Possible biochemical mechanisms involved in beneficial and adverse effects of folates

Shaljyan, Alla; Левоновна, Шалджян Алла; Vardanyan, G. S.; Саркисовна, Варданян Гаяне; Saharyan, Anahit; Владимировна, Саарян Анаит; Aghajanov, M. I.; Иосифович, Агаджанов Михаил

doi:10.14341/omet201639-14

Obes. metabol.

2016

DOI: 10.14341/omet201639-14

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Possible biochemical mechanisms involved in beneficial and adverse effects of folates

Alla Shaljyan

Шалджян Алла Левоновна²,

G. S. Vardanyan

et al.

Abstract: О б з о р ы л и т е р а т у р ы Sola dosis facit venenum. Все есть яд, и все есть лекарство. Важна лишь доза.Парацельс.Ф олиевая кислота (витамин В 9 ) состоит из 2-амино-4-гидроксиптеридина (птерин), связанного с пара-аминобензойной кисло-той и остатком одной (в случае фолимоноглутамата) или более (в случае фолиполиглутамата) молекул глу-тамата. Различные коферментные формы витамина во-влечены в метаболизм одноуглеродных остатков. ИсточникиФолиевую кислоту из натуральных продуктов принято называть фолатом. Хо… Show more

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Effect of synthetic folic acid surplus on neurological symptoms in offspring

Kachanov,

Tikchonova,

Orlova

et al. 2023

Psychopharmacology & biological narcology

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Background. It has long been known about the need for folic acid for the vital activity of both macro-and microorganisms. It is necessary for the processes of methylation, nucleotide synthesis and also the formation of methionine and reducing the toxic effect of homocysteine. The addition of synthetic folic acid to the diet of pregnant women, as well as at the stage of pre-pregnancy preparation, significantly reduces the risks of fetal neural tube defects, heart defects, and possibly other organs and systems of the body. In addition, folic acid can help improve fertility potential. However, there is evidence of adverse effects of folic acid proficite on the health of older adults (hiding B12-deficient status) and the offspring of mothers taking high doses prescribed by medical specialists like a risks of infectious-inflammatory and allergic diseases of the upper respiratory tract in children, eczema, also disorders of psychomotor development and insulin resistance. In 1980, the direct excitatory effect of folic acid on synaptic transmission in the central nervous system was proved. This is due to the molecular structure, it contains L-glutamate. Therefore, the aim of the work was trying to prove the existing correlation data on probable neuropathologies, including a reduced threshold of seizures, a high risk of epilepsy in a model of offspring of Wistar rats with an increased dosage of folate throughout gestation and including at the stage of pre-gravidar preparation. Methods. We have determined the ability to the first convulsive act by introducing a 20% solution of caffeine at the rate of 100 mg/kg of weight intraperitoneally. Results. In the control group, the average clonus time was 1779.6 seconds, in the experimental group with a 1 mg/kg folic acid per diet dosage of 797.3 seconds, and in the second group with a 5 mg/kg folic acid per diet 439.7 seconds (p 0,01). Conclusion. The obtained results of the difference in the convulsive threshold may be due to changes in synaptic density as a result of an excess of synthetic folic acid during the formation of NT and subsequently during the differentiation of nervous tissue in the central nervous system (in particular, in the 3rd trimester with a massive appearance of glutamatergic receptors), which can affect the processes of neurogenesis and the formation of neural networks.

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Effect of synthetic folic acid surplus on neurological symptoms in offspring

Kachanov,

Tikchonova,

Orlova

et al. 2023

Psychopharmacology & biological narcology

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Correction of micronutrient deficiencies is one of the priority directions in the practical work of a pediatrician

Захарова¹,

Творогова²

2019

Medicinskij sovet

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Micronutrients (vitamins, minerals, micronutrients) are essential for the normal functioning of the body. The problem of vitamin deficiency leads to the risk of alimentary-dependent diseases. The reasons of inadequate provision with vitamins and minerals are given: unbalanced irrational nutrition, the quality of the products themselves, the nutritional value of which is significantly reduced with the use of modern production technologies. It is noted that the biological availability, i.e. the degree of absorption of vitamins from different products, varies widely from 5 to 80% of their total content in the product. In order to concretize the diverse physiological role of micronutrients as an important component of various enzyme systems and metabolic catalysts, the authors summarize the literature reflecting the importance of vitamins of group B, ascorbic acid, retinol, vitamin D and their functional correlations, as well as the need for a balanced and harmonious approach to their dosing. The problem of negative influence of deficiency of microelements on the structural and functional condition of various organs and systems, on morbidity, linear growth, development of various skills and psycho-emotional sphere of the child is covered. Attention is paid to the danger of micronutrient deficiency, which often remains unrecognized for a long time, because its clinical manifestations are not specific and can be observed in various diseases. However, the excess of individual micronutrients also disrupts the physiological and biochemical processes in the body. The vitamin requirements of healthy infants correspond to the amount of vitamins consumed daily with the mother’s milk: From 4-6 months of age, the provision of vitamins to the child is significantly affected by the introduction of complementary foods, for children from 1.5 to 3 years of age, the daily dose of vitamins and minerals in the VMC should not exceed 50% of the daily physiological needs, and for children over 3 years of age should not exceed 100% of the daily physiological needs for vitamins A, D and micronutrients (selenium, zinc, iodine, copper, iron), and 200% for water-soluble vitamins. An example of balanced and complete composition of vitamin complexes Multi-Tabs is given.

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Possible biochemical mechanisms involved in beneficial and adverse effects of folates

Cited by 2 publications

References 46 publications

Effect of synthetic folic acid surplus on neurological symptoms in offspring

Effect of synthetic folic acid surplus on neurological symptoms in offspring

Correction of micronutrient deficiencies is one of the priority directions in the practical work of a pediatrician

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