Positive association of herpes simplex virus-IgG with multiple sclerosis: A systematic review and meta-analysis

Xu, Lu; Zhang, Linjie; Yang, Li; Yang, Chun-Sheng; Yi, Ming; Zhang, Shengnan; Wang, Nan; Huang, Chen-Na; Liu, Mingqi

doi:10.1016/j.msard.2020.102633

Cited by 18 publications

(15 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pediatric metabolic syndrome data from [18,19] provided evidence that HSV-1 IgG positive serostatus associated with increased risk of paediatric metabolic syndrome Moreover, another study reported that seropositivity IgG against HSV were detected in 26% paediatric onset metabolic syndrome [20]. In a recent study, sub-group analysis suggested that the seroprevalence of IgG against HSV-1 was significantly increased in the paediatric patients combined with metabolic syndrome compared with the controls [21].…”

Section: Discussionmentioning

confidence: 99%

Relation between herpes simplex type 1 and metabolic syndrome in Ismailia primary school children

Ragab

Gomaa

Anani

2022

Advances in Environmental and Life Sciences

View full text Add to dashboard Cite

Metabolic syndrome is defined as the co-occurrence of several cardiovascular risk factors, containing, insulin resistance, obesity, atherogenic dyslipidemia, and hypertension. Herpes simplex virus is an intracellular pathogen that can affect the skin of several parts of the body including the urogenital region, -mouth, eyes, and nervous system, which is life-threatening for children. The present study aimed to assess the percent of antibody of herpes simplex virus type 1 among children with metabolic syndrome (diabetes and obesity) in Primary schools in Ismailia city. Thus, a cross-sectional study was conducted on 46 children from age 6 to 10 years old in Ismailia city. Our method depend on dictation of herpes simplex virus type 1 antibodies (IgG) by commercial ELISA techniques. Serum triglyceride HD, L, LDL and fast blood sugar were measured by using colorimetric assay in accordance with a standardized method, they were analyzed through spectrophotometer Semi-Automatic clinical chemistry analyzer (Micro lab 300-ELITechGroup). In present study we found that a very high frequency of HSV-1 infections among the studied metabolic syndrome children with a percentage of 86% while the control group (children of the same gender and age) were 26% only. Upon the interpretation of the HSVs serological profiles, the past latent infection with HSV-1 (IgG was the most prevalent type of infection than HSV-1 recurrent infection (IgM) (0%), in all the HSV-1 positive cases (n= 46, 56%). Moreover, then there weakly positive correlation between IgG and triglycerides which is significant statistically (p< 0.05), while non-significant statistically correlation with HDL and LDL, Cholesterol, while ruling out the equivocal sample as HSV-1 IgM negative. The current study suggested that a very high incidence of HSV-1 antibodies among metabolic syndrome children in Ismailia city.

show abstract

Section: Discussionmentioning

confidence: 99%

Relation between herpes simplex type 1 and metabolic syndrome in Ismailia primary school children

Ragab

Gomaa

Anani

2022

Advances in Environmental and Life Sciences

View full text Add to dashboard Cite

show abstract

“…The results described above are supported by recent findings in the literature, which suggest an association between herpes simplex virus (HSV) encephalitis and AD, 10 11 AD and hepatitis, 12 13 genital warts and dementia, 14 EBV and dementia, 15 and MS and HSV. 16 Since the discovery of an association of the 1918 flu pandemic, caused by H1N1 influenza A, with postencephalitic parkinsonism, a link between influenza and PD has been debated. 17 A recent study using Danish data found an association between influenza and PD with an odds ratio of 1.73 up to 10 years after virus exposure.…”

Section: Discussionmentioning

confidence: 99%

Virus exposure and neurodegenerative disease risk across national biobanks

Levine

Leonard

Blauwendraat

et al. 2022

Preprint

View full text Add to dashboard Cite

BACKGROUND With recent findings connecting Epstein-Barr virus to increased risk of multiple sclerosis and growing concerns regarding the potential neurological impact of the coronavirus pandemic, we surveyed biobank scale real-world data to identify potential links between viral exposures and neurodegenerative disease risks. METHODS To assess the potential increased risk of neurodegenerative diseases due to viral exposures, we mined time series data from FinnGen as a discovery dataset and cross-sectional data from the UK Biobank as a replication dataset for 73 pairs of common viral exposures and neurodegenerative disease outcomes. We investigated the impact of time span between viral exposure and disease risk using time series data from FinnGen at 1, 5, and 15 year intervals between exposure and disease onset. This analysis helped us to avoid the potential confounding of concurrent diagnosis due to hospitalization with viral infection. Further, to address the possible bias of reverse causality we examined risk for severe viral infections after NDD diagnosis. RESULTS We identified 45 viral exposures significantly associated with increased risk of post-exposure neurodegenerative disease onset after multiple test correction in the discovery phase using longitudinal data. 22 of these associations were replicated in cross sectional data from the UK Biobank. The largest effect association we saw replicated was between viral encephalitis exposure and Alzheimer's disease, with discovery hazard estimates of ~30 and a replication odds ratio of ~22. We also replicated the association between Epstein-Barr virus exposure and multiple sclerosis 5-15 years before diagnosis of multiple sclerosis. In total, 17 virus/neurodegeneration pairs were significant with 5-15 years between viral exposure and NDD diagnosis. In an investigation of potential confounding and reverse causality, we generally see larger hazard ratios associated with viruses preceding NDD diagnosis than viruses post NDD diagnosis. CONCLUSIONS Viral exposures contribute to later in life risk of neurodegenerative disease with increased risk of neurodegeneration still significant at up to 15 years between some events in this report.

show abstract

“…As mentioned, NDFIP functions as regulatory proteins of Nedd4-family E3 ligases 11 , 12 . Herpes simplex virus (HSV) is a common neurotropic virus that is capable of long latencies, can cause focal demyelination, and it has been described more frequently in MS cases than controls 25 . The HSV-2 protein UL56 is also a regulatory protein of Nedd4 E3 ligases, specifically involved in protein stability, and promotes proteasome-mediated degradation by increasing ubiquitination of Nedd4 26 .…”

Section: Discussionmentioning

confidence: 99%

Genetic variation in NDFIP1 modifies the metabolic patterns in immune cells of multiple sclerosis patients

López-Cotarelo

González-Jiménez

Agudo-Jiménez

et al. 2021

Sci Rep

View full text Add to dashboard Cite

One of the 233 polymorphisms associated with multiple sclerosis (MS) susceptibility lies within the NDFIP1 gene, and it was previously identified as eQTL in healthy controls. NDFIP1 shows interesting immune functions and is involved in the development of the central nervous system. We aimed at studying the NDFIP1 variant on activation and metabolism of immune cells. NDFIP1 mRNA and protein expression were assessed in PBMCs by qPCR and western blot in 87 MS patients and 84 healthy controls genotyped for rs4912622. Immune activation after PHA stimulation was evaluated by CD69 upregulation, and metabolic function of both basal and PHA-activated lymphocytes was studied by Seahorse Xfp-Analyzer. In minor-allele homozygous controls but not in patients, we found higher NDFIP1 expression, significantly reduced protein levels, and CD69 upregulation in B- and T-cells. PBMCs from minor-allele homozygous controls showed significantly higher basal mitochondrial respiration and ATP production compared to major-allele carriers, while minor-allele homozygous patients showed significantly lower metabolic activity than carriers of the major allele. In conclusion, we describe associations in minor-allele homozygous controls with lower levels of NDFIP1 protein, CD69 upregulation, and raised mitochondrial activity, which are not replicated in MS patients, suggesting a NDFIP1 differential effect in health and disease.

show abstract

Positive association of herpes simplex virus-IgG with multiple sclerosis: A systematic review and meta-analysis

Cited by 18 publications

References 40 publications

Relation between herpes simplex type 1 and metabolic syndrome in Ismailia primary school children

Relation between herpes simplex type 1 and metabolic syndrome in Ismailia primary school children

Virus exposure and neurodegenerative disease risk across national biobanks

Genetic variation in NDFIP1 modifies the metabolic patterns in immune cells of multiple sclerosis patients

Contact Info

Product

Resources

About