Positive Association between Basal Total Testosterone Circulating Levels and Tumor Grade Groups at the Time of Diagnosis of Prostate Cancer

Porcaro, Antonio Benito; Tafuri, Alessandro; Sebben, Marco; Pirozzi, Marco; Processali, Tania; Rizzetto, Riccardo; Amigoni, Nelia; Shakir, Aliasger; Tiso, Leone; Cerrato, Clara; Panunzio, Andrea; Michele, Mario De; Cerruto, Maria Angela; Brunelli, Matteo; Migliorini, Filippo; Siracusano, Salvatore; Artibani, Walter

doi:10.1159/000500960

Cited by 10 publications

(7 citation statements)

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“…In n previous series, we showed that elevated basal TT levels were associated with high-grade tumors in a pathologic specimen [18, 19]. Subsequently, in a contemporary set of patients, we showed that higher preoperative TT levels were directly associated with upgrading in low-intermediate risk classes using the D’Amico criteria as well as higher biopsy ISUP groups [6]; furthermore, basal TT levels were related to the risk of focal and non-focal positive surgical margins by linear extent [5]. This data was confirmed by a study in an Asian population, in which metastatic PCA was found to be associated with significantly higher basal TT levels and an even higher elevation in non-metastatic cases [20].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the relationship between preoperative testosterone serum levels and PCA stage and grade is debated. Indeed, some evidence suggests a linear correlation between preoperative androgen levels and the aggressiveness of PCA [5, 6]. However, other authors have found that low levels of testosterone are associated with more aggressive PCA [7, 8].…”

Section: Introductionmentioning

confidence: 99%

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Association between Basal Total Testosterone Levels and Prostate Cancer D’Amico Risk Classes

et al. 2020

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Objective: To test the hypothesis that basal total testosterone (TT) serum levels are associated with the D'Amico risk classification at diagnosis of prostate cancer (PCA). Materials and Methods: From November 2014 to March 2018, preoperative basal levels of TT and prostate-specific antigen (PSA) were measured in 601 consecutive PCA patients who were not under androgen deprivation therapy or undergoing prior prostate surgery. Patients were classified into low (reference group), intermediate, and high risk classes according to biopsy findings. The association of TT and other clinical factors with risk classes was evaluated using a multivariate multinomial logistic regression model. Results: According to the D'Amico classification, 124 patients (24%) were low risk, 316 (52.6%) were intermediate risk, and 141 (23.4%) were high risk. Median basal TT circulating levels were significantly increased along clinical risk classes. TT along with PSA, percentage of biopsy positive cores, and tumor clinical stage were independently associated with a high risk (OR = 1.002; p = 0.022) but not with an intermediate risk of PCA when compared to the low risk class. In the intermediate-risk group, endogenous TT together with PSA were independently associated with tumor grade groups 2 (OR = 1.003; p = 0.022) and 3 (OR = 1.003; p = 0.043) compared to grade group 1 cancers. Conclusions: Basal TT levels are positively associated with the D'Amico risk classification, but the association is significant for the high-risk group compared to the low-risk group.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between Basal Total Testosterone Levels and Prostate Cancer D’Amico Risk Classes

et al. 2020

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“…27,28 In an previous series, we showed that elevated basal TT levels were associated with high grade tumors in pathologic specimens. 29,30 Subsequently, in a contemporary set of patients, we showed that higher preoperative TT levels were directly associated with upgrading in low-intermediate risk classes using the D'Amico criteria as well as higher biopsy ISUP groups 6 ; furthermore, basal TT levels were related to the risk of focal and non-focal positive surgical margins in a linear manner. 5,31 In the present study, we have shown that there is an independent positive association between basal TT and the risk of aggressive PCA in the surgical specimen.…”

Section: <00001mentioning

confidence: 89%

“…Indeed, some studies suggests a linear correlation between preoperative androgen levels and aggressveness of PCA. [4][5][6] On the contrary, other authors found that low levels of testosterone are associated with more aggressive PCA. [7][8][9] It is known that many emerging chronic diseases, such as obesity, 10,11 may influence testosterone levels in middle-aged men either by directly influencing the hypothalamic-pituitary-testicular axis or through a peripheral effect.…”

Section: Introductionmentioning

confidence: 92%

Basal total testosterone serum levels predict biopsy and pathological ISUP grade group in a large cohort of Caucasian prostate cancer patients who underwent radical prostatectomy

Tafuri

Sebben

Rizzetto

et al. 2020

Therapeutic Advances in Urology

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Aims: The study aimed to evaluate associations of preoperative total testosterone (TT) with the risk of aggressive prostate cancer (PCA). Materials & methods: From 2014 to 2018, basal TT levels were measured in 726 consecutive PCA patients. Patients were classified according to the International Society of Urologic Pathology (ISUP) system. Aggressive PCA was defined by the detection of ISUP > 2 in the surgical specimen. The logistic regression model evaluated the association of TT and other clinical factors with aggressive PCA. Results: On univariate analysis, there was a significant association of basal TT with the risk of aggressive PCA as well as age, prostate-specific antigen (PSA), percentage of biopsy positive cores (BPC), tumor clinical stage (cT), and biopsy ISUP grade groups. On multivariate analysis, two models were considered. The first (model I) excluded biopsy ISUP grading groups and the second (model II) included biopsy ISUP grade groups. Multivariate model I, revealed TT as well as all other variables, was an independent predictor of the risk of aggressive disease [odds ratio (OR) = 1.585; 95% confidence interval (CI): 1.113–2.256; p = 0.011]. Elevated basal PSA greater than 20 µg/dl was associated with the risk of aggressive PCA. Multivariate model II revealed that basal TT levels maintain a positive association between aggressive PCA, whereas age, BPC, and clinical stage cT3 lost significance. In the final adjusted model, the level of risk of TT did not change from univariate analysis (OR = 1.525; 95% CI: 1.035–2.245; p = 0.011). Conclusion: Elevated preoperative TT levels are associated with the risk of aggressive PCA in the surgical specimen. TT may identify patients who are at risk of aggressive PCA in the low and intermediate European Association of Urology (EAU) risk classes.

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“…Після виконаного варіаційного дисперсійного й кореляційного аналізу зроблено висновки, що мають практичну спрямованість: виконання ПТ з енергією фотонів 6 МЕВ показано хворим при рівні LT < 2,5 мО/мл (< M-SD хворих на РПЗ); у Слід зазначити, що при РПЗ гонадотропний LT регулює процеси канцерогенезу [9]. Тестостеронемія прямо корелює з агресивним перебігом РПЗ [7,8] і тісно пов'язана із структурними морфологічними особливостями пухлинного процесу [18]. А тому існує нагальна необхідність зниження рівня TS в крові при РПЗ андрогендепресивними препаратами [19,20].…”

Section: обговоренняunclassified

Гормональные Маркеры Рака Предстательной Железы И Лечение Больных

Syniachenko¹,

Paliy²,

Dumansky³

et al. 2021

Mìžnarodnij endokrinologìčnij žurnal

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Актуальность. В структуре онкологической патологии у мужчин рак предстательной железы (РПЖ) занимает лидирующие позиции, при этом является второй по частоте причиной смерти в случаях злокачественных новообразований. Заболеваемость и смертность от РПЖ, который относится к гормонозависимым опухолям, во всем мире ежегодно увеличиваются. Среди биомаркеров опухолевого процесса при РПЖ обсуждаются такие половые и гонадотропные гормоны, как тестостерон (TS) и лютеинизирующий гормон (лютропин, LТ). Отчасти сказанное касается функционального аналога инсулина — белкового инсулиноподобного фактора роста 1 (ISF). Цель исследования: оценить клинико-прогностическую значимость гормональных опухолевых маркеров (TS, LT, ISF) в крови больных РПЖ. Материалы и методы. Под наблюдением находились 195 мужчин с РПЖ в возрасте от 52 до 82 лет. Критериями исключения были больные с патологическим процессом менее второй стадии. Продолжительность с момента диагностики заболевания составила от 5 месяцев до 17 лет. Аденокарцинома диагностирована у 94 % от числа обследованных больных, метастазы в лимфатических узлах выявлены в 39 % случаев, в отдаленных органах — в 19 %, в скелете — в 28 %. Уровни в сыворотке крови TS и LT изучали методом иммунохимического анализа, а содержание ISF — иммуноферментного анализа. Результаты. Повышение уровня таких гормональных маркеров РПЖ, как TS и ISF, наблюдается в крови соответственно у 46 и 100 % от числа больных, зависит от характера течения опухолевого процесса и его метастазирования. Пятилетняя выживаемость больных РПЖ зависит от исходного уровня критерия Глисона, методики проводимой лучевой терапии и параллельного назначения антиандрогенной гормональной терапии. В процессе проведенных лечебных мероприятий достоверно уменьшается содержание в крови гормональных маркеров опухолевого процесса (TS, LT, ISF), что определяется исходным характером течения заболевания. Выводы. Изученные гормональные биомаркеры РПЖ участвуют в патогенетических построениях заболевания и обладают диагностической и прогностической значимостью в процессе проведения лечебных мероприятий.

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Positive Association between Basal Total Testosterone Circulating Levels and Tumor Grade Groups at the Time of Diagnosis of Prostate Cancer

Cited by 10 publications

References 0 publications

Association between Basal Total Testosterone Levels and Prostate Cancer D’Amico Risk Classes

Association between Basal Total Testosterone Levels and Prostate Cancer D’Amico Risk Classes

Basal total testosterone serum levels predict biopsy and pathological ISUP grade group in a large cohort of Caucasian prostate cancer patients who underwent radical prostatectomy

Гормональные Маркеры Рака Предстательной Железы И Лечение Больных

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