1992
DOI: 10.1007/bf02285088
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Portal pressure, renal function and hormonal profile after acute and chronic captopril treatment in cirrhosis

Abstract: Summary.The acute effects of captopril in cirrhosis are well known but there are few descriptions of the pattern of response to chronic administration of captopril in this disease. Nine nonuraemic cirrhotic patients with ascites and portal hypertension were studied after 1 week on fixed sodium and water intake (balance diet) and following acute and chronic treatment with captopril (three doses of 25 mg every 30 min and 75 mg. day-~ for three weeks, respectively).Whilst on the balance diet, 7/9 patients were un… Show more

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Cited by 19 publications
(9 citation statements)
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“…33 In this study, blood pressure was measured with the patient in a sitting position; unfortunately, nothing is reported about the conditions of measurement in the abstract by Girgrah et al Acute administration of captopril, which as an angiotensinconverting enzyme inhibitor blocks the production of angiotensin II, caused a more pronounced decrease of arterial pressure in patients with cirrhosis than observed in the present study, but a high dosage of captopril was used. 34 Long-term treatment with captopril or enalapril did not induce a reduction in blood pressure in patients with cirrhosis. 34,35 No deterioration of renal function or electrolyte balance, as observed in the therapy of portal hypertension with other agents, 8,28 occurred during treatment with losartan.…”
Section: Discussionmentioning
confidence: 95%
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“…33 In this study, blood pressure was measured with the patient in a sitting position; unfortunately, nothing is reported about the conditions of measurement in the abstract by Girgrah et al Acute administration of captopril, which as an angiotensinconverting enzyme inhibitor blocks the production of angiotensin II, caused a more pronounced decrease of arterial pressure in patients with cirrhosis than observed in the present study, but a high dosage of captopril was used. 34 Long-term treatment with captopril or enalapril did not induce a reduction in blood pressure in patients with cirrhosis. 34,35 No deterioration of renal function or electrolyte balance, as observed in the therapy of portal hypertension with other agents, 8,28 occurred during treatment with losartan.…”
Section: Discussionmentioning
confidence: 95%
“…34 Long-term treatment with captopril or enalapril did not induce a reduction in blood pressure in patients with cirrhosis. 34,35 No deterioration of renal function or electrolyte balance, as observed in the therapy of portal hypertension with other agents, 8,28 occurred during treatment with losartan.…”
Section: Discussionmentioning
confidence: 95%
“…The full-text of 40 of these potentially relevant articles was reviewed independently. Twenty-two articles were excluded due to the lack of a control group (8/22) [18][19][20][21][22][23][24][25], the lack of HVPG measurements (12/22) [9,[26][27][28][29][30][31][32][33][34][35][36], or because they were review articles (2/22) [37,38] Fig. 1.…”
Section: Searchmentioning
confidence: 99%
“…There are a few reports evaluating the effects of captopril on portal pressure. [6][7][8][9] Significant changes in portal pressure were not detected in any of these studies. However, evaluating the previous studies on portal pressure is difficult because most of them had a small sample number without a control and had a short-term treatment regimen (less than 2 weeks).…”
Section: Discussionmentioning
confidence: 99%
“…However, previous reports on the portal hypotensive effect of an angiotensin II blockade provided conflicting results in patients with liver cirrhosis. [6][7][8][9][10][11][12][13][14] In addition, there are no reports showing the characteristics of patients who responded successfully to the angiotensin II blockade, with a fall in the hepatic venous pressure gradient (HVPG) of more than 20% of the baseline value. Captopril, an angiotensin-converting enzyme inhibitor, blocks the conversion of the inactive angiotensin I to the active form, angiotensin II.…”
Section: Introductionmentioning
confidence: 99%