2015
DOI: 10.4049/jimmunol.1402238
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Positional Identification ofRT1-B(HLA-DQ) as Susceptibility Locus for Autoimmune Arthritis

Abstract: Rheumatoid arthritis (RA) is associated with amino acid variants in multiple MHC molecules. The association to MHC class II (MHC-II) has been studied in several animal models of RA. In most cases these models depend on T cells restricted to a single immunodominant peptide of the immunizing Ag, which does not resemble the autoreactive T cells in RA. An exception is pristane-induced arthritis (PIA) in the rat where polyclonal T cells induce chronic arthritis after being primed against endogenous Ags. In this stu… Show more

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Cited by 25 publications
(55 citation statements)
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“…1) were less susceptible to PIA, we observed a small but reproducible difference in arthritis protection between these two strains from day 14 to day 25 ( Fig. 2A) (21). This observation suggested a putative second QTL in the nonclassical MHC-Ib and/or the MHC-III region, which was confirmed with the recombinant strain DA.1HR7, which carries a fragment from DA.1HR2 in the MHC-Ib/MHC-III region ( Fig.…”
Section: Resultssupporting
confidence: 70%
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“…1) were less susceptible to PIA, we observed a small but reproducible difference in arthritis protection between these two strains from day 14 to day 25 ( Fig. 2A) (21). This observation suggested a putative second QTL in the nonclassical MHC-Ib and/or the MHC-III region, which was confirmed with the recombinant strain DA.1HR7, which carries a fragment from DA.1HR2 in the MHC-Ib/MHC-III region ( Fig.…”
Section: Resultssupporting
confidence: 70%
“…The prefixes "HR," "UR," and "FR" indicate that the congenic fragments originate from DA.1H (RT1 h haplotype), DA.1U (RT1 u haplotype), and DA.1F (RT1 f haplotype), respectively (Materials and Methods). PIA has been previously reported in DA.1HR2, DA.1HR61, DA.1HR62, DA.1HR83, DA.1FR2, DA.1FR9, and DA.1UR2 rats (21,22). The MHC arthritis QTLs Ltab-Ncr3 and RT1-B (previously identified) (21), are shaded in brown.…”
Section: Resultsmentioning
confidence: 99%
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