Position Paper on Post-Traumatic Headache: The Relationship Between Head Trauma, Stress Disorder, and Migraine

Lambru, Giorgio; Benemei, Silvia; Andreou, Anna P.; Luciani, Michelangelo; Serafini, Gianluca; Brink, Alec Maassen van den; Martelletti, Paolo

doi:10.1007/s40122-020-00220-1

Cited by 20 publications

(21 citation statements)

References 78 publications

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“…Thus, pain is difficult to evaluate objectively because of its multifactorial nature and of the variability in the patient’s threshold. Pain threshold measurements are commonly performed by pressure, electrical or thermal responsiveness or by delivering self-reported questionnaires [ 80 , 81 ] of which the most frequently used are the WOMAC, VAS or Likert scales. Diagnostic imaging is recommended to confirm the diagnosis of OA, even though it has poor correlation with clinical pain experienced by the patient [ 82 ].…”

Section: Discussionmentioning

confidence: 99%

Gender and Sex Are Key Determinants in Osteoarthritis Not Only Confounding Variables. A Systematic Review of Clinical Data

Tschon

Contartese

Pagani

et al. 2021

JCM

138

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Many risk factors for osteoarthritis (OA) have been noted, while gender/sex differences have been understated. The work aimed to systematically review literature investigating as primary aim the relationship between gender/sex related discriminants and OA. The search was performed in PubMed, Science Direct and Web of Knowledge in the last 10 years. Inclusion criteria were limited to clinical studies of patients affected by OA in any joints, analyzing as primary aim gender/sex differences. Exclusion criteria were review articles, in vitro, in vivo and ex vivo studies, case series studies and papers in which gender/sex differences were adjusted as confounding variable. Of the 120 records screened, 42 studies were included. Different clinical outcomes were analyzed: morphometric differences, followed by kinematics, pain, functional outcomes after arthroplasty and health care needs of patients. Women appear to use more health care, have higher OA prevalence, clinical pain and inflammation, decreased cartilage volume, physical difficulty, and smaller joint parameters and dimensions, as compared to men. No in-depth studies or mechanistic studies analyzing biomarker differential expressions, molecular pathways and omic profiles were found that might drive preclinical and clinical research towards sex-/gender-oriented protocols.

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Section: Discussionmentioning

confidence: 99%

Gender and Sex Are Key Determinants in Osteoarthritis Not Only Confounding Variables. A Systematic Review of Clinical Data

Tschon

Contartese

Pagani

et al. 2021

JCM

138

View full text Add to dashboard Cite

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“…Recent structural and functional neuroimaging data have revealed that different networks other than migraine exist in persistent PTH [183]. Furthermore, calcitonin generelated peptide gene expression level is not elevated in persistent PTH, but monoclonal antibodies against calcitonin generelated peptide gene can be effective [183]. Future results from trials assessing the efficacy of such medications can provide novel treatments for PTH.…”

Section: Treatment Of Post-traumatic Headachementioning

confidence: 99%

Examining the association between traumatic brain injury and headache

Mofatteh¹

2021

J. Integr. Neurosci.

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Traumatic brain injury is a common and major cause of disability and death that might require emergency neurological and neurosurgical interventions. Traumatic brain injury can result in temporary or permanent physical, cognitive and psychological impairments. One of the most common complications associated with traumatic brain injury is post-traumatic headache, associated with significant disability and reduced quality of life. Post-traumatic headache is a public health concern that can affect the long-term outcome of traumatic brain injury patients. Clinical symptoms of post-traumatic headache significantly overlap with common primary headaches such as migraine and tension-type headaches. Beyond neurobiological factors, psychological factors can play crucial roles in the initiation and sustainment of post-traumatic headache. While neurological mechanisms underlying post-traumatic headache remains unknown, different studies suggest various mechanisms such as physical damages to the cranial nerves and neck structure, hyper-sensitization of the pain modulatory pathway, and inflammation as underlying causes for the neurobiology of headache. I explore the hypothesis that traumatic brain injury is associated with headaches. In particular, I provide an overview of the neurobiology of post-traumatic headache, its diagnosis, presenting recent findings on the etiology, explaining similarities and differences between with primary headaches such as migraine and tension-type headache, discuss pharmacological and non-pharmacological interventions for the treatments, as well as emphasising on the psychological importance of post-traumatic headache.

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“…The association between migraine and psychiatric comorbidities are complex, and influence the clinical course, treatment response and clinical outcomes [15,16]. The complexity is highlighted in a recent review regrding the impact of traumatic life events and posttraumatic stress disorder on migraine patients [16].…”

Section: Introductionmentioning

confidence: 99%

The bidirectional temporal relationship between headache and affective disorders: longitudinal data from the HUNT studies

2022

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Background Few prospective population-based studies have evaluated the bidirectional relationship between headache and affective disorder. The aim of this large-scale population-based follow-up study was to investigate whether tension-type headache (TTH) and migraine had increased risk of developing anxiety and depression after 11 years, and vice-versa. Methods Data from the Trøndelag Health Study (HUNT) conducted in 2006-2008 (baseline) and 2017-2019 (follow-up) were used to evaluate the bidirectional relationship between migraine and TTH and anxiety and depression measured by Hospital Anxiety and depression Scale (HADS). The population at risk at baseline consisted of respectively 18,380 persons with HADS score ≤ 7 and 13,893 without headache, and the prospective data was analyzed by Poisson regression. Results In the multi-adjusted model, individuals with HADS anxiety (HADS-A) and depression scores (HADS-D) of ≥8 at baseline nearly doubled the risk of migraine (Risk rations (RR) between 1.8 and 2.2) at follow-up whereas a 40% increased risk (RR 1.4) was found for TTH. Vice versa, the risk of having HADS-A and HADS-D scores of ≥8 at follow-up were increased for TTH (RR 1.3) and migraine (RR 1.3-1.6) at baseline. Migraine with aura was associated with 81% (RR 1.81, 95% 1.52-2.14) increased risk of HADS-A score of ≥8. Conclusions In this large-scale population-based follow-up study we found a bidirectional relationship between anxiety and depression and migraine and TTH. For anxiety, this bidirectional association was slightly more evident for migraine than TTH.

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Position Paper on Post-Traumatic Headache: The Relationship Between Head Trauma, Stress Disorder, and Migraine

Cited by 20 publications

References 78 publications

Gender and Sex Are Key Determinants in Osteoarthritis Not Only Confounding Variables. A Systematic Review of Clinical Data

Gender and Sex Are Key Determinants in Osteoarthritis Not Only Confounding Variables. A Systematic Review of Clinical Data

Examining the association between traumatic brain injury and headache

The bidirectional temporal relationship between headache and affective disorders: longitudinal data from the HUNT studies

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