Positive neuropathic sensory symptoms as endpoints in diabetic neuropathy trials

Apfel, Stuart C.; Asbury, A. K.; Bril, Vera; Bruns, Tony; Campbell, J. N.; Chalk, Colin; Dyck, Peter James; Feldman, Eva L.; Fields, Hannah; Grant, Ian; Griffin, John W.; Klein, Christopher J.; Lindblom, Ulf; Litchy, William J.; Low, P. A.; Melanson, Michel; Mendell, J. R.; Merren, M. D.; O’Brien, Peter C.; Rendell, Marc; Rizza, Robert A.; Thomas, P. K.; Walk, David; Wang, A. K.; Wessel, Klaus; Windebank, Anthony J.; Ziegler, Dan; Zochodne, Douglas W.

doi:10.1016/s0022-510x(01)00584-6

Cited by 85 publications

(19 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Volunteered or elicited symptoms and signs and other clinical neurophysiologic abnormalities are also needed to characterize the symptoms, signs, and overall severity of the polyneuropathy. Recent studies emphasize the importance of the proficiency of the clinical neurologic assessment (13,14). Atypical DPNs have been less well characterized and studied.…”

Section: Classification and Definition Of Diabetic Neuropathiesmentioning

confidence: 99%

“…When NC values have not been assessed, it is not possible to provide a confirmed diagnosis of DSPN—only a possible or probable diagnosis. Since the severity of DSPN is a combination of neuropathy symptoms, signs, neurophysiologic test abnormalities, and other dysfunctions and impairments, the sum scores of various measures of neurologic signs, symptoms, neurophysiologic test abnormalities, or scores of function of activities of daily living may provide an indication of the severity (13). …”

Section: Classification and Definition Of Diabetic Neuropathiesmentioning

confidence: 99%

“…The symptoms are distal, symmetrical, often associated with nocturnal exacerbations, and commonly described as prickling, deep aching, sharp, like an electric shock, and burning (13) with hyperalgesia and frequently allodynia upon examination (17). The symptoms are usually associated with the clinical signs of peripheral neuropathy, although occasionally in acute painful DPN, the symptoms may occur in the absence of signs.…”

Section: Painful Dpnmentioning

confidence: 99%

See 2 more Smart Citations

Diabetic Neuropathies: Update on Definitions, Diagnostic Criteria, Estimation of Severity, and Treatments

et al. 2010

View full text Add to dashboard Cite

Preceding the joint meeting of the 19th annual Diabetic Neuropathy Study Group of the European Association for the Study of Diabetes (NEURODIAB) and the 8th International Symposium on Diabetic Neuropathy in Toronto, Canada, 13–18 October 2009, expert panels were convened to provide updates on classification, definitions, diagnostic criteria, and treatments of diabetic peripheral neuropathies (DPNs), autonomic neuropathy, painful DPNs, and structural alterations in DPNs.

show abstract

Section: Classification and Definition Of Diabetic Neuropathiesmentioning

confidence: 99%

Section: Classification and Definition Of Diabetic Neuropathiesmentioning

confidence: 99%

Section: Painful Dpnmentioning

confidence: 99%

See 1 more Smart Citation

Diabetic Neuropathies: Update on Definitions, Diagnostic Criteria, Estimation of Severity, and Treatments

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Paresthesias and hyperesthesias are frequent. Patients often describe symptoms as prickling, deep aching, sharp, and burning [13]. …”

Section: Distal Symmetric Polyneuropathymentioning

confidence: 99%

“…Acute sensory neuropathy (ASN) is a variant of DSPN [13]. Many of the symptoms of ASN and DSPN are similar, but there are important differences in the onset, signs, and prognosis [14].…”

Section: Distal Symmetric Polyneuropathymentioning

confidence: 99%

State of the art papers Advances in the diagnosis and management of diabetic distal symmetric polyneuropathy

Kasznicki¹

2014

aoms

View full text Add to dashboard Cite

Distal symmetric polyneuropathy (DSPN) is the most common chronic complication of diabetes mellitus. The pathogenesis of DSPN is not fully elucidated, but it is certainly multifactorial in nature and attributable to metabolic and microvessel disorders related to chronic hyperglycemia, diabetes duration, and several cardiovascular risk factors. Early diagnosis and appropriate management are extremely important, since up to 50% of DSPN cases may be asymptomatic, and patients are unaware of foot injury leading to foot ulcers and amputation. Simple, validated tests such as the Neuropathy Disability Score and/or Vibration Perception Threshold may be used to diagnose DSPN. Similarly, neurological dysfunction screening questionnaires should be used to assess the quality and severity of DSPN symptoms. Using both methods enables prediction of the prognosis of diabetic patients with DSPN. No causative treatment of DSPN is known, but the results of clinical trials indicate that several treatment options are highly effective in symptomatic treatment of painful DSPN. The appropriate treatment of DSPN may improve the outcome, preventing or delaying the development of numerous diabetic complications.

show abstract

Small-Diameter Nerve Fiber Neuropathy in Systemic Lupus Erythematosus

Gøransson

Tjensvoll²,

Herigstad³

et al. 2006

Arch Neurol

View full text Add to dashboard Cite

show abstract

Positive neuropathic sensory symptoms as endpoints in diabetic neuropathy trials

Cited by 85 publications

References 0 publications

Diabetic Neuropathies: Update on Definitions, Diagnostic Criteria, Estimation of Severity, and Treatments

Diabetic Neuropathies: Update on Definitions, Diagnostic Criteria, Estimation of Severity, and Treatments

State of the art papers Advances in the diagnosis and management of diabetic distal symmetric polyneuropathy

Small-Diameter Nerve Fiber Neuropathy in Systemic Lupus Erythematosus

Contact Info

Product

Resources

About