Positron emission tomography in vascular dementia

Reuck, Jacques De; Decoo, D; Marchau, M.; Santens, Patrick; Lemahieu, Ignace; Strijckmans, Karel

doi:10.1016/s0022-510x(97)00213-x

Cited by 56 publications

(46 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with severe WMSH (i.e., Binswanger type vascular dementia) may be at particular risk for subclinical ischemia. Deficient autoregulatory reserve 43 and increased oxygen extraction fraction [44][45][46] have been demonstrated in this subgroup of SIVD. Thus, WMSH may be a marker for the severity of deep cerebral hypoperfusion.…”

Section: Discussionmentioning

confidence: 82%

“…30 From within the frontal, parietal, occipital, temporal, and limbic areas of the brain, we defined 16 cortical regions of interest (ROI) by their corresponding Brodmann areas. These regions (and the Brodmann areas they encompass) were the orbital frontal and frontal pole (10,11), lateral frontal (45,46,47), posterior frontal (6,8,44), superior frontal (8,9), primary motor (4), primary sensory (1, 2, 3), lateral parietal (39,40), mesial parietal (5,7,23,31), anterior occipital (37), visual association (17,18,19), anterior temporal (21,38), superior temporal (34,41,42), inferior temporal (20), and the limbic lobe (24,29). The method of transformation of each subject's T1-weighted image to the Talairach coordinate system involved several steps.…”

Section: Regional Analysis Using the Talairach Coordinate Systemmentioning

confidence: 99%

See 1 more Smart Citation

Hippocampal and cortical atrophy predict dementia in subcortical ischemic vascular disease

et al. 2000

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 82%

Section: Regional Analysis Using the Talairach Coordinate Systemmentioning

confidence: 99%

Hippocampal and cortical atrophy predict dementia in subcortical ischemic vascular disease

et al. 2000

View full text Add to dashboard Cite

show abstract

“…49 The PET pattern suggests a state of misery perfusion not only in the deep structures but also in the whole cerebral cortex. 50 Kandiah N, wiryasaputra l, Narasimhalu K, et al, Frontal subcortical ischemia is crucial for post stroke cognitive cerebral blood flow and oxygen consumption are more decreased in non-demented patients with leukoaraiosis and late-onset seizures compared to a normal age-matched control group, to a group of late-onset seizures without leukoaraiosis and to a group of mentally normal persons with leukoaraiosis.…”

Section: Brain Metabolismmentioning

confidence: 99%

Cognitive Impairment and Seizures in Patients with Lacunar Strokes

Reuck¹

2012

European Neurological Review

View full text Add to dashboard Cite

Abstractlacunar strokes are mainly related to cerebral microangiopathy and to the presence of leukoaraiosis. cognitive impairment is frequently linked to the presence of lacunes and white matter changes. The cognitive impairment consists mainly of disturbances of executive functions sometimes leading to dementia. it is mainly due to interruption of the frontal-subcortical neuronal circuits. Seizures are also observed in patients with lacunes and white matter changes. although lacunes cannot be considered as the cause of the seizures, there is a relationship between the occurrence of cognitive impairment and seizures. Repeated seizures promote further cognitive decline. however, the development of dementia in patients with late-onset epilepsy is most probably not directly due to the lacunes but rather due to alzheimer's disease or to cortical cerebrovascular lesions. The development of lacunes should only be the aggravating factor for the cognitive decline as demonstrated in the Nun study. Seizures have also been described to occur in patients with lacunar strokes and white matter changes. 11 however, the relationship between seizures and lacunar infarcts is uncertain. Keywords 12 EpidemiologySilent thalamic and basal ganglia lacunes observed on computed tomography (cT) or MRi of the brain are independent predictors of cognitive decline in elderly individuals without concomitant dementing processes such as alzheimer's disease. 13 The presence of lacunes in the thalamus is associated with lower scores of Mini Mental State Examination (MMSE) and worse compound scores for speed and motor control and executive functions.14 The overall prevalence of cognitive impairment 3 months after any kind of stroke and at annual follow-up remains relatively unchanged at 22 %.The prevalence ratio of cognitive impairment increases with older age (2 % for each year of age), ethnicity (2.2-fold higher among black people) and socioeconomic status (42 % increased among manual workers).The effect of education on the cognitive reserve is most pronounced in patients with mild and moderate degrees of brain pathology, whereas there is no influence in patients with severe MRi changes. 15 a progressive trend of cognitive impairment is observed among patients with smallvessel occlusion and lacunar infarction, with an average annual percentage change of 10 and 2 % respectively, up to 5 years after stroke. Parkinsonism can also be found associated by the presence of more severe ischaemic lesions in the striatum, interrupting the basal ganglia-thalamic-cortical 'motor' circuits.

show abstract

“…White matter hyperintensity on MR imaging and lacunar infarction may contribute to reduction in cerebral blood flow and glucose metabolism (DeCarli et al, 1996;Miyazawa et al, 1997). Several studies tried to identify distinctive patterns for vascular dementia on FDG-PET, but due to the limitations of the visual method on FDG-PET, no definitive finding could be obtained (De Reuck et al, 1998;Mielke et al, 1994;Sultzer et al, 1995). However, analysis using SPM and 3-D SSP could detect more precise and subtle differences between AD and vascular dementia.…”

Section: Vascular Dementiamentioning

confidence: 99%