Possibilities of using functional biologically active organosilicon compounds in veterinary practice

Abstract

Abstract. Purpose. Evaluation of the possibility of using silicon, silicon-zinc, silicon-zinc organoboron compounds and compositions based on them for the treatment and prevention of inflammatory and non-inflammatory diseases in agricultural and small domestic animals. Method. There was carried out a clinical trial of various medicinal compositions with a base in the form of organic compounds of silicon, zinc, boron, both containing antimicrobial components and environmentally friendly agents. For this purpose, groups of animals were formed on the principle of analogs. The multiplicity and administration of drugs depended on the studied pathology. Results. The obtained results showed a high efficiency of the studied compositions, in particular, in the treatment of postpartum diseases of the uterus of an inflammatory nature, the effectiveness of the application was 95.5 %, with conservative treatment of the retention of the placenta – 100 %. Also, these funds are highly effective for the treatment of hyperkeratosis of the udder nipples, without changing the technology of milking. On average, the effectiveness of the compositions reached 86.1 % when the funds were used for 7 days. The study of an antimicrobial composition based on organosilicon glycerohydrogel in the treatment of purulent-necrotic lesions in the distal part of the extremities in cows can reduce the frequency of procedures and the duration of treatment by 6 days compared to animals in the control group. Scientific novelty. New functional biologically active pharmacological agents based on silicon-, silicon-zinc-, silicon-zinc boron glycerohydrogels have been developed and clinically tested for the treatment of cows with postpartum uterine diseases, in particular, postpartum endometritis and retention of the placenta, hyperkeratosis of the udder nipples, purulent-necrotic diseases of the distal also necrotic skin lesions of small domestic animals.