Positive Association of D Allele of ACE Gene With High Altitude Pulmonary Edema in Indian Population

Bhagi, Shuchi; Srivastava, Swati; Tomar, Arvind; Singh, Shashi Bala; Sarkar, Shubhashish

doi:10.1016/j.wem.2014.09.010

Cited by 16 publications

(12 citation statements)

References 35 publications

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“…In the present study on 418 patients from western Black Sea region of Turkey, however, ACE gene I/D polymorphism and ACE gene alleles were not found to be associated with liver fibrosis severity. The ACE gene DD genotype is thought to be associated with an increased risk of rheumatic heart disease in the Saudi population (Al-Harbi et al, 2015), with nitric oxide metabolite levels and systolic blood pressure in clinically healthy Mexican men (no effect in women) (Avila-Vanzzini et al, 2015), with high altitude pulmonary edema in an Indian population (Bhagi et al, 2015), with sepsis susceptibility in Chinese patients (Yang and Zhou, 2015), with periodontal disease susceptibility in a Korean population (Kang et al, 2015), and with cancer risk in Caucasians (Zhang et al, 2014). It has been suggested that ACE gene I/D polymorphism is a genetic risk factor for Alzheimer's disease in a Chinese population (Yuan et al, 2015), while there is reportedly no association between ACE I/D gene polymorphism and a number of conditions and associated risks including type 1 diabetic nephropathy (T1DN) susceptibility and the risk of patients with type 1 diabetes mellitus developing T1DN in a Caucasian population , chronic obstructive pulmonary disease (Ayada et al, 2014) and retinal vein occlusion (Kutlutürk et al, 2014) in a Turkish population, as well as type 2 diabetic nephropathy (T2DN) susceptibility and the risk of patients with type 2 diabetes mellitus developing T2DN in Caucasian populations .…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme gene polymorphism (insertion/deletion) and liver fibrosis in Turkish patients from the western Black Sea region, Turkey

Nk¹,

Su²,

Ac³

et al. 2015

Genet. Mol. Res.

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Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme gene polymorphism (insertion/deletion) and liver fibrosis in Turkish patients from the western Black Sea region, Turkey

Nk¹,

Su²,

Ac³

et al. 2015

Genet. Mol. Res.

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“…Abnormal expression of ACE in rats resulted in inflammation, pulmonary edema and histological changes in smoke inhalation-induced lung injury (31). In humans, the I/D polymorphism of the ACE gene has been associated with the development of high altitude pulmonary edema (32). The I/D ACE polymorphism has been demonstrated to be independent of thrombosis formation (33); however, it may be associated with osteoporosis (34), panic disorder (35) and vitiligo (36).…”

Section: Discussionmentioning

confidence: 99%

Alterations in ACE and ABCG2 expression levels in the testes of rats subjected to atropine-induced toxicity

Huang

Yang

et al. 2016

Molecular Medicine Reports

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Atropine-induced damage is associated with enzyme and protein alterations. The aim of the present study was to investigate atropine‑induced alterations in testicular expression levels of angiotensin‑converting enzyme (ACE) and adenosine 5'-triphosphate binding cassette sub‑family G member 2 (ABCG2) following atropine treatment. Male Wistar rats received 15 mg/kg/day atropine for 7 days; control rats received an identical volume of saline, Following treatment, the testes were harvested for immunohistochemistry and in situ hybridization to examine the protein and gene expression levels of ACE and ABCG2 by digital image analysis. ACE gene and protein expression levels were significantly reduced in the testes of atropine‑treated rats, compared with control rats (P=0.0001 and P<0.001, respectively). In addition, ABCG2 gene and protein expression levels were significantly increased in the testes of atropine‑treated rats, compared with control rats (P=0.0017 and P<0.001, respectively). Thus, the results of the present study demonstrate that testicular protein and gene expression levels of ACE and ABCG2 were altered as a result of atropine‑induced toxicity in the rats. These alterations may result in abnormal testicular function, and the proteins and genes identified in the present study may be useful to elucidate the mechanisms underlying atropine‑induced toxicity and provide a direction for further studies.

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“…A total of 304 cases and 564 controls were included in the pooled analysis. [10][11][12][13][14][15][16][17] The study characteristics are summarized in Table 1. Genotype distribution was consistent with HWE in the controls of all studies.…”

Section: Study Characteristicsmentioning

confidence: 99%

Angiotensin-converting enzyme gene insertion/deletion polymorphism and high-altitude pulmonary edema: An updated meta-analysis

Zheng

Huang

2020

J Renin Angiotensin Aldosterone Syst

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Objective: The purpose of the study was to investigate the association between angiotensin-converting enzyme gene insertion/deletion polymorphism and high-altitude pulmonary edema. Methods: A systematic search for relevant literature was performed in MEDLINE, CNKI, and EMBASE. The pooled odds ratios and their corresponding 95% confidence intervals were calculated in STATA 12.0 software. Results: Seven studies, with a total of 304 patients and 564 controls, qualified for the inclusion in the analysis. There was no significant association between angiotensin-converting enzyme insertion/deletion polymorphism and high-altitude pulmonary edema risk in the total population (DD vs II: odds ratio=1.07, 95% confidence interval 0.52–2.24; DI vs II: odds ratio=1.12, 0.85–1.49; dominant model: odds ratio=1.07, 0.83–1.40; recessive model: odds ratio=0.96, 0.53–1.77). Subgroup analysis according to race also revealed no significant correlation between angiotensin-converting enzyme gene insertion/deletion polymorphism and high-altitude pulmonary edema. Conclusions: Our findings suggest that angiotensin-converting enzyme insertion/deletion polymorphism does not contribute to the risk of high-altitude pulmonary edema. Larger, well-designed studies are required to further validate these results.

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Positive Association of D Allele of ACE Gene With High Altitude Pulmonary Edema in Indian Population

Abstract: These findings demonstrate a possible association of the I/D polymorphism of the ACE gene with the development of HAPE, with D/D being the at-risk genotype.

Cited by 16 publications

References 35 publications

Angiotensin-converting enzyme gene polymorphism (insertion/deletion) and liver fibrosis in Turkish patients from the western Black Sea region, Turkey

Angiotensin-converting enzyme gene polymorphism (insertion/deletion) and liver fibrosis in Turkish patients from the western Black Sea region, Turkey

Alterations in ACE and ABCG2 expression levels in the testes of rats subjected to atropine-induced toxicity

Angiotensin-converting enzyme gene insertion/deletion polymorphism and high-altitude pulmonary edema: An updated meta-analysis

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