Positive effect of dietary soy in ESRD patients with systemic inflammation—correlation between blood levels of the soy isoflavones and the acute-phase reactants

Fanti, Paolo; Asmis, Reto; Stephenson, Tammy; Sawaya, B. Peter; Franke, Adrian A.

doi:10.1093/ndt/gfl169

Cited by 118 publications

(103 citation statements)

References 18 publications

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“…In addition, an anti-inflammatory and nutritional effect has also been observed in patients with end-stage renal disease that received isoflavone-containing soy-based nutritional supplements (7). In this regard, we have also previously shown that the progression rate to renal injury in obese Zucker rats was decreased by consumption of a soy protein diet (39).…”

Section: Discussionmentioning

confidence: 82%

Renoprotective mechanisms of soy protein intake in the obese Zucker rat

Trujillo¹,

Cruz²,

Tovar³

et al. 2008

American Journal of Physiology-Renal Physiology

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We previously showed that long-term consumption of a soy protein diet (SoyP) reduces renal damage in obese Zucker (ObeseZ) rats by restoring urinary NO 2 and NO 3 excretion (UNO2/NO3V), suggesting that nitric oxide (NO) deficiency may contribute to the renal progression observed in this model. In addition, there is compelling evidence that hyperleptinemia produced deleterious effects on the kidney through its interaction with the short leptin receptor (ObRa). This study was designed to evaluate the contribution of the NO/endothelial NO synthase (eNOS) system, renal oxidative stress, and ObRa expression to the renoprotection conferred by the consumption of a SoyP in ObeseZ rats. Ten lean and ten male ObeseZ rats were included. One-half of each group was fed with a 20% SoyP and the other half with a 20% casein protein diet (CasP) over the course of 160 days. eNOS protein levels and phosphorylation, renal lipoperoxidation (rLPO), and antioxidant enzyme activity were assessed. In addition, renal ObRa, TGF-␤, and kidney injury molecule (Kim-1) mRNA levels, as well as urinary Kim-1 levels, were measured. Renal injury observed in ObeseZ rats fed with CasP was not associated with changes in eNOS expression or phosphorylation. However, this group did present with increased rLPO, reduced catalase activity, and upregulation of ObRa, TGF-␤1, and Kim-1. In contrast, ObeseZ rats fed with a SoyP exhibited a reduction in NOS-Thr495 phosphorylation and rLPO, as well as an enhanced catalase activity. These findings were associated with a significant reduction of ObRa, TGF-␤1, and Kim-1 mRNA levels and urinary Kim-1 protein. Our results show that renoprotection by SoyP in ObeseZ rats is in part mediated by increased NO availability secondary to a reduction in eNOS-T495 phosphorylation and oxidative stress, together with a significant reduction in ObRa and TGF-␤ expression. oxidative stress; nitric oxide; endothelial nitric oxide synthase phosphorylation; short leptin receptor

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Section: Discussionmentioning

confidence: 82%

Renoprotective mechanisms of soy protein intake in the obese Zucker rat

Trujillo¹,

Cruz²,

Tovar³

et al. 2008

American Journal of Physiology-Renal Physiology

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“…Increases in total isoflavones, genistein and daidzein (59) and genistein levels (63) induced by long-term soya consumption were not associated with CRP reductions (59,63) . When pure molecules were utilized, CRP and IL-8 were lowered by quercetin supplementation in runners (64) and bikers (65) , while quercetin plasma levels increased.…”

Section: Anti-inflammatory Properties Of Flavonoidsmentioning

confidence: 76%

“…Long-term intervention studies conducted using soya as a source of bioactive molecules showed reduction in levels of vascular cell adhesion molecule-1 and CRP (59,60) , but also a lack of effect on CRP (61)(62)(63) , TNFa (61,63) and IL-6 (60,62) . Increases in total isoflavones, genistein and daidzein (59) and genistein levels (63) induced by long-term soya consumption were not associated with CRP reductions (59,63) .…”

Section: Anti-inflammatory Properties Of Flavonoidsmentioning

confidence: 99%

Flavonoids as anti-inflammatory agents

2010

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Epidemiological evidence suggests that a high intake of plant foods is associated with lower risk of chronic diseases. However, the mechanism of action and the components involved in this effect have not been identified clearly. In recent years, the scientific community has agreed to focus its attention on a class of secondary metabolites extensively present in a wide range of plant foods: the flavonoids, suggested as having different biological roles. The antiinflammatory actions of flavonoids in vitro or in cellular models involve the inhibition of the synthesis and activities of different pro-inflammatory mediators such as eicosanoids, cytokines, adhesion molecules and C-reactive protein. Molecular activities of flavonoids include inhibition of transcription factors such as NF-kB and activating protein-1 (AP-1), as well as activation of nuclear factor-erythroid 2-related factor 2 (Nrf2). However, the in vitro evidence might be somehow of limited impact due to the non-physiological concentrations utilized and to the fact that in vivo flavonoids are extensively metabolized to molecules with different chemical structures and activities compared with the ones originally present in the food. Human studies investigating the effect of flavonoids on markers of inflammation are insufficient, and are mainly focused on flavonoid-rich foods but not on pure molecules. Most of the studies lack assessment of flavonoid absorption or fail to associate an effect on inflammation with a change in circulating levels of flavonoids. Human trials with appropriate placebo and pure flavonoid molecules are needed to clarify if flavonoids represent ancillary ingredients or key molecules involved in the anti-inflammatory properties of plant foods.

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“…Hemodiyaliz tedavisi alan ve CRP düzeyi yüksek (>10.0 mg/l) olan son evre böbrek yetmezliği hastalarında 8 hafta boyunca soya isoflavonları suplemantasyonu (diyaliz sonrası soya bazlı içecek (54 mg isoflavon) ve diğer günlerde tahıllı ürün (26 mg isoflavon) veya proteinli bar (26 mg isoflavon)) yapılmıştır. Sekiz haftanın sonunda test grubunda kan isoflavon düzeylerinin kontrol grubuna göre 5-10 kat daha yüksek olduğu ve CRP düzeyinin başlangıca oranla daha düşük olduğu gösterilmiştir (87).…”

Section: Flavonoidlerunclassified

Kronik Böbrek Hastalığında Renal İnflamasyon ve Bazı Güncel Diyet Bileşenleri İlişkisi

Öztürk¹,

Nergiz-Unal²

2018

Turk Neph Dial Transpl

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ÖZKronik böbrek hastalığı, glomerüler filtrasyonun azalmasıyla böbrekte sıvı-solüt dengesinin düzenlen-mesi ve metabolik-endokrin fonksiyonlarda kronik ve ilerleyici bozulma hali olarak tanımlanabilir. Kronik böbrek hastalığı gelişiminde rol alan inflamasyon, kronik böbrek hastalığının sonucu olarak da ortaya çıkabilmekte ve KBH varlığına bağlı mortalite artışının en önemli nedenlerinden biri olarak kabul edilmektedir. İnflamasyon ve diyet etkileşimi ile ilgili yapılan güncel araştırmalar çoklu doymamış yağ asitleri, D vitamini, E vitamini gibi besin ögeleri ile karnitin, lipoik asit, flavanoidler, probiyotikler ve prebiyotikler gibi diğer diyet bileşenlerinin renal inflamasyon sürecindeki olumlu etkilerine işaret etmektedir. Derlemede, olası anti-inflamatuvar bazı diyet bileşenlerinin kronik böbrek hastalığı ile ilişkili inflamasyon üzerine etkileri incelenmiştir. ANAHTAR SÖZCÜKLER: Kronik böbrek hastalığı, Beslenme, İnflamasyon, Diyet ABSTRACTChronic kidney disease can be defined as chronic and progressive deterioration of the regulation of fluid-solute balance and metabolic-endocrine functions of the kidney due to diminishing glomerular filtration. Inflammation in renal disease can develop as a cause or an outcome, and it has been reported in recent studies that inflammation is among the most important causes of disease-related mortality. Investigations on inflammation and diet interactions have shown that the effects of nutrients such as polyunsaturated fatty acids, vitamin D, vitamin E and other dietary components such as carnitine, lipoic acid, flavanoids, probiotics and prebiotics may have positive effects on the renal inflammation process. In this review, the potential anti-inflammatory effects of some current dietary components in chronic kidney disease were studied.

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Positive effect of dietary soy in ESRD patients with systemic inflammation—correlation between blood levels of the soy isoflavones and the acute-phase reactants

Abstract: These data suggest the possibility of beneficial effects of isoflavone-rich soy foods on the inflammatory and nutritional status of HD patients with underlying systemic inflammation.

Cited by 118 publications

References 18 publications

Renoprotective mechanisms of soy protein intake in the obese Zucker rat

Renoprotective mechanisms of soy protein intake in the obese Zucker rat

Flavonoids as anti-inflammatory agents

Kronik Böbrek Hastalığında Renal İnflamasyon ve Bazı Güncel Diyet Bileşenleri İlişkisi

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