Possible effects of radiofrequency electromagnetic fields on in vivo C6 brain tumors in Wistar rats

Ouadah, Nihal S; Lecomte, Anthony; Robidel, Franck; Olsson, Ann; Deltour, Isabelle; Schüz, Joachim; Blazy, Kelly; Villegier, Anne‐Sophie

doi:10.1007/s11060-018-03012-y

Cited by 17 publications

(8 citation statements)

References 34 publications

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“…Building upon this, we performed in vitro experiments and the current findings using human bone as a barrier, implying that non-invasive plasma treatment can penetrate through large bone thicknesses to inhibit cancer cell growth. This is further supported by work demonstrating that EM waves (independent of CAP) can generate ROS/RNS [95,99], and these molecules can act as direct inhibitors of cancer and sensitize GBM to TMZ [100,101]. We also measured direct OES and the penetration of RONS through the bone in a test sample with and without the bone (data not shown).…”

Section: Discussionsupporting

confidence: 65%

In Vitro and In Vivo Enhancement of Temozolomide Effect in Human Glioblastoma by Non-Invasive Application of Cold Atmospheric Plasma

Soni

Adhikari

Simonyan

et al. 2021

Cancers

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Glioblastoma (GBM) is one of the most aggressive forms of adult brain cancers and is highly resistant to treatment, with a median survival of 12–18 months after diagnosis. The poor survival is due to its infiltrative pattern of invasion into the normal brain parenchyma, the diffuse nature of its growth, and its ability to quickly grow, spread, and relapse. Temozolomide is a well-known FDA-approved alkylating chemotherapy agent used for the treatment of high-grade malignant gliomas, and it has been shown to improve overall survival. However, in most cases, the tumor relapses. In recent years, CAP has been used as an emerging technology for cancer therapy. The purpose of this study was to implement a combination therapy of CAP and TMZ to enhance the effect of TMZ and apparently sensitize GBMs. In vitro evaluations in TMZ-sensitive and resistant GBM cell lines established a CAP chemotherapy enhancement and potential sensitization effect across various ranges of CAP jet application. This was further supported with in vivo findings demonstrating that a single CAP jet applied non-invasively through the skull potentially sensitizes GBM to subsequent treatment with TMZ. Gene functional enrichment analysis further demonstrated that co-treatment with CAP and TMZ resulted in a downregulation of cell cycle pathway genes. These observations indicate that CAP can be potentially useful in sensitizing GBM to chemotherapy and for the treatment of glioblastoma as a non-invasive translational therapy.

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Section: Discussionsupporting

confidence: 65%

In Vitro and In Vivo Enhancement of Temozolomide Effect in Human Glioblastoma by Non-Invasive Application of Cold Atmospheric Plasma

Soni

Adhikari

Simonyan

et al. 2021

Cancers

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“…The results of these tests indicate that EMF induces apoptosis through the inactivation of the ras → Erk survival signaling which is due to an enhanced degradation of ras and Raf-1 determined by a decreased expression of HSP90 and the consequent increase of proteasome dependent degradation. Ouadah et al [58] studied the effects of radiofrequency electromagnetic fields (900 MHz, 5 days a week, 45 min a day) on in vivo brain tumours in Wistar rats. The results suggested that the action of RF-EMF causes a reduction of immune cell invasion and glioblastoma cell apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Morphological and cytophysiological changes in selected lines of normal and cancer human cells under the influence of a radio-frequency electromagnetic field

Gorski

Nowak-Terpiłowska

Śledziński

et al. 2020

Ann Agric Environ Med.

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“…Besides analyses at multiple scales including cellular and molecular levels, rodent models can be used to investigate the effects of RF exposures during diseases, as illustrated by previous studies dedicated to the impact of GSM or WCDMA /3G UMTS EMF in the context of acute neuroinflammation, seizures, neurodegenerative diseases or glioma (Anane et al 2003;Arendash et al 2010;Carballo-Quintas et al 2011;Jeong et al 2015;Ouadah et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Exposure to 1800 MHz LTE electromagnetic fields under proinflammatory conditions decreases the response strength and increases the acoustic threshold of auditory cortical neurons

Souffi

Lameth

Gaucher

et al. 2022

Preprint

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Increased needs in mobile phone communications have raised successive generations (G) of wireless technologies, which could differentially affect biological systems. We have assessed how a single 2h head-only exposure to a 4G long term evolution (LTE)-1800 MHz electromagnetic field (EMF) impacts on the microglial space coverage and the electrophysiological neuronal activity in the primary auditory cortex (ACx) in rats submitted to an acute neuroinflammation induced by lipopolysaccharide. The mean specific absorption rate in the ACx was 0.5 W/kg. Multiunit recording revealed that LTE-EMF triggered reduction in the response strength to pure tones and to natural vocalizations, together with an increase in acoustic threshold in the low and medium frequencies. Iba1 immunohistochemistry showed no change in the area covered by microglia cell bodies and processes. In healthy rats, the same LTE-exposure induced no change in response strength and acoustic threshold. Our data indicate that an acute neuroinflammation sensitize neuronal responses to LTE-EMF, which leads to an altered processing of acoustic stimuli in the ACx.

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Possible effects of radiofrequency electromagnetic fields on in vivo C6 brain tumors in Wistar rats

Cited by 17 publications

References 34 publications

In Vitro and In Vivo Enhancement of Temozolomide Effect in Human Glioblastoma by Non-Invasive Application of Cold Atmospheric Plasma

In Vitro and In Vivo Enhancement of Temozolomide Effect in Human Glioblastoma by Non-Invasive Application of Cold Atmospheric Plasma

Morphological and cytophysiological changes in selected lines of normal and cancer human cells under the influence of a radio-frequency electromagnetic field

Exposure to 1800 MHz LTE electromagnetic fields under proinflammatory conditions decreases the response strength and increases the acoustic threshold of auditory cortical neurons

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