Possible antioxidant mechanism of coenzyme Q10 in diabetes: impact on Sirt1/Nrf2 signaling pathways

Samimi, Fatemeh; Baazm, Maryam; Eftekhar, Ebrahim; Rajabi, Sadegh; Goodarzi, Mohammad Taghi; Mashayekhi, Farideh Jalali

doi:10.4103/1735-5362.272561

Cited by 36 publications

(13 citation statements)

References 29 publications

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“…Nrf2, upon a redox status imbalance, dissociates from the sequestration complex and translocates to the nucleus where it interacts with the antioxidant-responsive element (ARE) of antioxidant genes. These events lead to the transcriptional activation of its target genes such as heme oxygenase-1, superoxide dismutase, glutathione peroxidase and glutathione S-transferase [ 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Moringa oleifera Leaf Extract Upregulates Nrf2/HO-1 Expression and Ameliorates Redox Status in C2C12 Skeletal Muscle Cells

et al. 2021

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Moringa oleifera is a multi-purpose herbal plant with numerous health benefits. In skeletal muscle cells, Moringa oleifera leaf extract (MOLE) acts by increasing the oxidative metabolism through the SIRT1-PPARα pathway. SIRT1, besides being a critical energy sensor, is involved in the activation related to redox homeostasis of transcription factors such as the nuclear factor erythroid 2-related factor (Nrf2). The aim of the present study was to evaluate in vitro the capacity of MOLE to influence the redox status in C2C12 myotubes through the modulation of the total antioxidant capacity (TAC), glutathione levels, Nrf2 and its target gene heme oxygenase-1 (HO-1) expression, as well as enzyme activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and transferase (GST). Moreover, the impact of MOLE supplementation on lipid peroxidation and oxidative damage (i.e., TBARS and protein carbonyls) was evaluated. Our results highlight for the first time that MOLE increased not only Nrf2 and HO-1 protein levels in a dose-dependent manner, but also improved glutathione redox homeostasis and the enzyme activities of CAT, SOD, GPx and GST. Therefore, it is intriguing to speculate that MOLE supplementation could represent a valuable nutrition for the health of skeletal muscles.

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Section: Introductionmentioning

confidence: 99%

Moringa oleifera Leaf Extract Upregulates Nrf2/HO-1 Expression and Ameliorates Redox Status in C2C12 Skeletal Muscle Cells

et al. 2021

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“…Liver-specific SIRT1 knockout mice with a standard diet presented increased systemic glucose levels, hepatic free fatty acid, and cholesterol content ( 10 ). It also raises Nrf2 expression in the liver cells and thereby enhances antioxidant power through increasing superoxide dismutase (SOD), and catalase (CAT) enzymes, and glutathione (GSH) content in the hepatocytes ( 11 ). According to the previous documents, SIRT1 and Nrf2 play a critical role in the NASH improvement ( 10 11 ).…”

Section: Introductionmentioning

confidence: 99%

“…It also raises Nrf2 expression in the liver cells and thereby enhances antioxidant power through increasing superoxide dismutase (SOD), and catalase (CAT) enzymes, and glutathione (GSH) content in the hepatocytes ( 11 ). According to the previous documents, SIRT1 and Nrf2 play a critical role in the NASH improvement ( 10 11 ). It has been reported that folic acid upregulates SIRT1 expression, then restores peroxisome proliferator-activated receptor alpha (PPARa) and attenuates NASH ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

Attenuating effects of allantoin on oxidative stress in a mouse model of nonalcoholic steatohepatitis

Hamidizad

Moslehi

Rastegarpanah

2021

Research in Pharmaceutical Sciences

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Background and purpose: Nonalcoholic steatohepatitis (NASH) is considered a common and serious liver disease, which develops into cirrhosis, fibrosis, and even hepatocellular carcinoma. Oxidative stress is identified as an important factor in the induction and promotion of NASH. Allantoin is a natural and safe compound and has notable effects on lipid metabolism, inflammation, and oxidative stress. Therefore, this study was aimed to assess the role of allantoin on the oxidative stress and SIRT1/Nrf2 pathway in a mouse model of NASH. Experimental approach: C57/BL6 male mice received saline and allantoin (saline as the control and allantoin as the positive control groups). NASH was induced by a methionine-choline deficient diet (MCD). In the NASH-allantoin (NASH-Alla) group, allantoin was injected for 4 weeks in the mice feeding on an MCD diet. Afterward, histopathological, serum, oxidative stress, and western blot evaluations were performed. Findings/Results: We found NASH provided hepatic lipid accumulation and inflammation. Superoxide dismutase (SOD) and glutathione (GSH) levels decreased, lipid peroxidation increased, and the expression of SIRT1 and Nrf2 downregulated. However, allantoin-treatment decreased serum cholesterol, ALT, and AST. Liver steatosis and inflammation were improved. Protein expression of SIRT1 and Nrf2 were upregulated and SOD, CAT, and GSH levels increased and lipid peroxidation decreased. Conclusion and implications: It seems that the antioxidant effects of allantoin might have resulted from the activation of SIRT1/Nrf2 pathway and increase of cellular antioxidant power.

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“…reported an increase in the activity of this enzyme in the eye lens of STZ-diabetic rats ( 27 ). However, it has been indicated that STZ significantly decreased SOD activity in the liver and serum of diabetic rats ( 28 29 ). On the other hand, Sadi et al .…”

Section: Discussionmentioning

confidence: 99%

Protective effects of a standardized extract of Iris germanica on pancreas and liver in streptozotocin-induced diabetic rats

Mahdinezhad

Hooshmand

Soukhtanloo

et al. 2021

Research in Pharmaceutical Sciences

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Background and purpose: Previous studies have shown the antioxidant, anti-inflammatory, immunomodulatory, and hypolipidemic activities of Iris germanica . The aim of the present study was to evaluate the protective effects of hydroalcoholic extract of Iris germanica rhizomes on streptozotocin-induced diabetic rats. Experimental approach: Twenty-four male Wistar rats were randomly assigned into four groups including a normal control group, diabetic control group, diabetic groups treated for 4 weeks with 100 and 200 mg/kg/day of the Iris germanica extract (IGE). Findings/Results: Induction of diabetes significantly decreased the body weight gain and considerably increased the serum levels of glucose, triglyceride, blood urea nitrogen (BUN), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). Diabetes also diminished the antioxidant capacity of the liver (decrease of thiol groups) and significantly degenerated pancreatic islands. The IGE at both doses of 100 and 200 mg/kg significantly reduced the levels of glucose, triglyceride, AST, ALT, and ALP. Moreover, IGE increased the total antioxidant capacity of the liver and ameliorated pancreatic island morphology. The extract had no significant effect on body weight and BUN level. Conclusion and implication: These findings suggest that Iris germanica rhizomes inhibits the progression of hyperglycemia and hypertriglyceridemia and has protective effects against diabetes-induced injury of the liver and pancreas. Therefore, this plant has the potential to be used as a natural product for controlling diabetes.

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Possible antioxidant mechanism of coenzyme Q10 in diabetes: impact on Sirt1/Nrf2 signaling pathways

Cited by 36 publications

References 29 publications

Moringa oleifera Leaf Extract Upregulates Nrf2/HO-1 Expression and Ameliorates Redox Status in C2C12 Skeletal Muscle Cells

Moringa oleifera Leaf Extract Upregulates Nrf2/HO-1 Expression and Ameliorates Redox Status in C2C12 Skeletal Muscle Cells

Attenuating effects of allantoin on oxidative stress in a mouse model of nonalcoholic steatohepatitis

Protective effects of a standardized extract of Iris germanica on pancreas and liver in streptozotocin-induced diabetic rats

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