Positive effect of platelet rich fibrin on osseointegration

Abstract

BackgroundLeukocyte-platelet rich fibrin (L-PRF) is a second generation platelet concentrate clinically used to accelerate tissue healing and bone regeneration. Achieving reduced implant osseointegration time could provide immediate or early loading of implants. The aim of this study was to evaluate the L-PRF-induced osseointegration and bone-implant contact (BIC) in an experimental animal model.Material and MethodsTwelve 4-month-old New Zealand white rabbits were used. Following general anesthesia, 3-5 mL of blood was obtained from the central artery in rabbit ear and L-PRF was prepared. Two implant cavities (5 mm long and 3 mm in diameter) were created in each tibia with a total of four cavities in each animal. Two of these cavities were selected and covered with PRF (test group). The remaining L-PRF was used to soak the implants placed into the L-PRF covered sockets. Other cavities were left as controls. In total, 48 implants were placed. Animals were sacrificed after two, three, or four weeks. Histological samples were obtained and peri-implant tissues were histomorphometrically evaluated for bone-to-implant contact and new bone formation.ResultsHistomorphometric analyses of the defects revealed that the L-PRF was detectable up to the second week. Application of L-PRF increased the rate and amount of new bone formation in the experimental group compared to the control group. Bone-to-implant contact was enhanced when the surface was pre-wetted with L-PRF (p<0.01).ConclusionsThe results of this study demonstrated that L-PRF application may increases amount and rate of new bone formation during the early healing period and provides a faster osseointegration around implants. Key words:Dental implants, platelet rich fibrin, osseointegration, bone regeneration, matrix for growth factors.

Effects of leukocyte‐ and platelet‐rich fibrin associated or not with bovine bone graft on the healing of bone defects in rats with osteoporosis induced by ovariectomy

“…Some studies have demonstrated that L‐PRF compressed clot alone produced favorable clinical outcomes in the treatment of infrabony periodontal defects (Chang et al, ; Zhao et al, ; Sharma and Pradeep, ; Ajwani et al, ; Chandradas et al, ), protected open wounds in the oral cavity (Asaka et al, ), sped up the healing of hard and soft tissues (Marenzi et al, ; Simon et al, ; Boora et al, ; Tunali et al, ; Eren et al, ; Kotsakis et al, ), reduced the rates of alveolitis after tooth extractions (Eshghpour et al, ; Kumar et al, ), and improved BV in preprosthetic surgeries and the osseointegration of dental implants (Oncu and Erbeyoglu, ; Castro et al, ; Cortese et al, ; Kanayama et al, ; Aoki et al, ; Oncu and Alaaddinoglu, ; Oncu et al, ; Boora et al, ; Simon et al, ).…”

Assessment of the effectiveness of platelet rich fibrin in the treatment of Schneiderian membrane perforation

“…In addition to the positive effect on soft and hard tissue healing, PRF can be used for its antihemorrhagic effects. These effects are important in reducing edema after surgery …”

“…These effects are important in reducing edema after surgery. [22][23][24] When the collagen membrane and PRF are compared, PRF has natural adhesive property. [22][23][24] It has high resistance due to the fibrin network in PRF and this feature can prevent graft particles from escaping into the sinus membrane.…”

Immediate Dental Implants Enriched with L-PRF in the Esthetic Zone

“…Membranes were also introduced to separate tissues. Recent research clearly indicates that L-PRF (leukocyte-platelet-rich fibrin, a second generation of platelet concentrates) significantly enhances wound healing in both soft and hard tissues [4–6].…”