Possible association of ghrelin/obestatin balance with cardiometabolic risk in obese subjects with Helicobacter pylori

Ibrahim, Azza Saad; Eldeeb, Mona Kamal; Salama, Ola A.; Rashad, Mona M.; Okasha, Khaled Mohamed

doi:10.2478/enr-2018-0012

Cited by 7 publications

(4 citation statements)

References 41 publications

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“…Similar to our findings, other studies in humans have shown that plasma obestatin levels are significantly lower in obese subjects, as compared to controls, indicating a role for obestatin in long-term body weight regulation [20,17,21].…”

Section: Discussionsupporting

confidence: 92%

Plasma levels of obestatin and ghrelin and obestatin/ghrelin ratio in obese patients

Sfar¹,

Jemaa²,

Kallel³

et al. 2022

World J. Adv. Res. Rev.

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Background: Obestatin and ghrelin are two gastric hormones that have a potential role in dietary intake regulation. Obestatin/ghrelin ratio has been proposed as activity markers in obesity. The study aimed to evaluate ghrelin, obestatin and the ghrelin/obestatin ratio in obese compared to control subjects and to determine their relationship with anthropometric and metabolic parameters. Methods: Fasting obestatin and ghrelin levels were measured using enzyme-linked immunosorbent assay ELISA in 28 obese and 24 healthy subjects. The fasting ghrelin/obestatin ratio was calculated. Anthropometric and metabolic parameters were also assessed. Results: Obese patients had significantly lower obestatin and ghrelin blood levels compared with controls. The Ghrelin/Obestatin ratio was significantly lower in obese group 0.813±0.0417 ng/ml than in the control group 0.896±0.049 ng/ml, (p<0.001). In obese patients, obestatin and ghrelin were significantly and negatively correlated with BMI and positively correlated with HDL-C. Conclusion: Circulating preprandial ghrelin to obestatin ratio is decreased obese subjects. We suggest that low preprandial ghrelin to obestatin ratio may be involved in the etiology and pathophysiology of obesity.

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Section: Discussionsupporting

confidence: 92%

Plasma levels of obestatin and ghrelin and obestatin/ghrelin ratio in obese patients

Sfar¹,

Jemaa²,

Kallel³

et al. 2022

World J. Adv. Res. Rev.

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show abstract

“…Some studies have reported that serum leptin levels are signi cantly reduced in patients with H. pylori infection. [28,29] Low levels of leptin delay satiety while eating, causing excessive nutrient intake and obesity. [30] Second, insulin resistance is a signi cant risk factor for metabolic disorders.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Status, Obesity, and Helicobacter pylori infection: a cross-sectional study in US adults from NHANES 1999-2000

Chen,

Wang,

Yang

et al. 2023

Preprint

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Objective Recent studies on the association between Helicobacter pylori (H. pylori) infection and obesity have reported conflicting results. Therefore, the purpose of our study was to investigate the association of metabolic status and obesity with H.pylori infection. Methods A cross-sectional study of 1568 participants aged 20–85 years was conducted using the NHANES cycle 1999–2000. We used different anthropometric criteria to evaluate the association between general obesity, abdominal obesity, and H. pylori infection. Results After grouping individuals according to their body mass index and waist circumference, among subjects aged ≤ 50 years, the OR (95% CI) for subjects with a waist-height ratio of ≥ 0.5 in Model 1 was 1.87 (1.35–2.58) compared with the control group. This finding was still statistically significant in Models 2, 3, and 4, with ORs (95% CI) of 1.47 (0.99–2.18), 1.67 (1.16–2.41), and 2.23 (1.24–4.01), respectively. In Model 1, subjects older than 50 years old had an OR (95% CI) for metabolically healthy obesity of 0.09 (0.01–0.69), compared with the control group; after adjustment for major covariates, their ORs (95% CI) were 0.05 (0.00–2.87), 0.04 (0.01–0.35), and 0.04 (0.01–0.35) in Models 2, 3, and 4, respectively. Conclusions Abdominal obesity, as defined by the WHtR, was associated with H. pylori infection in subjects aged ≤ 50 years.

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“…In a recent study, the impact of H. pylori eradication on the metabolic response to bariatric surgery has been evaluated, showing a greater reduction in BMI at 3 months after surgery in patients treated for H. pylori ( 17 ). Previous studies have suggested that H. pylori infection may affect gastric hormones involved in appetite regulation, such as ghrelin and obestatin ( 46 ), that are mainly produced in the gastric fundus, so the relation between H. pylori infection, gastric hormones, and bariatric surgery is an issue that deserves further investigation. Indeed, the role of gastric hormones in bariatric surgery outcomes has been brought to light by a recent study that suggests a reprogramming of endocrine cell differentiation after bariatric surgery ( 47 ).…”

Section: Discussionmentioning

confidence: 99%

Influence of Factors Altering Gastric Microbiota on Bariatric Surgery Metabolic Outcomes

et al. 2021

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Possible association of ghrelin/obestatin balance with cardiometabolic risk in obese subjects with Helicobacter pylori

Cited by 7 publications

References 41 publications

Plasma levels of obestatin and ghrelin and obestatin/ghrelin ratio in obese patients

Plasma levels of obestatin and ghrelin and obestatin/ghrelin ratio in obese patients

Metabolic Status, Obesity, and Helicobacter pylori infection: a cross-sectional study in US adults from NHANES 1999-2000

Influence of Factors Altering Gastric Microbiota on Bariatric Surgery Metabolic Outcomes

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