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Background: Primary infertility and secondary infertility of men in the reproductive age represent 1.9 and 10.5%, respectively. Many etiological factors are involved, among which urogenital bacterial infections play an important role. Materials and Methods:Semen analysis, bacteriological culture, and sensitivity analyses were carried out to investigate the effect of genitourinary infections on semen parameters of infertile men. Results: Staphylococcus aureus was the most common isolated pathogen (46.2%) followed by urogenic gram-negative pathogens (24.1%). The isolated microorganisms are highly sensitive to piperacillin/tazobactam, imipenem, meropenem, gentamicin, doxycycline, amikacin, and nitrofurantoin. These antibiotics could be used empirically while awaiting the results of semen culture. Conclusion: Semen culture is an important diagnostic tool in all patients undergoing fertility investigations to detect genitourinary infections, pyospermia, and bacteriospermia. Moreover, early treatment should be considered according to the results of culture whenever possible. Wide range of broad-spectrum antibiotics can be used as an empirical treatment for infertile patients to adjust the seminal parameters and reduce the number of leukocytes in semen ejaculates.

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Introduction: The increasing incidence of methicillin resistance among Staphylococci has led to renewed interest in the usage of macrolide-lincosamide-streptogramin B (MLSB) antibiotics to treat S. aureus infections, with clindamycin being the preferable agent owing to its excellent pharmacokinetic properties. Inducible clindamycin resistance my lead to therapeutic failure. Aim: Detection of the prevalence of constitutive and inducible clindamycin resistance in clinical isolates of S. aureus to improve the clinical outcomes in patients. Methodology: A total of 176 non-duplicate staphylococcal isolates were isolated from different clinical samples. Methicillin resistance was detected using Cefoxitin disk diffusion (CDD) method. Phenotypic clindamycin resistance was performed for all isolates by D test. Polymerase Chain Reaction (PCR) assay were done for detection of erm resistance genes (ermA, ermB and ermC). Results: Out of 176 strains of S. aureus, 108 isolates (61.3%) were identified as MRSA. Erythromycin and clindamycin resistance was detected in 96 isolates (54.5%) and 68 isolates (38.6%) respectively. Clindamycin resistance (cMLSB) was significantly higher (p value < 0.001) in MRSA strains (56 isolates) compared to MSSA (12 isolates). Resistant genes were detected in 160 isolates (91%). The ermA gene was detected in 28 isolates (16%), the ermB gene was detected in 80 isolates (45.5%) (p < 0.001). Conclusions and recommendations: The frequency of constitutive and inducible clindamycin resistance in MRSA isolates emphasizes the need to use D test in routine antimicrobial susceptibility testing to detect the susceptibility to clindamycin as the inducible resistance phenotype can inhibit the action of clindamycin and affect the treatment efficacy.