Positron Emission Tomography Imaging of Tumor Cell Metabolism and Application to Therapy Response Monitoring

Challapalli, Amarnath; Aboagye, Eric O.

doi:10.3389/fonc.2016.00044

Cited by 52 publications

(33 citation statements)

References 170 publications

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“…This inherent flexibility and redundancy presents challenges for targeting amino acid metabolism, and therefore selection of patient groups, consideration of resistance mechanisms and identification of drug synergies will be crucially important for developing successful therapies. Techniques to image metabolism in vivo will also be valuable for identifying the tumors most likely to respond to treatment [8]. Below, we describe strategies for targeting amino acid metabolism, with a focus on glutamine and serine – the most rapidly consumed nutrients after glucose by many cultured cancer cell lines [4,5].…”

Section: Cancer Cell Amino Acid Metabolismmentioning

confidence: 99%

Targeting amino acid metabolism for cancer therapy

Lukey

Katt

Cerione

2017

Drug Discovery Today

245

174

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To support sustained biomass accumulation, tumor cells undergo metabolic reprogramming. Nutrient transporters and metabolic enzymes are regulated by the same oncogenic signals that drive cell-cycle progression. Some of the earliest cancer therapies used antimetabolites to disrupt tumor metabolism, and there is now renewed interest in developing drugs that target metabolic dependencies. Many cancers exhibit increased demand for specific amino acids, and become dependent on either an exogenous supply or upregulated de novo synthesis. Strategies to exploit such ‘metabolic addictions’ include depleting amino acids in blood serum, blocking uptake by transporters and inhibiting biosynthetic or catabolic enzymes. Recent findings highlight the importance of using appropriate model systems and identifying target patient groups as potential therapies advance into the clinic.

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Section: Cancer Cell Amino Acid Metabolismmentioning

confidence: 99%

Targeting amino acid metabolism for cancer therapy

Lukey

Katt

Cerione

2017

Drug Discovery Today

245

174

View full text Add to dashboard Cite

show abstract

“…One challenge facing choline PET is the discrepancy between labeled choline tracer uptake and steady‐state metabolites observed using MRS . This could be due to intrinsic differences between choline transport and phosphorylation that manifest as differences in tracer uptake relative to steady‐state levels, but it could also be due to alternative pathways such as metabolism of the choline tracers in other organs such as the liver …”

Section: Imaging Metabolic Lipid Changesmentioning

confidence: 99%

Imaging of cancer lipid metabolism in response to therapy

et al. 2019

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Lipids represent a diverse array of molecules essential to the cell's structure, defense, energy, and communication. Lipid metabolism can often become dysregulated during tumor development. During cancer therapy, targeted inhibition of cell proliferation can likewise cause widespread and drastic changes in lipid composition. Molecular imaging techniques have been developed to monitor altered lipid profiles as a biomarker for cancer diagnosis and treatment response. For decades, MRS has been the dominant non-invasive technique for studying lipid metabolite levels. Recent insights into the oncogenic transformations driving changes in lipid metabolism haverevealed new mechanisms and signaling molecules that can be exploited using optical imaging, mass spectrometry imaging, and positron emission tomography. These novel imaging modalities have provided researchers with a diverse toolbox to examine changes in lipids in response to a wide array of anticancer strategies including chemotherapy, radiation therapy, signal transduction inhibitors, gene therapy, immunotherapy, or a combination of these strategies. The understanding of lipid metabolism in response to cancer therapy continues to evolve as each therapeutic method emerges, and this review seeks to summarize the current field and areas of unmet needs.

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“…In addition, new technologies, especially in related with glycome and proteomics, immuno-histological tools and HPLC-MS can provide detailed biomedical information about small changes of sias in tumors. It might give birth to new round of remarkable and innovative therapeutic Imaging technology such as positron emission tomography (PET) [34,35] is playing critical roles in biomedical studies. Imaging techniques are commonly non-invasive diagnostic tools.…”

Section: Bioinformatics and Metabolomicsmentioning

confidence: 99%

Antimetastatic therapy at aberrant sialylation in cancer cells, a potential hotspot

Lu¹,

Lu²,

Xu³

et al. 2017

Clin Proteom Bioinform

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Neoplasm metastases involve a fixed cascade of pathological processes responsible for 90% cancer mortality worldwide. However, currently neoplasm metastases are poorly managed in humans for lack of good drug targets. To change this situation, new drug targets must be established. Aberrantly tumor sialylated study is one of potential drug targets, which has been involved for a half century. Many new discoveries show promising outcomes in experimental models. Since neoplasm tissues often contain higher levels of total sialic acids (sia), sialic acids-containing antigens, several types of sialic acid analogue, such as N-glycolylneuraminic acids, growing attentions of sia-related tumor diagnostics and therapeutics are needed to work with new cancer treatment approaches. Previously some compounds that inhibit pathologic pathways of sialic acids in tumor movements in vitro and tumor metastasis in animal tumor models were found. This type of pharmacological limitations of cancer metastasis treatments can be possibly solved by future glycome/metabolomics technology utilities. As the "central dogma" of glycobiology is still unknown to us, some fundamental questions related to carbohydrate itself are even more important comparing with individual experimental discoveries. In addition, mathematicor physics-majored talents in this topic might catalyze these new discoveries. In this review, we document these strings of lab biologic evidence, drug development updating and close relationships between cancer pathological profiles and therapeutic targets/benefits in clinics.

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Positron Emission Tomography Imaging of Tumor Cell Metabolism and Application to Therapy Response Monitoring

Cited by 52 publications

References 170 publications

Targeting amino acid metabolism for cancer therapy

Targeting amino acid metabolism for cancer therapy

Imaging of cancer lipid metabolism in response to therapy

Antimetastatic therapy at aberrant sialylation in cancer cells, a potential hotspot

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