Possible effects ofPhillyrea latifoliaon weight loss in rats fed a high-energy diet

Abstract

Context Phillyrea latifolia L. (Oleaceae), commonly found in the Mediterranean region in Turkey, is used as medicinal teas for weight loss and hyperglycaemia in folk medicine. Objective The study investigated the possible effects of P. latifolia leaves aqueous extract's on weight loss and biochemical-histological changes in the rats fed a high-energy diet (HED), also isolated and determined the main phenolic compounds. Materials and methods Twenty-four male Wistar albino rats were divided into four equal groups such as the HED group fed a HED, the PLE group given only the extract of P. latifolia leaves (220 mg/kg), the HED + PLE group administrated with the extract of leaves (220 mg/kg) after being fed with HED and a control group fed with standard pellet diet. Results PLE administration caused a remarkable decrement of body weight in the HED + PLE group (p < 0.05). PLE showed an improved effect on structural integrity and decreased leukocyte infiltration in liver and small intestinal tissues. The blood glucose (117.3 mmol/L), leptin (5.6 ng/mL), total cholesterol (61.8 mg/dL) and LDL (9.3 mmol/L) levels were significantly increased in the HED group. PLE administration in the HED group decreased these levels. The levels of HDL (26.8 mmol/L) in the HED + PLE group were higher than both control and HED groups. Chemical composition was investigated and luteolin 7-O-glucoside and chlorogenic acid were determined for the first time in Turkish sample from the EtOAc extract of leaves. Discussion and conclusion Phillyrea latifolia leaves may have beneficial effects on obesity related cellular problems and may become a good source of antidiabetic medication.

Body Weight Determination and Histological Examination of Livers in Normal Rats Administered with Tamsulosin

“…Weight is of great concern nowadays. Overweight is associated with obesity, which is a risk factor of many deadly diseases such as diabetes, cancer, hypertension, liver disease, cardiovascular disease and cancer (Yazici-Tutunis et al, 2016). Moreover, present study revealed lack of significant histological lesions in the livers of the tamsulosin and carvedilol-administered rats, indicating that the two (2) drugs are not hepatotoxic.…”

“…This was similar to the past studies which showed that alpha-1 adrenoceptors blockers have an advantageous effect on total cholesterol and triglycerides (Kabra, 2014). This observation might suggest that this drug have normal effect on leptic (a hormone that contribute hugely in weight regulation), dopamine, and serotonin (Yazici-Tutunis et al, 2016). Other researchers have proposed mechanisms via which alpha-1 adrenoceptorblockers affect cholesterol and triglyceride synthesis which include up-regulation of low-density lipoprotein receptors, leading to suppression of 3-hydroxy-3-methyl-glutarylcoenzyme A reductase (HMG) activity and consequently leading to a reduction in total cholesterol and low-density lipoprotein (Katzung, 2009).…”

Seasonal and Diurnal Variation in Leaf Phenolics of Three Medicinal Mediterranean Wild Species: What Is the Best Harvesting Moment to Obtain the Richest and the Most Antioxidant Extracts?

“…These compounds receive special attention nowadays for their biological activities, such as antimicrobial, anti-inflammatory, and anticancer [9,12]. Given the high flavonoid content of the studied species (Figure 2), they would represent raw materials for potential different products, including pharmaceutics and nutraceuticals that are based both on their traditional uses [23][24][25][26] and the scientific evidence [28,29,37,39].…”

“…Together, these compounds summed more than 90% of TPC (Figure 2A). Flavonoids with quercetin and luteolin aglycones were already described as important constituents of P. latifolia leaves [23,34,39,40]. Both aglycones have a catechol group in B ring of the flavonoid structure, a feature that confers them a high potential as free-radical scavengers [45].…”

“…In addition, non-boiled aqueous extracts of P. lentiscus have shown promising in vivo hepatoprotective activity by reducing the liver hepato-specific enzymes in the serum and can be applied for the treatment of hepatic jaundice [38]. This effect was also obtained with the boiled extracts of P. latifolia leaves, which resemble the traditional way of decoction preparations used as medicinal tea for weight loss and hyperglycaemia [39].…”