Possible Basal Ganglia Pathology in Children With Complex Symptoms

Yaryura-Tobias, José A.; Rabinowitz, Dena; Neziroglu, Fugen

doi:10.4088/jcp.v64n1214

Cited by 11 publications

(2 citation statements)

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“…In the general population, motor or vocal tics, adventitial movements, complex-mannerisms, or bizarre motor behaviors may be seen in OCD [Yaryura-Tobias et al, 2003]. These symptoms, when present in pre-pubertal children with an abrupt symptom onset, should raise suspicion of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection or (PANDAS), [Snider and Swedo, 2004;Van Toorn et al, 2004].…”

Section: Associated Medical Factorsmentioning

confidence: 99%

Neurobehavioral disorders in children, adolescents, and young adults with Down syndrome

Capone

Goyal

Ares

et al. 2006

American J of Med Genetics Pt C

148

125

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The term dual-diagnosis refers to a person with mental retardation and a psychiatric disorder. Most children with Down syndrome (DS) do not have a psychiatric or neurobehavioral disorder. Current prevalence estimates of neurobehavioral and psychiatric co-morbidity in children with DS range from 18% to 38%. We have found it useful to distinguish conditions with a pre-pubertal onset from those presenting in the post-pubertal period, as these are biologically distinct periods each with a unique vulnerability to specific psychiatric disorders. Due to the increased recognition that psychiatric symptoms may co-occur with mental retardation, and are not inextricably linked to cognitive impairment, these conditions are considered treatable, in part, under a medical model. Improvement in physiologic regulation, emotional stability, and neurocognitive processing is one of the most elusive but fundamental goals of pharmacologic intervention in these disorders.

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Section: Associated Medical Factorsmentioning

confidence: 99%

Neurobehavioral disorders in children, adolescents, and young adults with Down syndrome

Capone

Goyal

Ares

et al. 2006

American J of Med Genetics Pt C

148

125

View full text Add to dashboard Cite

show abstract

“…Various environmental factors, including viral infection (Pineda et al 2007;Yaryura-Tobias et al 2003), maternal smoking during pregnancy (Agrawal et al 2010;Habek and Kovacevic 2010;Lindblad and Hjern 2010), prematurity of birth (Agrawal et al 2010), alcohol exposure (Brookes et al 2006;D'Onofrio et al 2007), lead exposure (Bellinger 2008;Nigg 2008), nutritional factors (Millichap 2008;Pelsser et al 2009a;McCann and Ames 2008;Richardson 2004;Tran et al 2002;McCann et al 2007), and endocrine disorders (Millichap 2008;Root 2006;Colborn 2004;Anderson et al 2000) may contribute as secondary causes of ADHD. The etiology is probably a combination of genetic and acquired factors in most cases (Millichap 2008;Cosgrove et al 2010).…”

Section: New Genetic Findings That Challenge Da-deficit Theorymentioning

confidence: 98%

Drug policy and treatment bias due to the dopamine-deficit theory of child attention-deficit hyperactivity disorder

Rastmanesh

2010

ADHD Atten Def Hyp Disord

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Abnormal dopamine (DA) transporter functioning has long been suspected to be involved in attention-deficit hyperactivity disorder (ADHD). My extensive search on theories concerning ADHD included: CENTRAL, MEDLINE, EMBASE, CINAHL, ERIC, PsycINFO, Complementary and Alternative Medicine-specific databases, Informit, JST, plus grey literature and trial registries from inception to May 2010. A new understanding of ADHD pathophysiology is required. DA-deficit theory of ADHD is insufficient to cover critical aspects of ADHD pathology and medication. The dominance of this theory discourages the human and financial investments needed to explore alternative theories and has caused an evident bias in health and drug policies. A combined theory of altered DA and serotonin (5HT), deficit DA, and weakened prefrontal cortex (PFC) circuits may serve as a good alternate to DA-theory alone. This combined theory may influence the future of drug polices, pharmaceutical investments, treatment options, and drug developments.

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Tic disorders and obsessive compulsive disorder: where is the link?

Roessner

Becker

Banaschewski

et al.

Neurodevelopmental Disorders

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Possible Basal Ganglia Pathology in Children With Complex Symptoms

Abstract: The specific symptoms identified and the biological factors found in many of the children seem to suggest basal ganglia involvement.

Cited by 11 publications

References 0 publications

Neurobehavioral disorders in children, adolescents, and young adults with Down syndrome

Neurobehavioral disorders in children, adolescents, and young adults with Down syndrome

Drug policy and treatment bias due to the dopamine-deficit theory of child attention-deficit hyperactivity disorder

Tic disorders and obsessive compulsive disorder: where is the link?

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