Positive effect of strontium‐oxide layer on the osseointegration of moderately rough titanium surface in non‐osteoporotic rabbits

Abstract

The strontium-oxide layer on the SLA surface has the potential to improve implant osseointegration in non-osteoporotic rabbits.

Strontium‐incorporated titanium implant surface treated by hydrothermal reactions promotes early bone osseointegration in osteoporotic rabbits

“…This was in accordance with the present experiment that showed that a significantly lower BIC% and BA% around the implants were found in osteoporotic bone compared with healthy bone. Regarding the effect of the Sr‐incorporated surface, it was found that the SLA‐Sr surface had the potential to improve bone‐to‐implant osseointegration in non‐osteoporotic models in our previous studies (Chen et al, ; Fan et al, ; Zhou et al, ), which was confirmed in the current study. Furthermore, SLA‐Sr implants displayed better effects on bone formation compared with SLA implants in osteoporotic animals, which was in accordance with other reports (Offermanns et al, ; Rohnke et al, ), indicating that Sr ions do have positive effects on promoting early osseointegration not only in healthy animals but also in osteoporotic animals.…”

“…Immediately after specimen harvest, femur samples with implants were embedded in a quadrate metal box on an electronic torsion testing machine (CTT2500; MTS Company). This testing equipment measured the gradually increasing force value in Newton centimetres (Ncm) required to loosen the implant from the bone sample, as previously reported (Fan et al, ). The compression force was applied at a speed of 5°/min, and the peak removal torque force was recorded by a single‐blinded and experienced examiner.…”

“…Commercial, pure Ti plates (Grade 4 Ti targets with a purity of 99.5%) and one hundred and twenty‐eight screw‐shaped pure Ti implants (Φ 4 × 8 mm, bone level implants) were friendly supplied by Zhejiang Guangci Medical Appliance Company. These Ti samples were prepared as described previously (Chen et al, ; Fan et al, ). Briefly, Ti samples were polished, sandblasted and acid‐etched with HNO 3 /HF and HCl/H 2 SO 4 and were considered as the SLA group.…”

“…The resulting Ti‐Sr surface contains both microscale porous and nanoscale particles, which could enhance the bone cell response in vitro and bone osseointegration in vivo (Li et al, ; Park, Kwon, & Suh, ). Our previous in vitro and in vivo studies also demonstrated that Sr‐incorporated surfaces through simple hydrothermal treatment had a positive influence on mesenchymal stem cell (MSC) differentiation and enhanced implant osseointegration in healthy animals (Chen, Chen, Shen, He, & Liu, ; Fan et al, ; Zhou et al, ). However, information about the bone response to Sr in osteoporotic animals is still limited.…”

Loading deproteinized bovine bone with strontium enhances bone regeneration in rat calvarial critical size defects

“…More recently, several experimental studies have shown promising results in terms of increased bone formation after Sr enrichment of various bone substitute materials, such as allogeneic bone [19], bioactive bioglass [20,21], calciumsilicon ceramic [22], calcium phosphate [23,24], and hydroxyapatite [25,26]. Furthermore, it was observed in recent experiments that Sr-loaded titanium implants presented significantly increased bone-to-implant contact, comparing to control implants [27][28][29]. Thus, another approach to enhance the bone regenerative potential of DBB may be to combine it with strontium (Sr).…”