Possible association between non-invasive parameter of flow-mediated dilatation in brachial artery and whole coronary plaque vulnerability in patients with coronary artery disease

Sawada, Takahiro; Emoto, Takuo; Motoji, Yoshiki; Hashimoto, Megumi; Kageyama, Hiroko; Terashita, Daisuke; Mizoguchi, Takahiro; Mizuguchi, Toru; Iwasaki, Masanori; Taira, Kazuki; Okamoto, Hiroshi; Matsuo, Yosuke; Kim, Sushi-ku; Takarada, Akira; Yokoyama, Mitsuhiro

doi:10.1016/j.ijcard.2011.11.101

Cited by 25 publications

(32 citation statements)

References 23 publications

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“…Because the %FMD value is highly dependent on the baseline diameter of the vessel, we compared the baseline diameters and absolute changes in the brachial artery’s diameters for each group. We have also previously confirmed that there is excellent intra- and inter-observed agreement for the %FMD measurement [18, 19]. …”

Section: Methodssupporting

confidence: 74%

“…All participants rested for at least 15 min in a seated position in a quiet dark air-conditioned room (22–25 °C) before the FMD measurements, which was previously described [18, 19]. In brief, a longitudinal image of the right or left brachial artery was recorded at baseline using high-resolution ultrasonography and a 10-MHz linear array transducer probe (UNEX, Nagoya, Japan).…”

Section: Methodsmentioning

confidence: 99%

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Effects of 6-month eicosapentaenoic acid treatment on postprandial hyperglycemia, hyperlipidemia, insulin secretion ability, and concomitant endothelial dysfunction among newly-diagnosed impaired glucose metabolism patients with coronary artery disease. An open label, single blinded, prospective randomized controlled trial

Sawada

Tsubata

Hashimoto³

et al. 2016

Cardiovasc Diabetol

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BackgroundRecent experimental studies have revealed that n-3 fatty acids, such as eicosapentaenoic acid (EPA) regulate postprandial insulin secretion, and correct postprandial glucose and lipid abnormalities. However, the effects of 6-month EPA treatment on postprandial hyperglycemia and hyperlipidemia, insulin secretion, and concomitant endothelial dysfunction remain unknown in patients with impaired glucose metabolism (IGM) and coronary artery disease (CAD).Methods and resultsWe randomized 107 newly diagnosed IGM patients with CAD to receive either 1800 mg/day of EPA (EPA group, n = 53) or no EPA (n = 54). Cookie meal testing (carbohydrates: 75 g, fat: 28.5 g) and endothelial function testing using fasting-state flow-mediated dilatation (FMD) were performed before and after 6 months of treatment. The primary outcome of this study was changes in postprandial glycemic and triglyceridemic control and secondary outcomes were improvement of insulin secretion and endothelial dysfunction. After 6 months, the EPA group exhibited significant improvements in EPA/arachidonic acid, fasting triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C). The EPA group also exhibited significant decreases in the incremental TG peak, area under the curve (AUC) for postprandial TG, incremental glucose peak, AUC for postprandial glucose, and improvements in glycometabolism categorization. No significant changes were observed for hemoglobin A1c and fasting plasma glucose levels. The EPA group exhibited a significant increase in AUC-immune reactive insulin/AUC-plasma glucose ratio (which indicates postprandial insulin secretory ability) and significant improvements in FMD. Multiple regression analysis revealed that decreases in the TG/HDL-C ratio and incremental TG peak were independent predictors of FMD improvement in the EPA group.ConclusionsEPA corrected postprandial hypertriglyceridemia, hyperglycemia and insulin secretion ability. This amelioration of several metabolic abnormalities was accompanied by recovery of concomitant endothelial dysfunction in newly diagnosed IGM patients with CAD.Clinical Trial Registration UMIN Registry number: UMIN000011265 (https://www.upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&type=summary&recptno=R000013200&language=E)Electronic supplementary materialThe online version of this article (doi:10.1186/s12933-016-0437-y) contains supplementary material, which is available to authorized users.

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Section: Methodssupporting

confidence: 74%

Section: Methodsmentioning

confidence: 99%

Effects of 6-month eicosapentaenoic acid treatment on postprandial hyperglycemia, hyperlipidemia, insulin secretion ability, and concomitant endothelial dysfunction among newly-diagnosed impaired glucose metabolism patients with coronary artery disease. An open label, single blinded, prospective randomized controlled trial

Sawada

Tsubata

Hashimoto³

et al. 2016

Cardiovasc Diabetol

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“…Sawada et al [18] published results of a trial comparing ED and coronary atherosclerosis assessed by IVUS and VH. Unlike our study, they measured the ED by flow-mediated dilatation in a brachial artery.…”

Section: Discussionmentioning

confidence: 99%

“…Schoenenberger et al [19] did not find correlation between the lumen volume and RHI (they did not compare RHI and vessel area). Sawada et al [18] described the presence of more pronounced positive vessel remodelling in patients with ED. We can only speculate what the reasons are for these different findings.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore our finding of significant correlation between RHI≥ 2 and the vessel area cannot be compared. Sawada et al [18] found higher remodelling index values in patients with ED determined by brachial flow mediated dilatation. Considering that the remodelling index is an expression of comparison between the vessel location containing plaque and a plaque-free reference vessel location, no quantitative information about the absolute vessel size was available.…”

Section: Discussionmentioning

confidence: 99%

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Non-invasive endothelial function assessment using digital reactive hyperaemia correlates with three-dimensional intravascular ultrasound and virtual histology-derived plaque volume and plaque phenotype

et al. 2016

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Background and aim To study relationships between endothelial dysfunction (ED) and coronary atherosclerosis derived from intravascular ultrasound (IVUS) and virtual histology (VH). Methods Endothelial dysfunction was examined by EndoPAT system (Itamar Medical) in 56 patients who underwent IVUS and VH (Volcano corp.). Reactive hyperaemia index (RHI) < 2 was used for definition of ED. IVUS sequences were divided into 5 mm-long non-overlapping and adjacent vessel segments. Plaque phenotype was determined for each frame and 5 mm vessel segment was labeled according to highest frame score (from 0 for “no lesion” to 5 for “thin cap fibroatheroma; TCFA”). Results IVUS-VH data were collected from 41 patients suitable for three-dimensional analysis. Patients with ED exhibited larger plaque burden than those without ED (0.46 ± 0.08 vs. 0.39 ± 0.07, p = 0.014), smaller lumen area (8.59 ± 2.19 vs. 11.90 ± 3.50, p = 0.016), higher plaque risk score (2.82 ± 1.18 vs. 1.84 ± 0.90, p = 0.012), and higher number of TCFA frames (0.36 ± 0.22 vs. 0.22 ± 0.16, p = 0.038). Relative amounts of fibrous tissue correlated positively with RHI (p = 0.034, r = 0.33). The numbers of fibroatheromas and calcified plaques correlated with RHI inversely (r = 0.34, p = 0.031 and r = 0.32, p = 0.044, respectively). Conclusions Endothelial dysfunction correlates with severity and phenotype of coronary lesions and can contribute to non-invasive detection of individuals with higher risk of cardiovascular events.

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Imaging Biomarkers: Flow-Mediated Dilation as Predictor in Cardiovascular Disease

Bruno,

Badhwar,

Bianchini

et al. 2024

Early Vascular Aging (EVA)

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Possible association between non-invasive parameter of flow-mediated dilatation in brachial artery and whole coronary plaque vulnerability in patients with coronary artery disease

Cited by 25 publications

References 23 publications

Non-invasive endothelial function assessment using digital reactive hyperaemia correlates with three-dimensional intravascular ultrasound and virtual histology-derived plaque volume and plaque phenotype

Imaging Biomarkers: Flow-Mediated Dilation as Predictor in Cardiovascular Disease

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