Possibility of a patch system as a new oral delivery system

Eaimtrakarn, Sudarat; Prasad, Y. V. Rama; Puthli, Shivanand P.; Yoshikawa, Yukako; Shibata, Nobuhito; Takada, Kanji

doi:10.1016/s0378-5173(02)00534-3

Cited by 28 publications

(13 citation statements)

References 25 publications

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“…The bioavailability of FD 4 delivered via patch system, tablet or solution was evaluated by determining FD 4 concentration in plasma. As FD 4 is not absorbed via the transcellular route but the paracellular route in epithelium13 by reason of being a Class III drug with high solubility and low permeability, FD 4 is commonly used as a fluorescence marker in studies focusing on the delivery of therapeutic peptides/proteins 2. Permeability of FD 4 across rat intestinal mucosa is well known ( P app : 6.2 × 10 −6 cm/s) which means that 3–4% of the administered FD 4 permeates from the donor to the acceptor side 4, 14.…”

Section: Methodsmentioning

confidence: 99%

“…These include the release of the drug from the administered formulation and the changing conditions that the drug has to pass on its way to the target receptor 1. Therefore many efforts have been devoted in the past to develop drug delivery systems (DDS) that include several layers which perform different tasks including adhesion, controlled release and protection from the surroundings 2, 3. While all these approaches have been shown to improve the oral bioavailability of large molecules, none of them offers a complete solution for adequate and safe oral administration.…”

Section: Introductionmentioning

confidence: 99%

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Design and In Vivo Evaluation of a Patch System Based on Thiolated Polymers

Hoyer

Greindl

Bernkop‐Schnürch

2009

Journal of Pharmaceutical Sciences

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Design and In Vivo Evaluation of a Patch System Based on Thiolated Polymers

Hoyer

Greindl

Bernkop‐Schnürch

2009

Journal of Pharmaceutical Sciences

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“…Water insoluble ethylcellulose layer provides the protection against enzymatic hydrolysis 141 with a sustained release over a period of 6 h. The hypoglycemic effects by patches with carbapol was > 50% with doses in range of 5-10 U/Kg. Results state that Insulin absorption kinetics from patches depends on adhesion time and patch dissolution time, which indeed depends on the composition of the patch.…”

Section: Fig 9: Plasma Levels Of Diabetic Rats After Oral Administratmentioning

confidence: 99%

Untitled

2013

IJPSR

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The Present study focuses on the challenges facing the development of oral insulin the fact we have no formulation in market, being an attractive and advantageous over the regular injections. Physiological and biological factors of the insulin has great influence for the development of an oral formulation with many difficulties regarding the stability over gastric pH and proteolytic enzymes, selection of the proper formulation and its components depends on these conditions. The development with insulin therapy are needed with better patience compliance, low toxicity, higher glycemic control, thereby Diabetes related complications occurrence can be prevented. INTRODUCTION: In terms of efficacy, insulin in form of parental route is satisfactory, however it is associated with some severe adverse conditions like, peripheral hyperinsulinemia, smooth muscle cell proliferation, diabetic macro and micro angiopathy, lipoatrophy or lipohyertophy have become very common. Insulin delivery by oral route is not effective due to its susceptibility to enzymatic degradation in GI & Permeability across intestinal epithelium is low 1, 2. The proper combination of Multifunctional polymers will result a better biocompatible, biodegradable, hydrophilic and protective characteristic with better absorption orally in the GI 3 .

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“…This patch was tested in dog buccal mucosa and was shown to remain in place for up to 17 hours without any obvious discomfort. A similar three-layer patch was designed and tested on humans, resulting in a in situ placement for up to 15 h regardless of eating or drinking [131].…”

Section: Adhesive Patchesmentioning

confidence: 99%

Mucoadhesive Polymers for Oral Transmucosal Drug Delivery: A Review

Bagán¹,

Paderni²,

Termine³

et al. 2012

CPD

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Abstract:The oral mucosa offers an interesting site for the application of dosage forms that release drugs within/throughout the oral mucosa, by assuring a high drug bioavailability for topic and systemic effects. However, the relative permeability of the oral mucosa and the washing effect related to the oral fluids and mechanical stresses must be considered in the formulation of oral dosage forms. Since a sustained drug release can be guaranteed only if dosage forms remain in contact with the oral site of absorption/application for a prolonged time, the development of mucoadhesive dosage forms is mandatory. The mucoadhesion is a complex phenomenon and the mucoadhesive bond consists of two different parts, the mucoadhesive polymers and the mucous substrate. In addition to factors related to the oral mucosa and oral environment features, the physical-chemical characteristics of mucoadhesive polymers must be also considered as factors influencing the mucoadhesive bonds. While it is not possible to modify the mucosal features or it is possible to modify or inhibit only in part certain mucosal processes, the knowledge of polymer properties influencing mucoadhesive bonds allows to modify or to control these properties in developing increasingly effective mucoadhesive systems. The aims of this review are to discuss the several mechanisms and factors behind the phenomenon of mucoadhesion with particular reference to the features of the oral environment, oral mucosa, and polymeric compounds influencing mucoadhesion process. Finally, a brief mention to the main mucoadhesive dosage forms designed for oral transmucosal drug delivery is made.

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Possibility of a patch system as a new oral delivery system

Cited by 28 publications

References 25 publications

Design and In Vivo Evaluation of a Patch System Based on Thiolated Polymers

Design and In Vivo Evaluation of a Patch System Based on Thiolated Polymers

Untitled

Mucoadhesive Polymers for Oral Transmucosal Drug Delivery: A Review

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