Possible association of first and high birth order of pregnant women with the risk of isolated congenital abnormalities in Hungary – a population-based case-matched control study

Csermely, G; Susánszky, Éva; Czeizel, Andr̀ew E.; Veszprémi, Bela

doi:10.1016/j.ejogrb.2014.05.035

Cited by 8 publications

(5 citation statements)

References 13 publications

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“…and 7 malformations in 24 with live birth and pregnancy loss Group (7.14%). These observations of associations with first births were consistent with observations by McNeese ML et al and Csermely G et al 8,9 Further research on specific parameters viz biological, behavioral, and environmental factors and their association with first births need further exploration. In the present study in midtrimester abortions, the most common system with congenital malformations was CNS (23.46%) followed by multiple defects (9.18%) followed by the musculoskeletal system (5.10%) and other systems as mentioned above.…”

Section: -5supporting

confidence: 88%

The incidence of congenital malformations at birth and mid-trimester abortions and possible etiological factors in Pune camp, Maharashtra, India

Kumbhar¹,

Lele

2016

Int J Res Med Sci

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Section: -5supporting

confidence: 88%

The incidence of congenital malformations at birth and mid-trimester abortions and possible etiological factors in Pune camp, Maharashtra, India

Kumbhar¹,

Lele

2016

Int J Res Med Sci

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“…A recent meta‐analysis reported that clefting is associated with increasing birth order peaking at an odds ratio of 3.67 (95% CI, 3.36–3.99) in children birth order of 4 or more (Vieira and Orioli, ); however, as the authors pointed out by an editorial (Zeiger and Beaty, ), maternal age, smoking, nutrition, and other potential confounders could not be accounted for. Indeed, women with more children are generally older and increasing number of pregnancies especially with short intervals may be associated with nutritional deficiency (Luo et al, ; Csermely et al, ) or accumulation of DNA alterations due to lifestyle/environmental exposures (i.e., smoking). Furthermore, older maternal age is often correlated with older paternal age.…”

Section: Discussionmentioning

confidence: 99%

Parental risk factors for oral clefts among Central Africans, Southeast Asians, and Central Americans

Figueiredo

Magee

et al. 2015

Birth Defects Research

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BackgroundSeveral lifestyle and environmental exposures have been suspected as risk factors for oral clefts, although few have been convincingly demonstrated. Studies across global diverse populations could offer additional insight given varying types and levels of exposures.MethodsWe performed an international case–control study in the Democratic Republic of the Congo (133 cases, 301 controls), Vietnam (75 cases, 158 controls), the Philippines (102 cases, 152 controls), and Honduras (120 cases, 143 controls). Mothers were recruited from hospitals and their exposures were collected from interviewer‐administered questionnaires. We used logistic regression modeling to estimate odds ratios (OR) and 95% confidence intervals (CI).ResultsFamily history of clefts was strongly associated with increased risk (maternal: OR = 4.7; 95% CI, 3.0–7.2; paternal: OR = 10.5; 95% CI, 5.9–18.8; siblings: OR = 5.3; 95% CI, 1.4–19.9). Advanced maternal age (5 year OR = 1.2; 95% CI, 1.0–1.3), pregestational hypertension (OR = 2.6; 95% CI, 1.3–5.1), and gestational seizures (OR = 2.9; 95% CI, 1.1–7.4) were statistically significant risk factors. Lower maternal (secondary school OR = 1.6; 95% CI, 1.2–2.2; primary school OR = 2.4, 95% CI, 1.6–2.8) and paternal education (OR = 1.9; 95% CI, 1.4–2.5; and OR = 1.8; 95% CI, 1.1–2.9, respectively) and paternal tobacco smoking (OR = 1.5, 95% CI, 1.1–1.9) were associated with an increased risk. No other significant associations between maternal and paternal factors were found; some environmental factors including rural residency, indoor cooking with wood, chemicals and water source appeared to be associated with an increased risk in adjusted models.ConclusionOur study represents one of the first international studies investigating risk factors for clefts among multiethnic underserved populations. Our findings suggest a multifactorial etiology including both maternal and paternal factors. Birth Defects Research (Part A) 103:863–879, 2015. © 2015 The Authors Birth Defects Research Part A: Clinical and Molecular Teratology Published by Wiley Periodicals, Inc.

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“…58, 62,102 Maternal smoking has been reported to be an associated risk factor in CE 103 as well as high parity. 58,104 Obesity (BMI > 30) has also been identified as a potential risk factor for epispadias, as well as several other congenital malformations. 105 The pathogenic mechanisms of congenital malformations in obesity have been debated, in which connection, malnutrition, due to an inadequate diet and insufficient levels of essential micronutrients, may be involved.…”

Section: Environmental Risk Factorsmentioning

confidence: 99%

Maternal and fetal risk factors for bladder exstrophy: A nationwide Swedish case-control study

Engberg

Mantel

Fossum

et al. 2016

Journal of Pediatric Urology

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Possible association of first and high birth order of pregnant women with the risk of isolated congenital abnormalities in Hungary – a population-based case-matched control study

Cited by 8 publications

References 13 publications

The incidence of congenital malformations at birth and mid-trimester abortions and possible etiological factors in Pune camp, Maharashtra, India

The incidence of congenital malformations at birth and mid-trimester abortions and possible etiological factors in Pune camp, Maharashtra, India

Parental risk factors for oral clefts among Central Africans, Southeast Asians, and Central Americans

Maternal and fetal risk factors for bladder exstrophy: A nationwide Swedish case-control study

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