Possible Contribution of 2-Aminoethoxydiphenyl-borate-sensitive Ca2+ Mobilization to Adrenocorticotropin-induced Glucocorticoid Synthesis in Rat Adrenocortical Cells

Hayashi, Chiga; Iino, Kazumi; Osuga, Yutaka; Matsushita, Fumie; Yamashita, Miho; Yogo, Kosuke; Sasaki, Shigekazu; Kumada, Tatsuro; Nakamura, Hirotoshi

doi:10.1507/endocrj.k09e-138

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…For example, PREG binds the sigma‐1 (σ1) receptor, an endoplasmic reticulum‐associated chaperone highly expressed in the brain, including key dopaminergic regions 138 . This chaperon protein is localized in midbrain dopaminergic neurons and in the striatum, 139–141 where it modulates dopamine function and release 142 . Although the effects of σ1 receptor activation on dopamine system are conflicting, their ligands (including PREG) have been shown to attenuate dopamine signaling deregulation in response to psychostimulant drugs 142–144 .…”

Section: Pregnenolone Restores Pce Male Dopamine Function and Rescues...mentioning

confidence: 99%

Sex‐specific susceptibility to psychotic‐like states provoked by prenatal THC exposure: Reversal by pregnenolone

Frau

Melis

2023

J Neuroendocrinology

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Sociocultural attitudes towards cannabis legalization contribute to the common misconception that it is a relatively safe drug and its use during pregnancy poses no risk to the fetus. However, longitudinal studies demonstrate that maternal cannabis exposure results in adverse outcomes in the offspring, with a heightened risk for developing psychopathology. One of the most reported psychiatric outcomes is the proneness to psychotic‐like experiences during childhood. How exposure to cannabis during gestation increases psychosis susceptibility in children and adolescents remains elusive. Preclinical research has indicated that in utero exposure to the major psychoactive component of cannabis, delta‐9‐tetrahydrocannabinol (THC), deranges brain developmental trajectories towards vulnerable psychotic‐like endophenotypes later in life. Here, we present how prenatal THC exposure (PCE) deregulates mesolimbic dopamine development predisposing the offspring to schizophrenia‐relevant phenotypes, exclusively when exposed to environmental challenges, such as stress or THC. Detrimental effects of PCE are sex‐specific because female offspring do not display psychotic‐like outcomes upon exposure to these challenges. Moreover, we present how pregnenolone, a neurosteroid that showed beneficial properties on the effects elicited by cannabis intoxication, normalizes mesolimbic dopamine function and rescues psychotic‐like phenotypes. We, therefore, suggest this neurosteroid as a safe “disease‐modifying” aid to prevent the onset of psychoses in vulnerable individuals. Our findings corroborate clinical evidence and highlight the relevance of early diagnostic screening and preventative strategies for young individuals at risk for mental diseases, such as male PCE offspring.

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Section: Pregnenolone Restores Pce Male Dopamine Function and Rescues...mentioning

confidence: 99%

Sex‐specific susceptibility to psychotic‐like states provoked by prenatal THC exposure: Reversal by pregnenolone

Frau

Melis

2023

J Neuroendocrinology

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Selected tetrapeptides lead to a GLP-1 release from the human enteroendocrine cell line NCI-H716

Nevé

Daniel

2011

Regulatory Peptides

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Possible Contribution of 2-Aminoethoxydiphenyl-borate-sensitive Ca2+ Mobilization to Adrenocorticotropin-induced Glucocorticoid Synthesis in Rat Adrenocortical Cells

Abstract: Correspondence to: yutaka oKI, M.d., Ph.d., second division, department

Cited by 2 publications

References 25 publications

Sex‐specific susceptibility to psychotic‐like states provoked by prenatal THC exposure: Reversal by pregnenolone

Sex‐specific susceptibility to psychotic‐like states provoked by prenatal THC exposure: Reversal by pregnenolone

Selected tetrapeptides lead to a GLP-1 release from the human enteroendocrine cell line NCI-H716

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