Possibilities and impossibilities of magnetic nanoparticle use in the control of infectious biofilms

Quan, Kecheng; Zhang, Zexin; Ren, Yijin; Busscher, Henk J.; Mei, Henny C. van der; Peterson, Brandon W.

doi:10.1016/j.jmst.2020.08.031

Cited by 24 publications

(13 citation statements)

References 75 publications

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“…Nanotechnology is increasingly being developed as one of the novel strategies in the field of biomedicine. − Nanomaterials have unique advantages in antibacterial applications over other materials owing to their ultra-small size, large surface area-to-mass ratio, high reactivity, and enriched multifunction integration. − Particularly, magnetic nanoparticles (MNPs), approved by the U.S. Food and Drug Administration (FDA), have achieved great prominence in the antimicrobial therapy owing to their small size and high magnetism, immunoregulatory activity, feasible large-scale production, cell membrane penetrability, biocompatibility, and flexible surface functionalization. − For instance, MNPs have been used to combat the bacterial infections, such as Escherichia coli, Staphylococcus aureus [specifically Methicillin-resistant Staphylococcus Aureus (MRSA)], Salmonella enteritidis, and so forth, which have been applied to wound, blood, skin, and orthopedic and liver diseases. − However, MNPs were not effective in removing biofilms. , …”

Section: Introductionmentioning

confidence: 99%

Enhanced Eradication of Bacterial/Fungi Biofilms by Glucose Oxidase-Modified Magnetic Nanoparticles as a Potential Treatment for Persistent Endodontic Infections

Han

Ding

et al. 2021

ACS Appl. Mater. Interfaces

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Bacterial/fungal biofilm-mediated persistent endodontic infections (PEIs) are one of the most frequent clinical lesions in the oral cavity, resulting in apical periodontitis and tooth damage caused by loss of minerals. The conventional root canal disinfectants are poorly bio-safe and harmful to teeth and tissues, making them ineffective in treating PEIs. The development of nanomaterials is emerging as a promising strategy to eradicate disease-related bacteria/fungi. Herein, glucose oxidase (GOx)-modified magnetic nanoparticles (MNPs) were synthesized via a facile and versatile route for investigating their effects on removing PEI-related bacterial/fungal biofilms. It is found that GOx was successfully immobilized on the MNPs by detecting the changes in the diameter, chemical functional group, charge, and magnetic response. Further, we demonstrate that GOx-modified MNPs (GMNPs) exhibit highly effective antibacterial activity against Enterococcus faecalis and Candida albicans. Moreover, the antibacterial/fungal activity of GMNPs is greatly dependent on their concentrations. Importantly, when placed in contact with bacterial/fungal biofilms, the dense biofilm matrix is destructed due to the movement of GMNPs induced by the magnetic field, the formation of reactive oxygen species, and nutrient starvation induced by GOx. Also, the in vitro experiment shows that the as-prepared GMNPs have excellent cytocompatibility and blood compatibility. Thus, GMNPs offer a novel strategy to treat bacteria/fungi-associated PEIs for potential clinical applications.

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Section: Introductionmentioning

confidence: 99%

Enhanced Eradication of Bacterial/Fungi Biofilms by Glucose Oxidase-Modified Magnetic Nanoparticles as a Potential Treatment for Persistent Endodontic Infections

Han

Ding

et al. 2021

ACS Appl. Mater. Interfaces

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“…Targeting NIR irradiation to an infection site requires extremely precise dosing of photothermal nanoparticles to prevent collateral tissue damage [13] as the heat generated spreads through adjacent tissue. Magnetic targeting of photothermal nanoparticles to an infection site has also been suggested [27][28][29], but the current state of clinically applied magnetic targeting instrumentation impedes targeting to micron-sized infectious biofilms [30].…”

Section: Discussionmentioning

confidence: 99%

Encapsulation of Photothermal Nanoparticles in Stealth and pH-Responsive Micelles for Eradication of Infectious Biofilms In Vitro and In Vivo

Gao

et al. 2021

Nanomaterials

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Photothermal nanoparticles can be used for non-antibiotic-based eradication of infectious biofilms, but this may cause collateral damage to tissue surrounding an infection site. In order to prevent collateral tissue damage, we encapsulated photothermal polydopamine-nanoparticles (PDA-NPs) in mixed shell polymeric micelles, composed of stealth polyethylene glycol (PEG) and pH-sensitive poly(β-amino ester) (PAE). To achieve encapsulation, PDA-NPs were made hydrophobic by electrostatic binding of indocyanine green (ICG). Coupling of ICG enhanced the photothermal conversion efficacy of PDA-NPs from 33% to 47%. Photothermal conversion was not affected by micellar encapsulation. No cytotoxicity or hemolytic effects of PEG-PAE encapsulated PDA-ICG-NPs were observed. PEG-PAE encapsulated PDA-ICG-NPs showed good penetration and accumulation in a Staphylococcus aureus biofilm. Penetration and accumulation were absent when nanoparticles were encapsulated in PEG-micelles without a pH-responsive moiety. PDA-ICG-NPs encapsulated in PEG-PAE-micelles found their way through the blood circulation to a sub-cutaneous infection site after tail-vein injection in mice, yielding faster eradication of infections upon near-infrared (NIR) irradiation than could be achieved after encapsulation in PEG-micelles. Moreover, staphylococcal counts in surrounding tissue were reduced facilitating faster wound healing. Thus, the combined effect of targeting and localized NIR irradiation prevented collateral tissue damage while eradicating an infectious biofilm.

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“…This finding indicates that magnetic targeting is a promising strategy for the treatment of drug‐resistant biofilm infections. However, in vivo magnetic targeting relies on sophisticated techniques, and the current magnetic‐targeting techniques are insufficient to precisely target microscale infectious biofilms, and the clinical translation of the use of MNPs is still difficult (Quan, Zhang, et al, 2021).…”

Section: Advantages Of Nanocarriers For Combating Biofilmsmentioning

confidence: 99%

Nanocarriers for combating biofilms: Advantages and challenges

Zhang

Lin

et al. 2022

Journal of Applied Microbiology

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Bacterial biofilms are highly resistant to antibiotics and pose a great threat to human and animal health. The control and removal of bacterial biofilms have become an important topic in the field of bacterial infectious diseases. Nanocarriers show great anti-biofilm potential because of their small particle size and strong permeability.In this review, the advantages of nanocarriers for combating biofilms are analysed.Nanocarriers can act on all stages of bacterial biofilm formation and diffusion. They can improve the scavenging effect of biofilm by targeting biofilm, destroying extracellular polymeric substances and enhancing the biofilm permeability of antimicrobial substances. Nanocarriers can also improve the antibacterial ability of antimicrobial drugs against bacteria in biofilm by protecting the loaded drugs and controlling the release of antimicrobial substances. Additionally, we emphasize the challenges faced in using nanocarrier formulations and translating them from a preclinical level to a clinical setting.

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Possibilities and impossibilities of magnetic nanoparticle use in the control of infectious biofilms

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Cited by 24 publications

References 75 publications

Enhanced Eradication of Bacterial/Fungi Biofilms by Glucose Oxidase-Modified Magnetic Nanoparticles as a Potential Treatment for Persistent Endodontic Infections

Enhanced Eradication of Bacterial/Fungi Biofilms by Glucose Oxidase-Modified Magnetic Nanoparticles as a Potential Treatment for Persistent Endodontic Infections

Encapsulation of Photothermal Nanoparticles in Stealth and pH-Responsive Micelles for Eradication of Infectious Biofilms In Vitro and In Vivo

Nanocarriers for combating biofilms: Advantages and challenges

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