Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma

Yi, Peng; Wu, Bin; Deng, Da; Zhang, Guang Nian; Li, Jian Shui

doi:10.3892/ol.2018.9295

Cited by 10 publications

(12 citation statements)

References 30 publications

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“…Some ZFPs have also been reported as prognostic factors in HCC. For example, the high expression of ZBTB20 and ZNF689 in HCC patients was strongly associated with poor clinical prognosis as well as high recurrence rates [ 154 , 155 ]. In a latest study, Sun et al revealed that zinc finger protein 2 gene (ZIC2) was able to predict the prognosis of HCC, and ZIC2 was positively correlated with immune infiltration cells in HCC patients [ 156 ].…”

Section: Discussionmentioning

confidence: 99%

Structures and biological functions of zinc finger proteins and their roles in hepatocellular carcinoma

Han

Zhang

et al. 2022

Biomark Res

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Zinc finger proteins are transcription factors with the finger domain, which plays a significant role in gene regulation. As the largest family of transcription factors in the human genome, zinc finger (ZNF) proteins are characterized by their different DNA binding motifs, such as C2H2 and Gag knuckle. Different kinds of zinc finger motifs exhibit a wide variety of biological functions. Zinc finger proteins have been reported in various diseases, especially in several cancers. Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated death worldwide, especially in China. Most of HCC patients have suffered from hepatitis B virus (HBV) and hepatitis C virus (HCV) injection for a long time. Although the surgical operation of HCC has been extremely developed, the prognosis of HCC is still very poor, and the underlying mechanisms in HCC tumorigenesis are still not completely understood. Here, we summarize multiple functions and recent research of zinc finger proteins in HCC tumorigenesis and progression. We also discuss the significance of zinc finger proteins in HCC diagnosis and prognostic evaluation.

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Section: Discussionmentioning

confidence: 99%

Structures and biological functions of zinc finger proteins and their roles in hepatocellular carcinoma

Han

Zhang

et al. 2022

Biomark Res

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“…ZNF689, also known as TIPUH1, promotes the progression of hepatocellular carcinoma by suppressing the apoptotic signaling, and a high ZNF689 level indicates a poor prognosis of hepatocellular carcinoma [ 59 , 60 ]. Recently, ZNF689 was shown as a direct regulator of pancreatic cancer cell invasion and migration [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Low Levels of TRIM28-Interacting KRAB-ZNF Genes Associate with Cancer Stemness and Predict Poor Prognosis of Kidney Renal Clear Cell Carcinoma Patients

Czerwińska

Maćkiewicz

2021

Cancers

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Krüppel-associated box zinc finger (KRAB-ZNF) proteins are known to regulate diverse biological processes, such as embryonic development, tissue-specific gene expression, and cancer progression. However, their involvement in the regulation of cancer stemness-like phenotype acquisition and maintenance is scarcely explored across solid tumor types, and to date, there are no data for kidney renal clear cell cancer (KIRC). We have harnessed The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) database transcriptomic data and used several bioinformatic tools (i.e., GEPIA2, GSCALite, TISIDB, GSEA, CIBERSORT) to verify the relation between the expression and genomic alterations in KRAB-ZNFs and kidney cancer, focusing primarily on tumor dedifferentiation status and antitumor immune response. Our results demonstrate a significant negative correlation between KRAB-ZNFs and kidney cancer dedifferentiation status followed by an attenuated immune-suppressive response. The transcriptomic profiles of high KRAB-ZNF-expressing kidney tumors are significantly enriched with stem cell markers and show a depletion of several inflammatory pathways known for favoring cancer stemness. Moreover, we show for the first time the prognostic role for several KRAB-ZNFs in kidney cancer. Our results provide new insight into the role of selected KRAB-ZNF proteins in kidney cancer development. We believe that our findings may help better understand the molecular basis of KIRC.

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“…Recent studies have shown that ZNF689 is a C2H2 type zinc finger protein (zinc finger proteins, ZNFs), and the abnormal expression of this gene is involved in the occurrence and development of a variety of tumors ( 26 ). The expression of ZNF689 is significantly increased in liver cancer tissues, and the positive expression of ZNF689 protein in liver cancer tissues is significantly related to tumor size ≥10 cm, tumor envelope infiltration, and microvascular infiltration, and may be a new predictor of the prognosis of liver cancer patients ( 27 ). In addition, knocking out ZNF689 can inhibit the proliferation and migration of liver cancer cells.…”

Section: Discussionmentioning

confidence: 99%

MiRNA-339 targets and regulates ZNF689 to inhibit the proliferation and invasion of gastric cancer cells

Jiang¹,

Liu²,

Hu³

et al. 2021

Transl Cancer Res TCR

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Background: Gastric cancer (GC) is the most common malignant tumor of the digestive system, and its mortality rate ranks first among malignant tumors. However, the pathogenesis of GC has not yet been fully elucidated. This study found that microRNA (miRNA)-339 is abnormally expressed in GC tissues. However, the role and molecular mechanism of miRNA-339 in the occurrence and development of GC are still unclear. Methods: Fluorescence quantitative polymerase chain reaction (qPCR) was used to detect the expression level of miRNA-339 in GC tissues and adjacent tissues and analyze the correlation with the clinicopathological characteristics of GC patients. Cell counting kit-8 (CCK-8) and Transwell experiments detected the effect of overexpression of miRNA-339 on the proliferation, invasion, and migration of GC cells. The luciferase reporter gene detected the downstream target molecules regulated by miRNA-339, and western blot was employed to detect the effect of overexpression of miRNA-339 on the expression of ZNF689.Results: The results of fluorescence qPCR showed that miRNA-339 was less expressed in GC tissues compared with adjacent tissues, and it was correlated with the patient's clinical tumor, node, metastasis (TNM) grade and lymph node metastasis. Cell function experiments showed that overexpression of miRNA-339 can significantly inhibit the proliferation, invasion, and migration of GC cells. The luciferase reporter gene showed that miRNA-339 can bind to the 3'-UTR region of ZNF689, and overexpression of miRNA-339 can significantly inhibit the expression of ZNF689 in GC cells. Overexpression of ZNF689 can significantly block the ability of overexpression of miRNA-339 to inhibit the proliferation and migration of GC cells.Conclusions: miRNA-339 inhibits the proliferation and invasion of GC cells through targeted regulation of the expression of ZNF689. In addition, the expression level of miRNA-339 can be used as a biomarker for the prognosis of GC.

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Positive expression of ZNF689 indicates poor prognosis of hepatocellular carcinoma

Cited by 10 publications

References 30 publications

Structures and biological functions of zinc finger proteins and their roles in hepatocellular carcinoma

Structures and biological functions of zinc finger proteins and their roles in hepatocellular carcinoma

Low Levels of TRIM28-Interacting KRAB-ZNF Genes Associate with Cancer Stemness and Predict Poor Prognosis of Kidney Renal Clear Cell Carcinoma Patients

MiRNA-339 targets and regulates ZNF689 to inhibit the proliferation and invasion of gastric cancer cells

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