Positiv-inotrope Herzwirkung von Aldadien-Kalium (Aldactone pro injectione)

Schröder, Rolf; Schüren, K. P.; Biamino, Giancarlo; Meyer, V.; Sadée, Wolfgang

doi:10.1007/bf01732923

Cited by 22 publications

(4 citation statements)

References 13 publications

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“…SchrSder and colleagues [8] have shown increase in cardiac output, stroke volume, and the estimated rate of left ventricular pressure development in patients with congestive heart failure given spironolactone. Tanz and colleagues [9,10] demonstrated an increase in the contractile force of papillary muscle preparations following the administration of spironolactone.…”

Section: Discussionmentioning

confidence: 98%

“…It is generally accepted that spironolactone possesses a positive inotropic action [11]. The first-pass metabolism of spironolactone results in several metabolites, one of which, canrenoate, has been reported to possess a positive inotropic action in humans and animals [8,12,13]. In vitro evidence of positive inotropic effects of canrenoate are conflicting [6,14,15].…”

Section: Discussionmentioning

confidence: 99%

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Amiloride improves hemodynamics in patients with chronic congestive heart failure treated with chronic digoxin and diuretics

Cheitlin

Byrd

Benowitz

et al. 1991

Cardiovasc Drug Ther

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Potassium-sparing diuretics have been reported to decrease the positive inotropic effect of digoxin. We studied the hemodynamic effects of amiloride in patients taking digoxin for chronic heart failure. Eleven men with a history of congestive heart failure were studied in a double blind, cross-over, placebo controlled trial with the patients on digoxin alternating placebo with amiloride. After 7 days on the trial drug, a Swan-Ganz catheter was placed in the pulmonary artery and measurements made at rest and with increasing degrees of supine bicycle exercise. Right-sided and pulmonary artery wedge pressures and systemic arterial pressures, as well as cardiac outputs, were measured. After a 7 day washout period, placebo (P) and Amiloride (A) were switched and after 7 days on the therapy, a second hemodynamic study at rest and varying degrees of supine bicycle exercise was repeated. At rest there were no significant differences in the right-sided, pulmonary arterial wedge pressure or cardiac outputs between the patients on Amiloride (A) versus placebo (P). During exercise there were significant differences between (P) and (A) at the 50 watt-second stage of exercise.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Amiloride improves hemodynamics in patients with chronic congestive heart failure treated with chronic digoxin and diuretics

Cheitlin

Byrd

Benowitz

et al. 1991

Cardiovasc Drug Ther

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show abstract

“…Vermehrt verabfolgte oder durch den Operationsstreß gebildete Katecholamine können zusätzlich die Aldosteron-Inkretion steigern. Weiterhin wird durch die intra-und postoperativ vermehrte ACTH-Inkretion direkt die Aldosteron-Synthese stimuliert (21,30). Aus alledem wird ersichtlich, daß durch schonende Narkose-und Operationsverfahren der Aldosteronismus gemildert werden kann.…”

Section: Pathophysiologic Des Aldosteronismusunclassified

“…Neben den bekannten Effekten der Aldosteronantagonisten werden in neuerer Zeit noch weitere spezifisch kardiale Effekte diskutiert. Aldosteronantagonisten wirkten positiv inotrop (30), sie setzen die toxische Wirkung von Digitalis herab (30a) und verkürzen die Refraktärzeit (13). Eine positiv inotrope Wirkung wurde zuerst am isolierten Papillarmuskel der Katze nachgewiesen (34), sie kann also nicht oder nicht ausschließlich durch extrakardiale Effekte bedingt sein.…”

Section: Störungen Des Elektrolyt-und Wasserhaushaltesunclassified