with extrahepatic portal vein thrombosis and non‐cirrhotic portal fibrosis: A pilot study

“…In most old series of EHO in a European and North American population, which included adult patients, an etiological factor was identifiable in up to 50% of the cases whereas the rest were labeled as idiopathic 19 . Currently, various hypercoagulable states such as deficiency of natural anticoagulants like protein C, protein S and antithrombin III, and myeloproliferative conditions have been implicated in causing EHO 20–24 . Other hypercoagulable states such as paroxysmal nocturnal hemoglobinuria, antithrombin III deficiency, heparin cofactor II deficiency and antiphospholipid syndrome have also been reported to cause portal vein thrombosis 25–28 .…”

Prothrombin gene G20210A mutation and elevated anticardiolipin antibodies in a patient with combined portal-mesenteric vein thrombosis

“…Portal and mesenteric vein thrombosis are known complications of hematological diseases [5], and coagulation disorders such as deficiencies in antithrombin III [6] and protein C [7]. It has also been attributed to increased levels of anticardiolipin antibodies [3].…”

Portal Vein Thrombosis Associated to Prothrombin G20210A Mutation and Protein C Deficiency

“…The causes of portal vein thrombosis include myeloproliferative disorders, intrabdominal neoplasia or infection, liver biopsy, splenectomy, and cirrhosis (1,2). Recent reports have described its association with deficiencies of natural anticoagulants such as protein C (3)(4)(5)(6), protein S (5-7), heparin cofactor II(8), and antithrombin (9). Association with the antiphospholipid antibody syndrome and factor V Leiden mutation has also been described (8,10-14).…”