Seasonal, regional, and storm-scale variations of cloud-to-ground (CG) lightning characteristics in Florida are presented. Strong positive CG (1CG) and negative CG (2CG) flashes (i.e., having large peak current) are emphasized since they often are associated with strong storms, structural damage, and wildfire ignitions. Although strong 2CG flashes are most common during the warm season (May-September) over the peninsula, the greatest proportion of strong 1CG flashes occurs during the cool season (October-April) over the panhandle. The warm season exhibits the smallest 1CG percentage but contains the greatest 1CG flash densities, due in part to more ambiguous 1CG reports (15-20 kA). The more frequent occurrence of ambiguous 1CG reports helps explain the unusually small average 1CG peak current during the warm season, whereas strong 1CG reports (.20 kA) appear to be responsible for the greater average warm season 1CG multiplicity. The 2CG flash density, multiplicity, and peak current appear to be directly related, exhibiting their greatest values during the warm season when deep storms are most common. A case study examines the atmospheric conditions and storm-scale processes associated with two distinct groups of storms on 13-14 May 2007. Although these groups of storms form in close proximity, several factors combine to produce predominately strong 1CG and 2CG flashes in the northern (south Georgia) and southern (north Florida) regions, respectively. Results suggest that heat and smoke very near preexisting wildfires are key ingredients in producing reversed-polarity (1CG dominated) storms that often ignite subsequent wildfires.