Possibility of Interactions between Prescription Drugs and OTC Drugs-Interaction between Levodopa Preparation and Saclon, an OTC Drug for Upset Stomach-

Our series of studies aimed to examine the possibility of interactions between prescription drugs and over-the-counter (OTC) drugs by monitoring plasma drug concentrations in rats. When a levodopa preparation indicated for patients with Parkinson's disease was administered in combination with Takeda Kampo Ichoyaku K-matsu (A), Taisho Kampo Ichoyaku (B), or Kanebo Kampo Ichoyaku H(C), which are OTC kampo medicines for upset stomach, the plasma levodopa concentration-time curves were shifted downward and the AUC for levodopa was signiˆcantly lowered. These results indicate that there may be some interactions between the levodopa preparation and these OTC kampo medicines when ingested together, which leads to a reduction in the bioavailability of levodopa. On the other hand, concomitant administration of the levodopa preparation with Takeda Kampo Ichoyaku A-matsu (D) did not alter any of the pharmacokinetic parameters for levodopa. According to the package inserts for the OTC kampo medicines, A, B and C, but not D, contain metallic additives, such as aluminum silicate and magnesium stearate. In addition, combination with a kampo basis of D (Koshaheiisan-ka-shakuyaku) showed no detectable change in levodopa bioavailability. From these results, it was concluded that metallic additives may play an essential role in generating the drug-interaction between levodopa preparation and OTC kampo medicine for upset stomach.

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Possibility of Interactions between Prescription Drugs and OTC Drugs (2nd Report)-Interaction between Levodopa Preparation and OTC Kampo Medicines for Upset Stomach-

Sunagane

Aikawa

Ohta

et al. 2006

YAKUGAKU ZASSHI

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Establishment of a “Correct Use of Medicine” Educational Program for Health and Physical Education at Junior High Schools

ひとみ

2013

YAKUGAKU ZASSHI

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Under new courses of study, medicine-related content has been incorporated into health and physical education at junior high schools, and classes on the``Correct use of medicine'' began as part of this content in 2012. Based on thè`S chool Health and Safety Law'' implemented in April 2009, health guidance provided by school physicians, pharmacists, and dentists has also been incorporated. This has raised expectations that educational programs concerning thè`C orrect use of medicine'' could be eŠectively implemented through cooperation between school pharmacists and health and physical education teachers. In order to clarify current knowledge and awareness regarding the``Correct use of medicine'' among students, as well as the guidance provided at schools, we conducted a training workshop for teachers at elementary and junior high schools in Gifu City. Based on the results, we developed a``Correct use of medicine'' educational program. We then presented this program in a class with 40 third-year junior high school students on January 31, 2012. It consisted of an introduction (7 min), a development portion (35 min), and a conclusion (8 min). After the class, a question and answer session was held with observers (n＝11) and a questionnaire survey, which resulted in high evaluations, was conducted on the students. Comments including concern over the large volume of educational content and the need to raise awareness were heard, but the results of the questionnaire survey showed that many students found the class content useful and interesting.Key words-``Correct use of medicine'' educational program; school physician; student; health and physical education at junior high school

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Pharmacy Students' Participation in Medicinal Education for Children

et al. 2010

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Over recent years, use of self-medication by patients to help prevent and treat their own medical conditions has become increasingly widespread. However, despite provision of warnings and the taking of precautions, health hazards due to medication have occurred and continue to occur. In order to ward off such incidents, it is necessary for both children and adults to be educated about appropriate drug use. And, it is desirable that pharmacy students participate in this medicinal education as a means of a‹rming what they have learned and improving their communication skills at an early stage in their professional development. In 2008, we held medicinal education classes for pupils and parents at three elementary schools in Aichi Prefecture with the aim of promoting appropriate drug use. Each class comprised of two parts: an introductory lecture in quiz form, lasting about 30 minutes, and a 30-minute participatory group experiment. Subsequently, the activities carried out in both parts were evaluated across 6 items and 3 items respectively, and scored from Satisˆed to Unsatisˆed (4-step scale) by the pupils and their parents. We also conducted a questionnaire survey on this activity to the pharmacy students. We achieved successful results, gaining high Satisˆed levels (better than 90％) in all items. This activity beneˆted both the children and the pharmacy students. It not only provided education for the general public regarding the appropriate drug use, but is also helping to foster the development in Japan of well-trained future pharmacists.

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Possibility of Interactions between Prescription Drugs and OTC Drugs-Interaction between Levodopa Preparation and Saclon, an OTC Drug for Upset Stomach-

Cited by 4 publications

References 4 publications

Possibility of Interactions between Prescription Drugs and OTC Drugs (2nd Report)-Interaction between Levodopa Preparation and OTC Kampo Medicines for Upset Stomach-

Possibility of Interactions between Prescription Drugs and OTC Drugs (2nd Report)-Interaction between Levodopa Preparation and OTC Kampo Medicines for Upset Stomach-

Establishment of a “Correct Use of Medicine” Educational Program for Health and Physical Education at Junior High Schools

Pharmacy Students' Participation in Medicinal Education for Children

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