Positive skin reaction test in haemodialysis patients allergic to nafamostat mesilate.

Okada, Hirokazu; Moriwaki, Kaname; Nakamoto, Hirotaka; Sugahara, Souichi; Suzuki, H

doi:10.1093/oxfordjournals.ndt.a027907

Cited by 9 publications

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“…In anti‐NM IgE‐positive patients in particular, this was 29.17 ± 10.74 (range, 23–51), although the timing of production of anti‐NM IgE was still unclear in our retrospective study. In several past reports about adverse effects that seemed to be induced by NM in hemodialysis or hemofiltration (9–12), adverse effects occurred within the first 1–10 administration sessions. This difference between our results and past reports might be due to our administration of adrenocortical steroid, SASP and 5‐ASA as concurrent treatments to LCAP.…”

Section: Discussionmentioning

confidence: 99%

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Detection of Specific IgE Antibodies to Nafamostat Mesilate as an Indication of Possible Adverse Effects of Leukocytapheresis using Nafamostat Mesilate as Anticoagulant

et al. 2004

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The aim was to determine whether adverse effects of leukocytapheresis (LCAP) are related to nafamostat mesilate (NM) as an anticoagulant. Anti-NM IgE were detected in inflammatory bowel disease (IBD) patients who were administrated LCAP in our institute. Forty-nine patients (ulcerative colitis (UC)/Crohn's disease (CD): 30/19) were evaluated. Anti-NM IgE was measured by the ELISA method. Total IgE level and eosinophil count was tested concurrently. We retrospectively checked the presence of allergic symptoms and medications used concurrently with LCAP. Anti-NM IgE were present in six symptomatic patients (6/49; 12.2%) whose adverse effects were highly suspected to be from NM. However, 21 patients showed anti NM IgE-negative, in spite of the fact that their adverse effects were also highly suspected to be from NM. Through the detection of anti-NM IgE alone we could not estimate the relevance of NM as an anticoagulant to the adverse effects of LCAP.

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Section: Discussionmentioning

confidence: 99%

“…Because of this fact, we suspected NM was somehow relevant to adverse effects of LCAP. Several past reports about adverse effects of hemodialysis or hemofiltration (9)(10)(11)(12) seem to support this possibility.…”

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confidence: 97%