Positive contrast visualization of iron oxide‐labeled stem cells using inversion‐recovery with ON‐resonant water suppression (IRON)

Stuber, Matthias; Gilson, Wesley D.; Schär, Michael; Kedziorek, Dorota; Hofmann, Lawrence V.; Shah, Saurabh; Vonken, Evert Jan; Bulte, Jeff W.M.; Kraitchman, Dara L.

doi:10.1002/mrm.21399

Cited by 209 publications

(216 citation statements)

References 17 publications

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“…70 Unfortunately, these techniques do not eliminate the signal loss or magnetic susceptibility artifacts, but rather exploit them to generate more easily perceived bright images of the contrast effects, often at the expense of the surrounding anatomical detail. Moreover, the undesirable 24-72 h delay between injection of the agent and the imaging result remains.…”

mentioning

confidence: 99%

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

Estelrich¹,

Sánchez-Martín²,

Busquets³

2015

IJN

281

106

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Magnetic resonance imaging (MRI) has become one of the most widely used and powerful tools for noninvasive clinical diagnosis owing to its high degree of soft tissue contrast, spatial resolution, and depth of penetration. MRI signal intensity is related to the relaxation times ( T 1 , spin–lattice relaxation and T 2 , spin–spin relaxation) of in vivo water protons. To increase contrast, various inorganic nanoparticles and complexes (the so-called contrast agents) are administered prior to the scanning. Shortening T 1 and T 2 increases the corresponding relaxation rates, 1/ T 1 and 1/ T 2 , producing hyperintense and hypointense signals respectively in shorter times. Moreover, the signal-to-noise ratio can be improved with the acquisition of a large number of measurements. The contrast agents used are generally based on either iron oxide nanoparticles or ferrites, providing negative contrast in T 2 -weighted images; or complexes of lanthanide metals (mostly containing gadolinium ions), providing positive contrast in T 1 -weighted images. Recently, lanthanide complexes have been immobilized in nanostructured materials in order to develop a new class of contrast agents with functions including blood-pool and organ (or tumor) targeting. Meanwhile, to overcome the limitations of individual imaging modalities, multimodal imaging techniques have been developed. An important challenge is to design all-in-one contrast agents that can be detected by multimodal techniques. Magnetoliposomes are efficient multimodal contrast agents. They can simultaneously bear both kinds of contrast and can, furthermore, incorporate targeting ligands and chains of polyethylene glycol to enhance the accumulation of nanoparticles at the site of interest and the bioavailability, respectively. Here, we review the most important characteristics of the nanoparticles or complexes used as MRI contrast agents.

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mentioning

confidence: 99%

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

Estelrich¹,

Sánchez-Martín²,

Busquets³

2015

IJN

281

106

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“…Further MR technology development to improve T2* quantification accuracy and consistency is important and is expected to be feasible (162)(163)(164). Another possibility will be to exploit the T1 relaxation enhancement of SPIO by T1 weighted MR sequences, and therefore the positive (bright) enhancement of SPIO (162,165). The further wider use of quantitative susceptibility mapping (QSM) or wider spread of even higher magnetic strength such as 7 Tesla is likely both to reduce the required dosage of SPIO agents as well as the quantification accuracy of local iron concentration.…”

Section: Other Selected Applications Of Ferucarbotran and Ferumoxytolmentioning

confidence: 99%

A comprehensive literatures update of clinical researches of superparamagnetic resonance iron oxide nanoparticles for magnetic resonance imaging

Wáng

Idée

2017

Quant. Imaging Med. Surg.

199

116

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“…This leads to challenges differentiating blood product from labeled cells in an injured IVD. Novel MRI methodology has been adopted to help differentiate the labeled cells from endogenous substances, such as Inversion-Recovery With ON-Resonant Water Suppression, which delineates SPION labeled cells as positive contrast [102] . Further novel sequences are being developed to provide an exciting possibility to enhance non-invasive cell tracking.…”

Section: Issues With Cell Labelingmentioning

confidence: 99%

Mesenchymal stem cell tracking in the intervertebral disc

Handley

Goldschlager

Oehme

et al. 2015

WJSC

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Low back pain is a common clinical problem, which leads to significant social, economic and public health costs. Intervertebral disc (IVD) degeneration is accepted as a common cause of low back pain. Initially, this is characterized by a loss of proteoglycans from the nucleus pulposus resulting in loss of tissue hydration and hydrostatic pressure. Conservative management, including analgesia and physiotherapy often fails and surgical treatment, such as spinal fusion, is required. Stem cells offer an exciting possible regenerative approach to IVD disease. Preclinical research has demonstrated promising biochemical, histological and radiological results in restoring degenerate IVDs. Cell tracking provides an opportunity to develop an in-depth understanding of stem cell survival, differentiation and migration, enabling optimization of stem cell treatment. Magnetic Resonance Imaging (MRI) is a non-invasive, non-ionizing imaging modality with high spatial resolution, ideally suited for stem cell tracking. Furthermore, novel MRI sequences have the potential to quantitatively assess IVD disease, providing an improved method to review response to biological treatment. Superparamagnetic iron oxide nanoparticles have been extensively researched for the purpose of cell tracking. These particles are biocompatible, non-toxic and act as excellent MRI contrast agents. This review will explore recent advances and issues in stem cell tracking and molecular imaging in relation to the IVD.

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Positive contrast visualization of iron oxide‐labeled stem cells using inversion‐recovery with ON‐resonant water suppression (IRON)

Cited by 209 publications

References 17 publications

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

A comprehensive literatures update of clinical researches of superparamagnetic resonance iron oxide nanoparticles for magnetic resonance imaging

Mesenchymal stem cell tracking in the intervertebral disc

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