Positive association of Apolipoprotein E4 polymorphism with recurrent pregnancy loss in Iranian patients

Asgari, Nooshin; Akbari, Mohammad Taghi; Zare, Shohre; Babamohammadi, Gholamreza

doi:10.1007/s10815-012-9897-5

Cited by 16 publications

(22 citation statements)

References 28 publications

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“…While crossing these studies we paid attention to the statistical heterogeneity; if I 2 values were low or moderate (I 2 <50 %), the fixed-effect model was considered for use, otherwise the random-effect model was adopted where the heterogeneity was high among these statistics. In order to assess heterogeneity, we used the I 2 based Q statistic for each genetic contrast to describe the weighted sum of the squared difference and a p-value less than 0.10 was considered in-homogeneous among the included studies [23]. Publication bias was assessed using Begg's unweighted regression test and funnel plots [5].…”

Section: Discussionmentioning

confidence: 99%

“…With thorough evaluation, 431 studies were excluded for inappropriate research, contents that were either not relevant or did not investigate related genes with recurrent pregnancy loss, 16 were retrieved which described the association between the Apo E polymorphism and RPL, and finally, 6 were eligible for meta-analysis [15,17,19,20,23,24]. One of the studies was excluded because the samples were not maternal blood, the tissue used was fetal tissue material [21]; five were excluded because they were presented as a "letter to the editor", meaning that the contents were controversial regarding the association between recurrent pregnancy loss and apolipoprotein E [14,16,[25][26][27]; three were not included because they did not present detailed genotyping information [2,18,28]; and another study was excluded because it concentrated on patients with endometriosis [29].…”

Section: Characteristicsmentioning

confidence: 99%

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Apolipoprotein E (Apo E) gene polymorphisms and recurrent pregnancy loss: a meta-analysis

Chen

et al. 2013

J Assist Reprod Genet

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Background Recently, a relationship between recurrent pregnancy loss (RPL) and Apolipoprotein E (Apo E) gene polymorphisms has been proposed. In order to investigate the real association between Apo E polymorphisms and RPL, our meta-analysis was carried out. Methods We estimated the association with RPL risk under dominant and recessive models, in combination with the OR and RR with a 95 % confidence interval (CI), which was used to assess the association between RPL and Apo E polymorphisms. Results According to our criterion, there were 6 studies included. The dominant model used the E4/E3 group and the OR was 1.919 (95 %CI: 1.016-3.625, I 2 =53.8 %), the RR was 1.308 (95 %Cl: 1.071-1.598) suggesting that carriers of the E4 allele would have a higher risk of causing spontaneous miscarriages. In addition, the OR was 0.727 (95 %CI: 0.566-0.932, I 2 =0.0 %) and RR was 0.923 (95 %CI: 0.867-0.982) in a fixed model for E3/E3 homozygotes versus other genotypes, suggesting that the Apo E3 polymorphism could be a protective factor. The OR was 1.365 (95 % CI: 1.029-1.811, I 2 =0 .0 %) in a fixed model comparing the E2 allele with the E3 allele, suggesting that Apo E2 polymorphisms may contribute to RPL as a risk factor. Furthermore, after conducting sensitivity analysis in the E4/E3 group, the results showed this to be consistent and the OR was 2.249 (95 %CI: 1.474-3.431). Conclusions There is a close association between RPL and Apo E gene polymorphisms. For RPL, the Apo E4 polymorphism could be a risk factor, the Apo E3 polymorphism may be a protective factor and the Apo E2 polymorphism may be another potential risk factor.

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Section: Discussionmentioning

confidence: 99%

Section: Characteristicsmentioning

confidence: 99%

Apolipoprotein E (Apo E) gene polymorphisms and recurrent pregnancy loss: a meta-analysis

Chen

et al. 2013

J Assist Reprod Genet

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“…Five publications met the inclusion criteria [8][9][10][11][12]. In Ozdemir et al, the ORs were presented separately for the three different subgroups (i.e., women with a history of RPL, RPL male partners, and RPL patients with no gender restriction) [11].…”

Section: Study Characteristicsmentioning

confidence: 99%

Association between apolipoprotein E gene polymorphism and the risk of recurrent pregnancy loss: A meta-analysis

Meng

Mei

Yuan-yuan

et al. 2013

J Assist Reprod Genet

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Purpose The association between apolipoprotein E (ApoE) gene polymorphism and the risk of recurrent pregnancy loss (RPL) remains controversial. The present meta-analysis was performed to derive a precise estimate of the relationship. Method(s) We searched the PubMed, Embase, and Web of Science data-bases for studies related to the association between the ApoE genotype and the risk of RPL. We estimated the summary odds ratio (OR) with 95% confidence interval (CI) to assess the association. Result(s) Seven studies, including 2,090 RPL cases and 742 control samples, were identified. The results showed a significant association between ApoE E4 mutation and RPL risk (for E4 allele: OR =1.98, 95 %CI =1.14-3.43, P=0.499; for E2E3 vs. E3E3: OR =1.33, 95%CI =1.12-1.42, P=0.008; for E2E4 vs. E3E3: OR =1.26, 95 % CI =1.07-1.49, P=0.005). Conclusion(s)The meta-analysis suggests an association between ApoE E4 mutation and increased risk of RPL.

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“…APOE has three allelic variants including E2–4. It has been reported that there was a significant higher frequency of allele E4 among a subpopulation of Iranian RPL patients compared with non‐RPL cases (Asgari, Akbari, Zare, & Babamohammadi, ; Poursadegh Zonouzi, Farajzadeh, Bargahi, & Farajzadeh, ). Hypercoagulable state increases the thrombophilia which can be maintained by factors involving in coagulation system and folate metabolism (Blanco‐Molina et al, ).…”

Section: Thrombophiliamentioning

confidence: 99%

Genetics of recurrent pregnancy loss among Iranian population

Moghbeli

2019

Molec Gen & Gen Med

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Background Recurrent pregnancy loss (RPL) is one of the most common reproductive disorders which is defined as the occurrence of recurrent miscarriage before 24 weeks of gestation and is observed among 1%–5% of women. Methods Various factors are associated with RPL such as immunological disorders, maternal age, obesity, alcohol, chromosomal abnormality, endocrine disorders, and uterine abnormalities. About half of the RPL cases are related with chromosomal abnormalities. Therefore, RPL genetic tests are mainly limited to karyotyping. However, there is a significant proportion of RPL cases without any chromosomal abnormalities that can be related to the single‐gene aberrations. Therefore, it is required to prepare a diagnostic panel of genetic markers besides karyotyping. Results In the present review, we have summarized all the significant reported genes until now which are associated with RPL among Iranian women. We categorized all the reported genes based on their cellular and molecular functions in order to determine the molecular bases of RPL in this population. Conclusion This review paves the way of introducing a population‐based diagnostic panel of genetic markers for the first time among Iranian RPL cases. Moreover, this review clarifies the genetic and molecular bases of RPL in this population.

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Positive association of Apolipoprotein E4 polymorphism with recurrent pregnancy loss in Iranian patients

Cited by 16 publications

References 28 publications

Apolipoprotein E (Apo E) gene polymorphisms and recurrent pregnancy loss: a meta-analysis

Apolipoprotein E (Apo E) gene polymorphisms and recurrent pregnancy loss: a meta-analysis

Association between apolipoprotein E gene polymorphism and the risk of recurrent pregnancy loss: A meta-analysis

Genetics of recurrent pregnancy loss among Iranian population

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