Positive screening and carrier results for the England-wide universal newborn sickle cell screening programme by ethnicity and area for 2005–07

Streetly, Allison; Latinovic, Radoslav; Henthorn, Joan

doi:10.1136/jcp.2010.077560

Cited by 58 publications

(41 citation statements)

References 7 publications

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“…17 Microvascular obstruction by the sickled red blood cells result in tissue ischaemia and infarction. This, in combination with impaired immune function and splenic dysfunction, leads to an increased risk of osteomyelitis, with Salmonella the most common causative organism.…”

Section: Who Gets Osteomyelitis and Why Is It Important?mentioning

confidence: 99%

Acute haematogenous osteomyelitis in children

Yeo

Ramachandran

2014

BMJ

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Section: Who Gets Osteomyelitis and Why Is It Important?mentioning

confidence: 99%

Acute haematogenous osteomyelitis in children

Yeo

Ramachandran

2014

BMJ

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“…This is comparable with the rates reported from screening programs in other countries with large immigrant populations from the Caribbean and West Africa. 14,15 The incidence of SCD among NYS births to foreign-born non-Hispanic black mothers varies by country of origin: 1 in 65–70 infants born to mothers from Ghana or Nigeria and 1 in 180–190 infants born to mothers from Jamaica or Haiti. These estimates are consistent with data from maternal countries of origin.…”

Section: Discussionmentioning

confidence: 99%

Sickle cell disease incidence among newborns in New York State by maternal race/ethnicity and nativity

Wang

Kennedy

Casini

et al. 2013

Genetics in Medicine

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Purpose Sickle cell disease is estimated to occur in 1:300–400 African-American births, with higher rates among immigrants from Africa and the Caribbean, and is less common among Hispanic births. This study determined sickle cell disease incidence among New York State newborns stratified by maternal race/ethnicity and nativity. Methods Newborns with confirmed sickle cell disease born to New York State residents were identified by the New York State newborn screening program for the years 2000–2008 and matched to birth records to obtain birth and maternal information. Annual incidence rates were computed and bivariate analyses were conducted to examine associations with maternal race/ethnicity and nativity. Results From 2000 to 2008, 1,911 New York State newborns were diagnosed with sickle cell disease and matched to the birth certificate files. One in every 1,146 live births was diagnosed with sickle cell disease. Newborns of non-Hispanic black mothers accounted for 86% of sickle cell disease cases whereas newborns of Hispanic mothers accounted for 12% of cases. The estimated incidence was 1:230 live births for non-Hispanic black mothers, 1:2,320 births for Hispanic mothers, and 1:41,647 births for non-Hispanic white mothers. Newborns of foreign-born non-Hispanic black mothers had a twofold higher incidence of sickle cell disease than those born to US-born non-Hispanic black mothers (P < 0.001). Conclusion This study provides the first US estimates of sickle cell disease incidence by maternal nativity. Women born outside the United States account for the majority of children with sickle cell disease born in New York State. Such findings identify at-risk populations and inform outreach activities that promote ongoing, high-quality medical management to affected children.

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“…Neonatal blood spot screening is performed on all births in England, and sickle screening has become a part of this programme. The review by Streetly et al 5 on the screening programme results from 2005 to 2007 show the high incidence of these diseases particularly in the South East. The antenatal screening programme is universal in high-prevalence areas and selective in the lower prevalence areas.…”

Section: Discussionmentioning

confidence: 99%