Possible Dynamics of Polymer Chains by Means of a Ricatti s Procedure - an Exploitation for Drug Release at Large Time Intervals

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Colorectal cancer is a malignant disease with high morbidity and mortality. Ki-67 is a marker of cell proliferation associated with a low survival in colorectal cancer patients. Its expression is increased in patients with Dukes C or D colorectal cancer versus those in stage A or B. The purpose of the study is to evaluate the immunohistochemical expression of the Ki-67 marker in colorectal adenocarcinomas. The study was performed on a group of 28 patients diagnosed with rectal cancer. We made the histopathological and immunohistochemical evaluation of patients in the study group. The evaluation was performed on the sections stained with hematoxylin-eosin, and for mucinous forms, on sections stained with alcian blue. The topography of the Ki-67 reaction is strictly nuclear, evident in areas with intense proliferative activity. In cases with a strong positive response to Ki-67, the prognosis is worse, with invasion of the perirectal tissues and metastases. The lack of Ki-67 expression in nearby neoplastic tissues suggests that cancerous tissue proliferates in a pathway that it is not correlated with adjacent tissues. The Ki-67 could be useful in the prognosis of patients with colorectal cancer.

Section: Resultsmentioning

confidence: 99%

Anatomical and Immunohistochemical Evaluation of Colorectal Cancer

Hînganu¹,

Stan²,

Ciupilan³

et al. 2019

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“…Over time, iron deficiency anemia can occur Acupressure ulceration is a clinical reality, although it exaggerates due to the reserve of major digestive bleeding; after the ingestion of aspirin has gastric site and occurs in three situations: ill urinate, patients with ulcerogenic risk, genetic charge, old ulcero-duodenal [61][62][63][64][65][66][67][68] Aspirin produces gastric ulcer both to stimulate gastric acid secretion Davenport theory-updated by researches on reducing the electrical potential of the mucosa and by altering the quality of secreted gastric mucus. Gastric ulceration bleeds slightly due to the addition of aspirin effect on coagulation (on platelets) and prothrombin production.…”

Section: Resultsmentioning

confidence: 99%

General and Particular Structural Characteristics of Acetylsalicylic Acid - Aspirine Chemical properties

Topor¹,

Nechita²,

Debita³

et al. 2019

Anti-inflammatory-analgesic medication is known to have a wide spread, its indications going beyond the area of rheumatology, aimed at various fields, cardiology, nephrology, hematology,neurology, etc. Many years of aspirin has constituted the health expectation of millions of patients. Most nonsteroidal anti-inflammatory analgesics (ASNS) are acidic compounds derived mainly from carboxylic acids and enolic acids. The non-acidic compounds are numerically reduced and relatively unrelated. The main effects of non-steroidal anti-inflammatory analgesics arise following antipyretic action, analgesic action and anti-immflamatory in varying proportions to each structural group. Each drug has the specificity of single actions, the global way of explaining the clinical effects remains little known. Anti-inflammatory (anti-termic) in acute rheumatism or other inflammatory joint disorders, anti-platelet antiaggregant, aspirin prevents aggregation of blood platelets (which have a role in stopping bleeding).This is why it is used to prevent thrombosis (clotting of blood in the arteries or veins) with an impOliant role in preventing myocardial infarction. The study includes 126 patients who often used aspirin. Interaction of aspirin with other drugs mainly occurs in the plasma albumin, platelets, liver, kidney and gastrointestinal tract. Considered a common drug, often used by patients without the physician�s indication, some of them under maintenance medication (corticosteroid, anticoagulants, antiplatelet, antidiabetics, cytostatics), aspirin may cause important complications.

“…Medical treatment should ideally mimic the physiological intestinal status that is characterized by major digestion in the proximal intestine and the rapid decrease in lipolytic activity as intestinal chyme advances into the digestive tract [15][16][17][18][19][20]. Because enzyme replacement therapy is usually life-long, it is necessary to carefully study the potential side effects of these high-dose enzymes.…”

Section: Resultsmentioning

confidence: 99%

Enzymatic Treatment of Chronic Pancreatitis

Grigorovici¹,

Andronic²,

Hînganu³

et al. 2019

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The treatment of chronic pancreatitis consists of conservative and surgical treatment. The current development of interventional endoscopy techniques links the two above-mentioned treatments, offering less invasive solutions. In the treatment of chronic pancreatitis, a progressive approach is needed. Establishing any type of treatment is useless if the patient does not follow the recommendation to mainatin a proper diet. The study was conducted on a group of 61 patientshospitalized and operated for chronic forms of pancreatitis. Pancreatic insufficiency due to chronic pancreatitis is not a simple enzymatic deficiency, but an interactive complex of secretory, motor and endocrine functional disorders. Therefore, developing drug therapy will require not only the simple administration of enzymes in the intestine but also the restoration of the integrity of disruptive digestive functions.