Possible association between nickel and chromium and oral cancer: A case–control study in central Taiwan

Yuan, Tzu-Hsuen; Lian, Ie Bin; Tsai, Kuo-Yang; Chang, Tsun-Kuo; Chiang, Chi Ting; Su, Chin-Chuan; Hwang, Yaw-Huei

doi:10.1016/j.scitotenv.2010.11.038

Cited by 70 publications

(47 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover a high percentage of cases bearing elevated arsenic count may also focus on its effect in contributing to this malignancy. Contrary to our findings a recent case-control study in central Taiwan revealed the absence of significant association between As blood levels and oral malignant and premalignant lesions [20]. However previous studies, it was found positive associations between this metal and risk of various type of cancers [21][22][23][24].…”

Section: Resultscontrasting

confidence: 99%

Oral Carcinoma, HPV Infection, Arsenic Exposure-their Correlation in West Bengal, India

Pal¹,

Raychowdhury²,

Halder³

2016

Otolaryngol (Sunnyvale)

View full text Add to dashboard Cite

Objective: The aim is to find out any possible correlation between HPV infection and oral carcinoma along with this metal toxicity. Methods:Ethical clearance for this study was obtained from the Ethics Committee of Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan. Patients attending our hospital were screened for the presence of oral premalignant and malignant lesions. The subjects were administered a standard questionnaire. The buccal swab and hair samples (107 cases and 50 controls) were collected after obtaining informed consent from all the corresponding subjects, and were analysed for detection of HPV 16 DNA and arsenic level analysis, respectively.Results: 22.5% of malignant samples showed the presence of HPV 16 DNA. 80% of cases showed their arsenic count above the safe limit (0.8 µg/g). Conclusion:A considerable percentage of malignant samples showed the presence of HPV16 DNA, indicating that there may be a correlation between HPV infection and oral malignancy in this population. A higher percentage of cases showing an elevated arsenic count states a possible link between arsenic toxicity and the development of this disease. However, a higher population size and statistical analysis are required for a proper conclusion.

show abstract

Section: Resultscontrasting

confidence: 99%

Oral Carcinoma, HPV Infection, Arsenic Exposure-their Correlation in West Bengal, India

Pal¹,

Raychowdhury²,

Halder³

2016

Otolaryngol (Sunnyvale)

View full text Add to dashboard Cite

show abstract

“…In this study, the difference of micronuclei and apoptosis frequency between cases and controls is also found to be significant. On the contrary to our findings, a recent study in central Taiwan revealed the absence of significant association between As blood levels and oral malignant and premalignant lesions [14]. However, previous studies [15][16][17][18] found positive associations between this metal and risk of various types of cancers.…”

Section: Discussioncontrasting

confidence: 99%

Study of arsenic exposure in oral/oropharyngeal carcinoma in West Bengal

Pal

Raychowdhury

Dolai

et al. 2017

Int J Occup Med Environ Health

View full text Add to dashboard Cite

Objectives:To study any possible correlation between arsenic toxicity and the development of oral carcinoma in West Bengal population. Material and Methods: Ethical clearance for this study was obtained from the Vivekananda Institute of Medical Sciences. Out of 30 785 patients attending our hospital from November 2012 to July 2015, 107 cases and 50 control individuals were selected. The hair and buccal smear samples were obtained upon their consent for the purpose of the analysis of arsenic count and cytogenetic damage, respectively. Results: Ninety-six percent of cases came from the highly arsenic affected districts and 81.3% showed their arsenic count above the safe limit (0.8 μg/g) whereas 96% of the controls' arsenic count was within the safe limit. The study showed a significant difference of the micronuclei and apoptosis frequency between the cases and controls. Conclusions: The difference of micronuclei and apoptosis frequency between cases and controls was significant. The maximum number of cases came from highly arsenic affected areas and a higher percentage of cases showed elevated arsenic count, as compared to controls, which may indicate a possible link between arsenic toxicity and this disease. However, a larger sample size is required for a proper correlation. Int J Occup Med Environ Health 2017;30(2):271-279

show abstract

“…Interestingly, it is also present in ST products [42], although its role in oral carcinogenicity has not been assessed. Nickel is linked in the literature to nasal and lung cancers [43]; recently, it has also been implicated in oral cancer [44,45].…”

Section: Discussionmentioning

confidence: 99%

Differences in the Bacteriome of Smokeless Tobacco Products with Different Oral Carcinogenicity: Compositional and Predicted Functional Analysis

Al-Hebshi

Alharbi

Mahri

et al. 2017

Preprint

View full text Add to dashboard Cite

Smokeless tobacco (ST) products vary significantly in their oral carcinogenicity. Much is known about the differences in chemical, but not bacterial, constituents of these products. In this study, we explore the composition and function of the bacteriome in ST products from 4 countries using q-PCR and 16S rRNA-based next generation sequencing. The bacterial load (16S rRNA copies/gram) was lowest in Swedish snus (3.4E+6) and highest in Yemeni shammah (6.6E+11). A total of 491 species-level taxa, many of which are potentially novel, belonging to 178 genera and 11 phyla were identified. Species richness and diversity were highest for Swedish snus and lowest for Yemeni and nickel transport systems were enriched in the presumptively "high carcinogenicity" products.The bacteriome of ST products thus differed qualitatively, quantitatively and functionally. The relevance of these differences, particularly with respect to nickel and cadmium, to oral carcinogenesis warrants further investigation.

show abstract

Possible association between nickel and chromium and oral cancer: A case–control study in central Taiwan

Cited by 70 publications

References 33 publications

Oral Carcinoma, HPV Infection, Arsenic Exposure-their Correlation in West Bengal, India

Oral Carcinoma, HPV Infection, Arsenic Exposure-their Correlation in West Bengal, India

Study of arsenic exposure in oral/oropharyngeal carcinoma in West Bengal

Differences in the Bacteriome of Smokeless Tobacco Products with Different Oral Carcinogenicity: Compositional and Predicted Functional Analysis

Contact Info

Product

Resources

About