Possibilities for improvement of humoral innate immunity in turkeys and hens in conditions of thermal stress by the immunomodulator Immunobeta

Bozakova, N.; Sotirov, L.; Denev, S.; Koynarski, Tsvetoslav

doi:10.1101/305300

Cited by 2 publications

(2 citation statements)

References 16 publications

(14 reference statements)

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“…In a similar experiment, Bozakova et al (2020) explored the possibilities for improvement of humoral immunity via the application of Immunobeta® immunomodulator among turkeys and hens.…”

Section: Discussionmentioning

confidence: 99%

Influence of the Immunomodulator AVIGEN to Broiler Chicken Humoral Immune Factors

Petrova-Tsenin¹

2021

IJIAAR

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The nonspecific immune response plays an important role in organism's defense against a variety of pathogens. Two major factors in this process are blood serum lysozyme and alternative pathway of complement activation (APCA). Over the past few decades, the application of various substances, targeting improved levels of natural immunity have become part of the mainstream trends in livestock rearing programs. The current study examined the influence of the polybacterial immunomodulator AVIGEN on the performance of the aforementioned immune factors among broiler chicken hybrids. The experimental group demonstrated better overall performance for both parameters of interest. APCA activity for the treated group (549.10±19.69 CH50) was significantly higher compared to the result obtained for the controls (377.40±9.58 CH50), (P<0.001). Results for the other parameter were even more indicative. The measured concentration of the serum lysozyme for the treated group was twice as high compared to the control birds -6.17±0.49 mg/L vs. 2.99±0.27 mg/L, respectively. Therefore, the introduction of the AVIGEN immunomodulator to animals' diet has strong potential to improve natural humoral immunity in poultry farming.

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“…In a similar experiment, Bozakova et al (2020) explored the possibilities for improvement of humoral immunity via the application of Immunobeta® immunomodulator among turkeys and hens.…”

Section: Discussionmentioning

confidence: 99%

Influence of the Immunomodulator AVIGEN to Broiler Chicken Humoral Immune Factors

Petrova-Tsenin¹

2021

IJIAAR

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“…Many authors have shown that lysozyme is able to improve immunoglobulin A secretion and activate macrophage with a rapid riddance of bacterial diseases (Wang et al, 2005;Clarke et al, 2010;Dang et al, 2022). Thus, lysozyme is a natural antimicrobial protein considered a necessary component of innate immunity (Liu et al, 2010;Bozakova et al, 2020;Bastamy et al, 2024). According to these data, antibiotics can be replaced by lysozymes in the diet of poultry.…”

Section: Introductionmentioning

confidence: 99%

Lysozyme as an alternative to antibiotics improves growth, antioxidants status, immunity, and intestinal bacteria in broiler chickens during the fattening period

El-Ratel,

EL-Deep,

Alharbi

et al. 2024

Arch. Anim. Breed.

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Abstract. The present study aimed to evaluate the impact of dietary lysozyme levels on the growth performance, hematological and blood biochemical parameters, immunity, antioxidant capacity, and intestinal microbial count in broiler chickens. Three-hundred 1 d old birds (Cobb-avian500) were used and divided into five groups (five replicates per group, 60 birds per replicate). Birds in the first group were fed a control diet, while birds in the second, third, fourth, and fifth groups were fed the control diet with 0.2 g lincomycin, 1 g commercial lysozyme, 25 mg chicken egg lysozyme, and 50 mg egg lysozyme per kg of diet, respectively. Results confirmed that, in comparison with the control diet, all supplements had greater impacts on final body weight and body weight gain, and only the egg lysozyme diet (50 mg kg−1 diet) increased feed intake. Lincomycin, commercial lysozyme, and egg lysozyme (25 mg) improved the feed conversion ratio (FCR). Birds fed commercial lysozyme and egg lysozymes showed significantly increased hemoglobin and red blood cell counts. All supplements reduced white blood cells, heterophils, and heterophils / lymphocytes ratio and increased lymphocytes. All supplements significantly increased serum total protein, albumin, globulin, and glucose. The diet of egg lysozyme (50 mg kg−1) significantly decreased alpha-globulin, alanine aminotransferase, triglycerides, cholesterol, and urea levels and increased high-density lipoproteins. Diets with lincomycin, commercial lysozyme, and egg lysozyme significantly increased antioxidant capacity and decreased malondialdehyde (MDA). The interferon-gamma (IFNγ) and interlukin-2 (IL-2) were significantly improved by lincomycin, commercial lysozyme and egg lysozyme diets, but interlukin-10 (IL-10) was significantly increased only by the egg lysozyme (50 mg kg−1) diet. The total bacterial count, Salmonella, Escherichia coli, and Proteus counts were significantly decreased. Dressing rate and breast weight percentage were significantly increased by the egg lysozyme (50 mg kg−1) diet. Thigh weight percentage was increased only by the commercial lysozyme diet. In conclusion, chicken egg lysozyme (50 mg kg−1), a promising alternative for antibiotics in broiler chickens' diet, can enhance growth performance, antioxidant status, immunity, and intestinal bacteria.

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Possibilities for improvement of humoral innate immunity in turkeys and hens in conditions of thermal stress by the immunomodulator Immunobeta

Cited by 2 publications

References 16 publications

Influence of the Immunomodulator AVIGEN to Broiler Chicken Humoral Immune Factors

Influence of the Immunomodulator AVIGEN to Broiler Chicken Humoral Immune Factors

Lysozyme as an alternative to antibiotics improves growth, antioxidants status, immunity, and intestinal bacteria in broiler chickens during the fattening period

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