Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study

Li, Minghui; Zhan, Aihua; Huang, Xiao; Hu, Lihua; Zhou, Wei; Wang, Tao; Zhu, Lingjuan; Bao, Huihui; Cheng, Xiaoshu

doi:10.21203/rs.3.rs-31909/v2

Cited by 13 publications

(24 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IR plays a key role in the occurrence and development of hyperuricemia. As a new, simple but effective substitute for IR, the TyG index has been proved to be associated with a variety of cardiovascular diseases and related risk factors, including peripheral vascular disease, ischemic heart disease, coronary artery calci cation, and arterial stiffness [30][31][32] . Previous studies reported that the TyG index may also be used as a risk index for hyperuricemia, and our results were supported by it.…”

Section: Discussionmentioning

confidence: 99%

Mediation effect of obesity on the association between triglyceride-glucose index and hyperuricemia in Chinese hypertension adults.

Sun

et al. 2021

Preprint

View full text Add to dashboard Cite

Background and Aims: The triglyceride glucose (TyG) index was regarded as a simple surrogate marker of insulin resistance (IR). It is confirmed that IR was significantly associated with hyperuricemia, and obesity was the risk factor for IR and hyperuricemia. However, the relationship between the TyG index and hyperuricemia and the potential role of obesity in Han Chinese hypertension are not entirely elucidated.Methods and Results： A community-based cross-sectional study was conducted in 4551 hypertension patients aged 40-75 years with clinical and biochemical data. The TyG index was calculated as ln [fasting triglyceride (mg/dl) × fasting blood glucose (mg/dl)/2]. Hyperuricemia was determined as serum uric acid ≥357μmol/L (6 mg/dl) for females and ≥417μmol/L (7 mg/dl) for males. The TyG index was higher in patients with hyperuricemia than in those without (8.99±0.61, 8.70±0.59, P<0.001). The prevalence of hyperuricemia in patients with the lowest (≤8.32), second (8.33-8.66), third (8.67-9.07) and the highest quartile (≥9.08) of the TyG index was 6.0%, 10.4%, 15.4%, 21.4%, respectively. Logistic regression analysis suggested that the higher quartile of TyG index was associated with increased hyperuricemia risk whether in crude or adjusted models (P<0.05). Mediation analysis showed that all of our obesity indexes partially mediated the association between the TyG index and hyperuricemia to some extent.Conclusion：TyG index is significantly associated with hyperuricemia in hypertension patients among Han Chinese, obesity plays a partial mediation role in this relationship.

show abstract

Section: Discussionmentioning

confidence: 99%

Mediation effect of obesity on the association between triglyceride-glucose index and hyperuricemia in Chinese hypertension adults.

Sun

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…All subjects in the present study were participants in the ongoing China H-type hypertension Registry Study (Registration number: ChiCTR1800017274).The data collection approaches and the established standards of inclusion or exclusion have been described previously [37,38]. Briefly, the study is a real-world, multicenter, observational study, conducted in March 2018 at Wuyuan, Jiangxi province of China.…”

Section: Participantsmentioning

confidence: 99%

“…Participants received this measurement after at least 5 min of rest in the supine position in a quiet room. The measurement approaches of baPWV and ABI related to this study have been described previously [37,38]. The average of baPWV measured on bilateral limbs of each patient was used for analysis.…”

Section: Measurement Of Bapwv and Definition Of Arterial Stiffnessmentioning

confidence: 99%

Does body mass index or waist-hip ratio correlate with arterial stiffness based on brachial-ankle pulse wave velocity in Chinese rural adults with hypertension?

Yu²,

Han

et al. 2021

BMC Cardiovasc Disord

Self Cite

View full text Add to dashboard Cite

Background The relationship between obesity indices and arterial stiffness (AS) has not been fully discovered nor has it been studied in depth in large hypertensive patient populations. The aim of this study was to explore the association between body mass index (BMI) and waist-hip ratio (WHR) levels and AS based on brachial-ankle pulse wave velocity (baPWV) in Chinese rural adults with hypertension. Methods This cross-sectional study analyzed 5049 Chinese rural adults with essential hypertension. BMI was calculated as the body weight in kilograms divided by the square of the height in meters (kg/m2). Central obesity was defined as WHR ≥ 0.9 for males and ≥ 0.85 for females. Measurement of arterial stiffness was carried out via brachial-ankle pulse wave velocity (baPWV). Results The prevalence of overweight, general obesity, central obesity and increased AS were 26.88%, 3.39%, 63.85% and 44.01%, respectively. Multivariate logistic regression analysis indicated that BMI levels were negatively associated with the prevalence of increased AS (adjusted-OR per SD increase: 0.74, 95% CI 0.67–0.81, P < 0.001). When BMI was instead treated as a categorical variable divided into tertiles, the same relationship was observed (P for trend < 0.001). Inversely, WHR levels were positively associated with the prevalence of increased AS (adjusted-OR per SD increase: 1.25, 95% CI 1.14–1.36, P < 0.001). Compared to subjects without central obesity, those with central obesity had a higher prevalence of increased AS (adjusted-OR: 1.52, 95% CI 1.28–1.81, P < 0.001). Linear regression models indicated similar results in the correlation between BMI or WHR levels and baPWV levels (adjusted-β per SD increase: − 0.57, 95% CI − 0.68 to − 0.46, P < 0.001; adjusted-β per SD increase: 4.46, 95% CI 3.04–5.88, P < 0.001). There were no interactions in terms of age and blood pressure on the relationship between BMI or WHR levels and the prevalence of increased AS or baPWV levels. Conclusion There was an inverse relationship between BMI levels and increased AS or baPWV levels, whereas WHR levels and central obesity were positively associated with increased AS or baPWV levels in Chinese rural adults with hypertension.

show abstract

“…Clinical approaches have traditionally been used to measure IR [12][13][14]. However, the relationship between the TyG index and baPWV is controversial [15][16][17][18][19]. In clinical practice, baPWV is used as a simple and reliable tool to measure arterial stiffness because of its high reproducibility [20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

The Correlation of Atherosclerosis and Triglyceride Glucose Index: A Secondary Analysis of a National Cross-Sectional Study of Japanese

Yang¹,

Gao²,

Huang³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: The triglyceride/glucose index (TyG index) has been suggested as a simple and reliable surrogate insulin resistance (IR) marker for years. However, the association between the TyG index and arterial stiffness in adults is controversial. Therefore, we evaluated this relationship, as measured based on the brachial ankle pulse wave velocity (baPWV), in Japanese adults.Methods: This study selected a total of 912 participants from the NAGALA (NAfld in Gifu Area, Longitudinal Analysis) study conducted from 2004 to 2012.The relationship between TyG index and baPWV was estimated through a logistics model. Subgroup analyses by gender, age, body mass index (BMI), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), estimated glomerular filtration rate (eGFR), and fatty liver were performed. The formula for TyG index was ln [½fasting triglyceride level (mg/dL) × fasting plasma glucose level (mg/dL)].Results: After adjusting for underlying confounders, a linear relationship between TyG and baPWV was discovered. After adjusting for gender, age, body mass index, systolic blood pressure, diastolic blood pressure, high-density lipoprotein cholesterol, fatty liver, and eGFR, TyG, as a continuous variable, was related to an increased risk of baPWV (adjusted odds ratio [adj OR], 1.57; 95% confidence interval [95% CI], 1.14–2.18). Compared with the the TyG index in the first tertile, the probabilities of subjects in the third tertile that developed to baPWV were 1.78-fold higher (adj OR 1.78, 95% CI 1.08–2.95; P for trend 0.024). Stable associations were also observed between the TyG index and baPWV in different variables through subgroup analyses.Conclusions: The TyG index was positively and linearly related to subclinical atherosclerosis in Japanese adults and may be valuable as a predicted marker.

show abstract

Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study

Cited by 13 publications

References 23 publications

Mediation effect of obesity on the association between triglyceride-glucose index and hyperuricemia in Chinese hypertension adults.

Mediation effect of obesity on the association between triglyceride-glucose index and hyperuricemia in Chinese hypertension adults.

Does body mass index or waist-hip ratio correlate with arterial stiffness based on brachial-ankle pulse wave velocity in Chinese rural adults with hypertension?

The Correlation of Atherosclerosis and Triglyceride Glucose Index: A Secondary Analysis of a National Cross-Sectional Study of Japanese

Contact Info

Product

Resources

About